Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

Small-Molecule Antagonists of the RIG-I Innate Immune Receptor

(2020) David C. Rawling et al.   ACS Chemical Biology

Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy

(2020) Ruifang Wang et al.   Autophagy

Foot-and-mouth disease virus 3A protein causes upregulating of autophagy-related protein LRRC25 to inhibit the G3BP1-mediated RLH signaling pathway

(2020) Wenping Yang et al.   JOURNAL OF VIROLOGY

The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

(2020) Harini Sooryanarain et al.   mBio

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

(2020) Akhee Sabiha Jahan et al.   Cell Reports

USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I

(2020) Xinyue Tao et al.   PLoS Pathogens

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination

(2020) Yuan-Qin Min et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response

(2020) Xuan Zhong et al.   PLoS Pathogens

RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication

(2020) Alison M. Kell et al.   PLoS Pathogens

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

(2020) Panpan Hou et al.   CELL RESEARCH

Autoimmunity gene IRGM suppresses cGAS ‐ STING and RIG ‐I‐ MAVS signaling to control interferon response

(2020) Kautilya Kumar Jena et al.   EMBO REPORTS

Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity

(2020) Zhengkui Zhang et al.   MOLECULAR CELL

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Spatiotemporal dynamics of innate immune signaling via RIG-I–like receptors

(2020) Katharina Esser-Nobis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

(2020) Jack Major et al.   SCIENCE

Type III interferons disrupt the lung epithelial barrier upon viral recognition

(2020) Achille Broggi et al.   SCIENCE

The role of host eIF2α in viral infection

(2020) Yuanzhi Liu et al.   Virology Journal

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

(2020) Linda J. Visser et al.   PLoS Pathogens

Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus

(2020) Pak-Hin Hinson Cheung et al.   PLoS Pathogens

Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses

(2020) Hiroyuki Oshiumi   Frontiers in Immunology

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Retinoic Acid Inducible Gene I and Protein Kinase R, but Not Stress Granules, Mediate the Proinflammatory Response to Yellow Fever Virus

(2020) Guillaume Beauclair et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation

(2019) GuanQun Liu et al.   JOURNAL OF VIROLOGY

Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease

(2019) Sup Kim et al.   Cells

NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages

(2019) Zhiyong Liu et al.   Science Advances

The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution

(2019) Jhih-Pu Lin et al.   PLoS Pathogens

RIG-I Selectively Discriminates against 5′-Monophosphate RNA

(2019) Xiaoming Ren et al.   Cell Reports

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

(2019) R. Alexander Wesselhoeft et al.   MOLECULAR CELL

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

(2019) Xiaohan Ning et al.   MOLECULAR CELL

The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-β response

(2019) Susana Soo-Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular sensing by phase separation: Using the process, not just the products

(2019) Haneul Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing

(2019) Yong Cheng et al.   EMBO REPORTS

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

(2019) Szu-Ting Chen et al.   Cell Host & Microbe

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production

(2019) Ruifang Wang et al.   Autophagy

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

(2019) Huifang Xian et al.   Autophagy

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

(2019) Cristhian Cadena et al.   CELL

The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination

(2019) Chang Liu et al.   JOURNAL OF IMMUNOLOGY

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection

(2019) Sowmya Pattabhi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Decoding type I and III interferon signalling during viral infection

(2019) Emily V. Mesev et al.   Nature Microbiology

Viral Regulation of RNA Granules in Infected Cells

(2019) Qiang Zhang et al.   VIROLOGICA SINICA

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

RIPLET and not TRIM 25 is required for endogenous RIG ‐I‐dependent anti‐viral responses

(2019) Thomas J Hayman et al.   IMMUNOLOGY AND CELL BIOLOGY

Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5

(2019) Yingjie Sun et al.   JOURNAL OF VIROLOGY

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

(2019) Konrad C. Bradley et al.   Cell Reports

A Human Long Non-coding RNA LncATV Promotes Virus Replication Through Restricting RIG-I–Mediated Innate Immunity

(2019) Jingjing Fan et al.   Frontiers in Immunology

LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

(2019) Raul Y. Sanchez David et al.   Science Signaling

Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I

(2019) Guanming Wang et al.   Cell Reports

MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

(2019) Nan Song et al.   Cell Reports

Identification of a new autoinhibitory domain of interferon-beta promoter stimulator-1 (IPS-1) for the tight regulation of oligomerization-driven signal activation

(2019) Kiyohiro Takahasi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

(2019) William Riedl et al.   Cell Host & Microbe

Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses

(2019) Xiaodong Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system

(2019) Adam Hage et al.   JOURNAL OF GENERAL VIROLOGY

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Strategies for Success. Viral Infections and Membraneless Organelles

(2019) Aracelly Gaete-Argel et al.   Frontiers in Cellular and Infection Microbiology

An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

(2019) Alessandro Pagliuso et al.   Cell Host & Microbe

LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection

(2019) Tomoko Takahashi et al.   NUCLEIC ACIDS RESEARCH

G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response

(2019) Wenping Yang et al.   Cell Death & Disease

Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation

(2019) Gianni Gori Savellini et al.   PLoS Pathogens

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response

(2018) Minghong Jiang et al.   CELL

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells

(2018) Annemarthe G van der Veen et al.   EMBO JOURNAL

The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling

(2018) Rocío Núñez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes

(2018) Zhenfeng Zhang et al.   JOURNAL OF HEPATOLOGY

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus

(2018) Junji Xing et al.   JOURNAL OF IMMUNOLOGY

Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production

(2018) Junjie Shao et al.   JOURNAL OF VIROLOGY

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

(2018) Maria T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses

(2018) Israel Cañadas et al.   NATURE MEDICINE

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

(2018) Peipei Zhou et al.   Nature Communications

Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit

(2018) Jeffrey D. Munzar et al.   Nature Communications

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

(2018) Maxime Chazal et al.   Cell Reports

DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity

(2018) Qingyuan Zhu et al.   PLoS Pathogens

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

(2018) Miguel Rodríguez Pulido et al.   PLoS Pathogens

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling

(2018) Jinzhu Ma et al.   Frontiers in Microbiology

Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response

(2018) Yusheng Wu et al.   EMBO JOURNAL

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

(2018) Christopher HC Tie et al.   EMBO REPORTS

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

(2018) Huan Lian et al.   IMMUNITY

FKBP8 inhibits virus-induced RLR-VISA signaling

(2018) Shan-Shan Xu et al.   JOURNAL OF MEDICAL VIROLOGY

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation

(2018) Antonio Gregorio Dias Junior et al.   TRENDS IN MICROBIOLOGY

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

(2018) Charlotte Lässig et al.   eLife

Mini viral RNAs act as innate immune agonists during influenza virus infection

(2018) Aartjan J. W. te Velthuis et al.   Nature Microbiology

FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

(2018) Tong Dai et al.   Cell Host & Microbe

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

(2018) Tianliang Li et al.   Cell Host & Microbe

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

(2018) Tianzi Liuyu et al.   CELL RESEARCH

USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses

(2018) Hongrui Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DDX58 and Classic Singleton-Merten Syndrome

(2018) Carlos R. Ferreira et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mycobacterium tuberculosis–induced IFN-β production requires cytosolic DNA and RNA sensing pathways

(2018) Yong Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense

(2018) Jacint G. Sanchez et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

(2018) Junsu Ban et al.   Viruses-Basel

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

(2018) Yang Zhao et al.   Nature Communications

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

(2017) Tan A. Nguyen et al.   IMMUNITY

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

(2017) Houbao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

(2017) Ian T. Lamborn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization

(2017) Pak-Yin Lui et al.   JOURNAL OF IMMUNOLOGY

DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70

(2017) Ken Takashima et al.   Journal of Innate Immunity

RIG-I-Like Receptors and Type I Interferonopathies

(2017) Hiroki Kato et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Multiple Functional Variants of IFIH1 , a Gene Involved in Triggering Innate Immune Responses, Protect against Vitiligo

(2017) Ying Jin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

(2017) Joschka Willemsen et al.   MOLECULAR CELL

Sensing Self and Foreign Circular RNAs by Intron Identity

(2017) Y. Grace Chen et al.   MOLECULAR CELL

ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65

(2017) Jun Meng et al.   Cell Death & Disease

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation

(2017) Zhen Ding et al.   Oncotarget

Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response

(2017) Takahisa Kouwaki et al.   Scientific Reports

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

(2017) Bing-Ru Yan et al.   PLoS Pathogens

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

(2017) Wei-Wei Luo et al.   PLoS Pathogens

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

(2017) Stephen Soonthornvacharin et al.   Nature Microbiology

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection

(2016) Akihiko Komuro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia

(2016) Jinbo Cheng et al.   CELL DEATH AND DIFFERENTIATION

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS

(2016) Lin-Gao Ju et al.   JOURNAL OF IMMUNOLOGY

Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS

(2016) Zhenjian He et al.   JOURNAL OF VIROLOGY

Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression

(2016) Zixiang Zhu et al.   JOURNAL OF VIROLOGY

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity

(2016) Ying Kai Chan et al.   NATURE IMMUNOLOGY

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

(2016) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

(2016) Wendie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform

(2016) Nhung T.H. Nguyen et al.   Scientific Reports

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules

(2016) Seong-Wook Oh et al.   PLoS Pathogens

Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories

(2016) Jovan Nikolic et al.   PLoS Pathogens

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

(2016) Raul Y Sanchez David et al.   eLife

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

(2016) Helene Minyi Liu et al.   EBioMedicine

Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome

(2015) Mi-Ae Jang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome

(2015) Frank Rutsch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses

(2015) Delphine Goubau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

(2015) Christine Schuberth-Wagner et al.   IMMUNITY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling

(2015) Jaehwan You et al.   JOURNAL OF VIROLOGY

Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection

(2015) Véronique Pène et al.   JOURNAL OF VIROLOGY

Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction

(2015) GuanQun Liu et al.   JOURNAL OF VIROLOGY

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

(2015) Cindy Chiang et al.   JOURNAL OF VIROLOGY

ATP-Dependent Effector-like Functions of RIG-I-like Receptors

(2015) Hui Yao et al.   MOLECULAR CELL

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

RIG-I in RNA virus recognition

(2015) Alison M. Kell et al.   VIROLOGY

Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells

(2015) Lianzhong Zhao et al.   Scientific Reports

RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response

(2015) Ken Takashima et al.   Cell Reports

DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

(2015) Hiroyuki Oshiumi et al.   Cell Reports

Inflammasome control of viral infection

(2015) Christopher Lupfer et al.   Current Opinion in Virology

Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs

(2015) Alex Heyam et al.   Wiley Interdisciplinary Reviews-RNA

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

(2015) Charlotte Lässig et al.   eLife

Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations

(2014) Hirotsugu Oda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5

(2014) Meredith E. Davis et al.   Cell Host & Microbe

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

(2014) Masahide Funabiki et al.   IMMUNITY

IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation

(2014) P. Zhang et al.   JOURNAL OF CELL SCIENCE

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza virus non-structural protein NS1: interferon antagonism and beyond

(2014) D. Marc   JOURNAL OF GENERAL VIROLOGY

Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+Efflux

(2014) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses

(2014) F. W. Santiago et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host Factor

(2014) K. Tawaratsumida et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

(2014) Sterling C Eckard et al.   NATURE IMMUNOLOGY

Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system

(2014) N. Sugimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

(2014) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25

(2014) E.-K. Pauli et al.   Science Signaling

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

RIG-I Detects mRNA of Intracellular Salmonella enterica Serovar Typhimurium during Bacterial Infection

(2014) M. Schmolke et al.   mBio

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection

(2014) Ryo Narita et al.   PLoS Pathogens

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

(2014) Ji-Seung Yoo et al.   PLoS Pathogens

In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells

(2014) Simon Runge et al.   PLoS Pathogens

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

(2014) Safia Deddouche et al.   eLife

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2014) Hui Xu et al.   eLife

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling

(2013) Michaela Weber et al.   Cell Host & Microbe

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

(2013) Jenish R Patel et al.   EMBO REPORTS

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I

(2013) G. Gori-Savellini et al.   JOURNAL OF VIROLOGY

MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon

(2013) M. A. Langereis et al.   JOURNAL OF VIROLOGY

Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses

(2013) C. S. Ng et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist

(2013) D. Niemeyer et al.   JOURNAL OF VIROLOGY

RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner

(2013) Alys Peisley et al.   MOLECULAR CELL

Liposome Delivery of MicroRNA-145 to Mesenchymal Stem Cells Leads to Immunological Off-target Effects Mediated by RIG-I

(2013) Tommy A Karlsen et al.   MOLECULAR THERAPY

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

(2013) Peter Liehl et al.   NATURE MEDICINE

RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells

(2013) Cristina Amparo Hagmann et al.   PLoS One

Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling

(2013) C. Motz et al.   SCIENCE

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

(2013) E. Kindler et al.   mBio

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

SKIV2L Mutations Cause Syndromic Diarrhea, or Trichohepatoenteric Syndrome

(2012) Alexandre Fabre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Autophagy in antiviral innate immunity

(2012) Clémence Richetta et al.   CELLULAR MICROBIOLOGY

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

(2012) Ian C Berke et al.   EMBO JOURNAL

RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids

(2012) Zeinab Abdullah et al.   EMBO JOURNAL

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses

(2012) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

The Multiple Functions of TRBP, at the Hub of Cell Responses to Viruses, Stress, and Cancer

(2012) S. M. Daniels et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

(2012) Ying Jin et al.   NATURE GENETICS

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Correction: Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

(2012) P. Ramanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments

(2012) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Native Influenza Virion Ribonucleoproteins

(2012) R. Arranz et al.   SCIENCE

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)

(2011) Xiang Zhou et al.   CELL RESEARCH

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-  and Serologic Autoimmunity in Lupus Patients

(2011) T. Robinson et al.   JOURNAL OF IMMUNOLOGY

DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

(2011) N. P. Maharaj et al.   JOURNAL OF VIROLOGY

The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3

(2011) A. Sen et al.   JOURNAL OF VIROLOGY

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

(2010) Hiroyuki Oshiumi et al.   Cell Host & Microbe

Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

(2010) Oliver Schulz et al.   Cell Host & Microbe

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential

(2010) Hiroyuki Oshiumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Unpaired 5′ ppp-Nucleotides, as Found in Arenavirus Double-stranded RNA Panhandles, Are Not Recognized by RIG-I

(2010) Jean-Baptiste Marq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

(2010) Estanislao Nistal-Villán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

(2010) Helle Kristiansen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

(2010) M. U. Gack et al.   JOURNAL OF VIROLOGY

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency

(2010) Ricardo C Ferreira et al.   NATURE GENETICS

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I

(2010) Penghua Wang et al.   NATURE IMMUNOLOGY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP

(2010) K. Malathi et al.   RNA

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

(2010) Kazuhide Onoguchi et al.   PLoS Pathogens

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

(2010) Leonid Gitlin et al.   PLoS Pathogens

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response

(2009) Ting Song et al.   FEBS LETTERS

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

(2009) Kiyohiro Takahasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA

(2009) Xiaojun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

(2009) Christian Enevold et al.   JOURNAL OF NEUROIMMUNOLOGY

Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I

(2009) Z. Ling et al.   JOURNAL OF VIROLOGY

Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction

(2009) L. Fan et al.   JOURNAL OF VIROLOGY

A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2

(2009) J.-P. Parisien et al.   JOURNAL OF VIROLOGY

Cleavage of IPS-1 in Cells Infected with Human Rhinovirus

(2009) J. Drahos et al.   JOURNAL OF VIROLOGY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

REUL Is a Novel E3 Ubiquitin Ligase and Stimulator of Retinoic-Acid-Inducible Gene-I

(2009) Dong Gao et al.   PLoS One

5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

(2009) A. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA

(2009) S. Myong et al.   SCIENCE

RIG-I is cleaved during picornavirus infection

(2009) Paola M. Barral et al.   VIROLOGY

A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

(2008) Gorben P. Pijlman et al.   Cell Host & Microbe

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

(2008) S. Liu et al.   HUMAN MOLECULAR GENETICS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins

(2008) K. S. Childs et al.   JOURNAL OF VIROLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

(2008) Matthias Habjan et al.   PLoS One

MDA-5 Recognition of a Murine Norovirus

(2008) Stephen A. McCartney et al.   PLoS Pathogens

Association of the IFIH1-GCA-KCNH7 chromosomal region with rheumatoid arthritis

(2007) A Martinez et al.   ANNALS OF THE RHEUMATIC DISEASES