Hedgehog signalling

Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling

(2015) Gisela D’Angelo et al.   DEVELOPMENTAL CELL

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function

(2015) Alexander M. Holtz et al.   JOURNAL OF CELL BIOLOGY

Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans

(2015) C. Ortmann et al.   JOURNAL OF CELL SCIENCE

Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling

(2015) Jinhu Wang et al.   NATURE

Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

(2015) Ljiljana Milenkovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoids are conserved inhibitors of the Hedgehog pathway

(2015) Helena Khaliullina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling networks organizing regenerative growth of the zebrafish fin

(2015) Daniel Wehner et al.   TRENDS IN GENETICS

Cytonemes as specialized signaling filopodia

(2014) T. B. Kornberg et al.   DEVELOPMENT

Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells

(2014) P. Jakobs et al.   JOURNAL OF CELL SCIENCE

Wing tips: The wing disc as a platform for studying Hedgehog signaling

(2014) Tom A. Hartl et al.   METHODS

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

(2014) Javier Lopez-Rios et al.   NATURE

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

(2014) Tamás Matusek et al.   NATURE

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens

(2013) Patricia T Yam et al.   CURRENT OPINION IN NEUROBIOLOGY

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

(2013) Ashish Kumar Maurya et al.   PLoS Genetics

Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors

(2013) Fan Ye et al.   eLife

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

(2013) Sigrid Nachtergaele et al.   eLife

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

(2011) Q. Shi et al.   DEVELOPMENT

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

(2011) Benjamin L. Allen et al.   DEVELOPMENTAL CELL

Hedgehog Activates Fused through Phosphorylation to Elicit a Full Spectrum of Pathway Responses

(2011) Qianhe Zhou et al.   DEVELOPMENTAL CELL

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

(2011) Kunyoo Shin et al.   NATURE

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling

(2011) Y. Su et al.   Science Signaling

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Hedgehog Signalling: Kif7 Is Not That Fishy After All

(2009) Philip W. Ingham et al.   CURRENT BIOLOGY

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

(2009) Y. Yin et al.   DEVELOPMENT

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

(2009) P. Huang et al.   DEVELOPMENT

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

(2008) Yong Pan et al.   DEVELOPMENTAL BIOLOGY

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE