Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

(2015) Tapati Mazumdar et al.   Oncotarget

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer

(2015) Akwasi Agyeman et al.   Oncotarget

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma

(2015) Pritha Paul et al.   Oncotarget

Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome

(2014) M. Athar et al.   CANCER RESEARCH

ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

(2014) Erhong Meng et al.   PLoS One

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents

(2013) W Harrison et al.   ONCOGENE

Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress

(2012) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Topoisomerase 1 Inhibitors and Cancer Therapy

(2012) Julia Moukharskaya et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1 and inhibition of platinum–DNA adduct repair

(2012) K Kudo et al.   ONCOGENE

GLI1 Inhibition Promotes Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells

(2011) S. Joost et al.   CANCER RESEARCH

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

(2011) T. Mazumdar et al.   CANCER RESEARCH

Replication licensing promotes cyclin D1 expression and G1progression in untransformed human cells

(2011) Peijun Liu et al.   CELL CYCLE

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

(2011) Komaraiah Palle et al.   CELL CYCLE

The effect of the intra-S-phase checkpoint on origins of replication in human cells

(2011) Neerja Karnani et al.   GENES & DEVELOPMENT

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

(2011) Marie Regairaz et al.   JOURNAL OF CELL BIOLOGY

Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

(2010) T. Mazumdar et al.   CANCER RESEARCH

Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress

(2010) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

Expression of the glioma-associated oncogene homolog (GLI) 1in human breast cancer is associated with unfavourable overall survival

(2009) Anette ten Haaf et al.   BMC CANCER

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Enteric Neural Crest Differentiation in Ganglioneuromas Implicates Hedgehog Signaling in Peripheral Neuroblastic Tumor Pathogenesis

(2009) Timothy R. Gershon et al.   PLoS One

Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

(2009) Pierre-Olivier Frappart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

How ATR turns on: TopBP1 goes on ATRIP with ATR

(2008) A. E. Burrows et al.   GENES & DEVELOPMENT

Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability

(2008) Jennifer M. Leonard et al.   JOURNAL OF CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

(2008) D. Wilsker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA