Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

(2011) J. Jakubikova et al.   BLOOD

The Reconstruction of Transcriptional Networks Reveals Critical Genes with Implications for Clinical Outcome of Multiple Myeloma

(2011) L. Agnelli et al.   CLINICAL CANCER RESEARCH

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma

(2011) J. Jakubikova et al.   HAEMATOLOGICA

Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors

(2010) A. Merchant et al.   BLOOD

Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

(2010) Stefan Peukert et al.   ChemMedChem

Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation

(2010) R R Singh et al.   LEUKEMIA

Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells

(2010) P Desch et al.   ONCOGENE

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

(2010) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance

(2009) S. Blotta et al.   BLOOD

Sonic Hedgehog Signaling Pathway Is Activated in ALK-Positive Anaplastic Large Cell Lymphoma

(2009) R. R. Singh et al.   CANCER RESEARCH

Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells

(2009) Masayoshi Kobune et al.   CANCER SCIENCE

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

(2009) Jie Gao et al.   Cell Stem Cell

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

(2009) Inga Hofmann et al.   Cell Stem Cell

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Cancer stem cells: controversies in multiple myeloma

(2009) Sarah K. Brennan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Bortezomib reverses a post-translational mechanism of tumorigenesis forpatched1haploinsufficiency in medulloblastoma

(2009) Eri Taniguchi et al.   PEDIATRIC BLOOD & CANCER

Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation

(2008) Christine Dierks et al.   CANCER CELL

Clonogenic Multiple Myeloma Progenitors, Stem Cell Properties, and Drug Resistance

(2008) W. Matsui et al.   CANCER RESEARCH

Multiple Myeloma Cancer Stem Cells

(2008) Carol Ann Huff et al.   JOURNAL OF CLINICAL ONCOLOGY

Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling

(2008) A. Varas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target

(2008) G. V. Hegde et al.   MOLECULAR CANCER RESEARCH

Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma

(2008) Ganapati V. Hegde et al.   MOLECULAR CANCER THERAPEUTICS