The hedgehog pathway in triple-negative breast cancer

Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508)

(2016) Chandra P. Belani et al.   CANCER

Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology

(2016) Paul S Weisman et al.   MODERN PATHOLOGY

Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer

(2015) Zhao-Heng Duan et al.   CANCER SCIENCE

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity

(2015) R. C. D'Angelo et al.   MOLECULAR CANCER THERAPEUTICS

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma

(2015) Ulrike Graab et al.   Oncotarget

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells

(2015) Maria Peiris-Pagès et al.   Oncotarget

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

(2015) Bingchen Han et al.   Cell Reports

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

(2015) Akwasi Agyeman et al.   Oncotarget

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

(2014) Z. Liu et al.   BLOOD

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

(2014) Bin Li et al.   CANCER RESEARCH

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation Trial of the Oral Investigational Hedgehog Signaling Pathway Inhibitor TAK-441 in Patients with Advanced Solid Tumors

(2014) J. Goldman et al.   CLINICAL CANCER RESEARCH

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

(2014) J. Rodon et al.   CLINICAL CANCER RESEARCH

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland

(2014) Nadia Okolowsky et al.   DEVELOPMENTAL BIOLOGY

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers

(2014) Jun Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Effects of themesenchymal dysplasiaGene Variant of Murine Patched-1 Protein on Canonical and Non-canonical Hedgehog Signaling Pathways

(2014) Malcolm C. Harvey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas

(2014) Dongsheng Yue et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sonic hedgehog–Gli1 signals promote epithelial–mesenchymal transition in ovarian cancer by mediating PI3K/AKT pathway

(2014) Zhang Ke et al.   MEDICAL ONCOLOGY

Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation

(2014) Ying Sun et al.   Molecular Cancer

Taxane-induced hedgehog signaling is linked to expansion of breast cancer stem-like populations after chemotherapy

(2014) Jennifer Sims-Mourtada et al.   MOLECULAR CARCINOGENESIS

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

(2014) Yujie Tang et al.   NATURE MEDICINE

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gli-1 is crucial for hypoxia-induced epithelial-mesenchymal transition and invasion of breast cancer

(2014) Jianjun Lei et al.   TUMOR BIOLOGY

Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial–mesenchymal transition in prostate cancer

(2014) Fukashi Yamamichi et al.   Scandinavian Journal of Urology

Biological subtypes of triple-negative breast cancer are associated with distinct morphological changes and clinical behaviour

(2013) Zeinab Elsawaf et al.   BREAST

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer

(2013) Chao Yang et al.   CANCER LETTERS

FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer

(2013) B. G. Hollier et al.   CANCER RESEARCH

Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes

(2013) H. Masuda et al.   CLINICAL CANCER RESEARCH

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition

(2013) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node–Negative Disease: Results From International Breast Cancer Study Group Trials VIII and IX

(2013) Otto Metzger-Filho et al.   JOURNAL OF CLINICAL ONCOLOGY

Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

(2013) Nataliya Razumilava et al.   JOURNAL OF HEPATOLOGY

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

(2013) Jianjun Lei et al.   Molecular Cancer

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

(2013) Mariella Gruber Filbin et al.   NATURE MEDICINE

Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer

(2013) E. S. Antonarakis et al.   ONCOLOGIST

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

(2013) Sonia Coni et al.   PLoS One

LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway

(2013) Zhigang Zhuang et al.   PLoS One

Emerging targeted therapies in triple-negative breast cancer

(2012) J. Crown et al.   ANNALS OF ONCOLOGY

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

(2012) I. S. Chan et al.   CANCER RESEARCH

Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway

(2012) B. Ramaswamy et al.   CANCER RESEARCH

A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer

(2012) J. Berlin et al.   CLINICAL CANCER RESEARCH

Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1

(2012) Hong Chang et al.   DEVELOPMENTAL BIOLOGY

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland

(2012) Elena García-Zaragoza et al.   DEVELOPMENTAL BIOLOGY

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin

(2012) Eri Makinodan et al.   EXPERIMENTAL DERMATOLOGY

Somatic mutations in the notch, NF-KB, PIK3CA, and hedgehog pathways in human breast cancers

(2012) Xiang Jiao et al.   GENES CHROMOSOMES & CANCER

Impact of Triple-Negative Breast Cancer Phenotype on Prognosis in Patients with Stage I Breast Cancer

(2012) Jeong Eun Kim et al.   Journal of Breast Cancer

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(2012) Rikke Leth-Larsen et al.   MOLECULAR MEDICINE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s)

(2012) K C Scribner et al.   ONCOGENE

FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling

(2012) J Wang et al.   ONCOGENE

Epithelial-Stromal Interactions in Human Breast Cancer: Effects on Adhesion, Plasma Membrane Fluidity and Migration Speed and Directness

(2012) Cristiana Angelucci et al.   PLoS One

ErbB receptor tyrosine kinase/NF- B signaling controls mammosphere formation in human breast cancer

(2012) K. Hinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary cilia and graded Sonic Hedgehog signaling

(2012) Noriaki Sasai et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

(2011) Z I Thomas et al.   BRITISH JOURNAL OF CANCER

Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity

(2011) S. Singh et al.   CANCER RESEARCH

Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer

(2011) S. A. O'Toole et al.   CANCER RESEARCH

Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

(2011) E. Heller et al.   CANCER RESEARCH

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines

(2011) Yeon-Jin Kwon et al.   CLINICAL & EXPERIMENTAL METASTASIS

Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened

(2011) Adriana P. Visbal et al.   DEVELOPMENTAL BIOLOGY

CD44+/CD24−/low cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome

(2011) Michael O. Idowu et al.   HUMAN PATHOLOGY

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells

(2011) X Cao et al.   ONCOGENE

Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61

(2011) L G Harris et al.   ONCOGENE

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

TGF-  Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling

(2010) R. W. Johnson et al.   CANCER RESEARCH

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

(2010) Pilar Chinchilla et al.   CELL CYCLE

Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis

(2010) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

(2010) B. Stecca et al.   Journal of Molecular Cell Biology

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

(2009) H Nalwoga et al.   BRITISH JOURNAL OF CANCER

Development of Mammary Tumors by Conditional Expression of GLI1

(2009) M. Fiaschi et al.   CANCER RESEARCH

Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

(2009) T. Tanei et al.   CLINICAL CANCER RESEARCH

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

Cloning of the HumanGLI2Promoter

(2009) Sylviane Dennler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hedgehog Pathway Transcription Factor GLI1 Promotes Malignant Behavior of Cancer Cells by Up-regulating Osteopontin

(2009) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer

(2009) Motoko Seto et al.   MOLECULAR CARCINOGENESIS

The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

(2009) Frédéric Mille et al.   NATURE CELL BIOLOGY

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Runx2 Transcriptional Activation of Indian Hedgehog and a Downstream Bone Metastatic Pathway in Breast Cancer Cells

(2008) J. Pratap et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription

(2008) Takahiro Hosoya et al.   CHEMBIOCHEM

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One