Article
Fisheries
Lishuang Deng, Yang Feng, Ping OuYang, Defang Chen, Xiaoli Huang, Hongrui Guo, Huidan Deng, Jing Fang, Weimin Lai, Yi Geng
Summary: This study found that LMBV can induce autophagy in EPC cells, and enhancing autophagy can inhibit the replication and apoptosis of LMBV, while inhibiting autophagy produces the opposite effect. These findings have important implications for understanding the pathogenesis of LMBV and developing strategies to combat the disease.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenzhong Zheng, Kexin Wang, Yachen Wu, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen
Summary: C9orf72 interacts with eIF2 alpha to modulate translation initiation; C9orf72 knockout leads to global translation inhibition and primary ER stress; C9orf72 delays SG formation in stressed cells.
Article
Virology
Guang-Zhou Zhou, Jun Li, Yan-He Sun, Qin Zhang, Lu Zhang, Chao Pei
Summary: The study revealed that SCRV infection activates the mitochondrial apoptotic pathway, while inhibiting autophagy can delay apoptosis occurrence. Rapamycin reduces apoptotic cell proportion and affects the expression of autophagy-related factors and virus transcription levels during SCRV infection.
Article
Virology
Junchao Shi, Zi Li, Rongyi Xu, Jing Zhang, Qianyu Zhou, Rui Gao, Huijun Lu, Yungang Lan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He
Summary: This study demonstrates that PHEV infection induces ER stress and activates the unfolded protein response (UPR), which suppresses viral replication through the PERK/PKR-eIF2 alpha axis. Understanding coronavirus-induced ER stress and UPR activation may provide insights into the pathogenic mechanisms of coronaviruses and aid in developing new treatment strategies.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Tetsuya Yoshida, Masayuki Ishikawa, Kazuhiro Ishibashi
Summary: This study demonstrates that small RNA fragments derived from the NR region can inhibit the replication of TMV and affect the translation of mRNA.
Article
Virology
Barkha Ramnani, Shelby Powell, Adarsh G. Shetty, Praveen Manivannan, Brian R. Hibbard, Douglas W. Leaman, Krishnamurthy Malathi
Summary: Virus infection activates stress granule (SG) formation and interferes with the assembly of SG, indicating the important role of SG in antiviral defense. In this study, we found that fish cells respond to VHSV infection by forming SG, which requires PERK kinase and is essential for IFN production, antiviral signaling, and viral replication. Furthermore, the absence of G3BP1 leads to increased production of IFN, antiviral genes, and viral mRNA, but reduced viral protein synthesis and viral titers. Our findings highlight the critical role of ISR pathway activation and SG formation in regulating VHSV protein translation and replication.
Article
Biochemistry & Molecular Biology
Zuben P. Brown, Irina S. Abaeva, Swastik De, Christopher U. T. Hellen, Tatyana Pestova, Joachim Frank
Summary: This study presents cryo-EM structures of hepatitis C virus IRES initiation complexes, revealing the dynamic network of 40S/IRES contacts and the conformational changes during the transition from eIF2- to eIF5B-containing 48S complexes, providing important insights into the process of subunit joining.
Article
Microbiology
Han Zhong, Shuai Fan, Yongkun Du, Yuhang Zhang, Angke Zhang, Dawei Jiang, Shichong Han, Bo Wan, Gaiping Zhang
Summary: African swine fever (ASF) is a highly contagious and lethal disease of pigs caused by ASF virus (ASFV). In this study, the researchers investigated how ASFV MGF110-7L interacts with the eIF2 alpha signaling axis to control host translation and induce stress responses. They found that MGF110-7L triggers eIF2 alpha phosphorylation, translation suppression, and stress granule formation. Furthermore, MGF110-7L induces ER stress and the unfolded protein response, leading to translation reprogramming. These findings provide important insights into the translation regulation during ASFV infection and could guide the development of antiviral strategies.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Zhou Shen, Chen Chen, Yilin Yang, Zhenhua Xie, Qingying Ao, Lu Lv, Shoufeng Zhang, Huanchun Chen, Rongliang Hu, Hongjun Chen, Guiqing Peng
Summary: African swine fever virus (ASFV) is highly contagious and lethal in pigs, and understanding how ASFV proteins inhibit host translation through the transmembrane domain of pE66L sheds light on the mechanism of host translation shut-off induced by ASFV. This study provides important insights into the interaction between ASFV and its host cells, suggesting that ASFV pE66L plays a key role in modulating host gene expression.
JOURNAL OF VIROLOGY
(2021)
Review
Microbiology
Sahibzada Waheed Abdullah, Jin'en Wu, Xuefei Wang, Huichen Guo, Shiqi Sun
Summary: This review discusses the various types of IRESs found in Picornaviridae and the past and present discoveries regarding ITAFs and their mechanism of action. It also summarizes the importance of herbal extracts, drugs, and chemicals in controlling picornavirus translation and replication. The movement of ITAFs from the nucleus to viral replication factories is also discussed.
Article
Plant Sciences
Bowen Sun, Lin Lin, Tian Yao, Jingchun Yao, Guimin Zhang, Yunlun Li, Chao Li
Summary: This study found that Jingfang Granules (JFG) significantly alleviated pathological damage in the cardiac tissues of coxsackievirus B3-induced viral myocarditis mice and attenuated the expression of inflammatory genes. JFG may exert its therapeutic effects by enhancing autophagy to suppress cell apoptosis, thereby reducing cell damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Oncology
Margarita Kamynina, Salome Tskhovrebova, Jawad Fares, Peter Timashev, Anastasia Laevskaya, Ilya Ulasov
Summary: Glioblastoma (GBM) is the most common and aggressive brain tumor with limited therapeutic options. Gene therapies using self-replicating oncolytic viruses may advance GBM treatment. Autophagy in glioblastoma plays a dual role in cell death and survival.
Article
Virology
Bin Liu, Yahui Zhang, Hao Ren, Qiufeng Yao, Jianbo Ba, Jie Luan, Ping Zhao, Zhaoling Qin, Zhongtian Qi
Summary: This study reveals the role of the mTOR signaling pathway in Zika virus infection, showing that autophagy promotes viral production while viral protein expression is regulated by the mTOR signaling pathway. This provides theoretical support for developing potential anti-Zika virus drugs based on mTOR signaling molecules and deeper insights into the mechanism between Zika virus and host cells.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Plant Sciences
Ivana Jovanovic, Nicole Frantova, Jan Zouhar
Summary: The plant endomembrane system plays a crucial role in plant growth and development, as well as in responses to abiotic and biotic stresses. Plant viruses remodel this system to create replication compartments and evade host defenses. Recent research has revealed that plant antiviral immunity involves receptor-like kinases and selective autophagy, highlighting the complex interplay between viral components and the plant endomembrane-associated pathways.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Immunology
Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Kai Zhang, Zhiting Guo, Songwei Han, Lei Wang, Zhengying Qiu, Guibo Wang, Jianxi Li
Summary: Avian infectious bronchitis virus (IBV) is a cause of severe production losses in the poultry industry worldwide. This study found that phillygenin, a compound found in Forsythiae Fructus, can inhibit IBV replication by interfering with multiple stages of the virus life cycle. It activates the antiviral response in cells and shows potential as a novel drug for IBV prevention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Zihan Lin, Lijuan Liao, Shengchao Zhao, Wei Gu, Guanzhen Wang, Ziyi Shen, Yuanhui Wang, Kun Chen, Wei Liu, Yi Cai, Chunpeng Wan, Tingdong Yan
Summary: The study found that corylin is a substance that inhibits the progression of non-small cell lung cancer cells, and it inhibits the NF-kappa B signaling pathway by blocking p65 nuclear translocation. The study provides a novel strategy for improving the prognosis and treatment of non-small cell lung cancer patients.
Review
Food Science & Technology
Zaixiang Lou, Xiaodan Zheng, Dery Bede, Wenna Dai, Chunpeng Wan, Hongxin Wang, Xiaohua Chen
Summary: Biofilm is a stable microbial community with probiotic strains that have beneficial effects. This article introduces the formation process and regulatory mechanisms of biofilm, and reviews strategies to promote biofilm growth. The extraction and purification process of natural products in exogenous substances are summarized. Studies have found various ways to promote biofilm formation, such as interfering with quorum sensing pathways and adhesion mechanisms. Probiotics and their secondary metabolites, as well as certain ingredients like hormones and natural extracts, play critical roles in promoting biofilm formation.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Food Science & Technology
Yupei Zhang, Duo Lin, Ruyu Yan, Yunhe Xu, Mengying Xing, Shuyuan Liao, Chunpeng Wan, Chuying Chen, Liqin Zhu, Wenbin Kai, Jinyin Chen, Zengyu Gan
Summary: This study investigated the effect of fucoidan treatment on cucumber under cold stress. The results showed that fucoidan treatment alleviated chilling injury, delayed weight loss, and lowered electrolyte leakage and respiration rate in cold-stored cucumbers. Fucoidan also maintained the integrity of cell membrane and reduced membrane lipid peroxidation.
Article
Virology
Chuanjie Zhou, Yunchao Liu, Qiang Wei, Yumei Chen, Suzhen Yang, Anchun Cheng, Gaiping Zhang
Summary: PEDV infection causes severe piglet mortality and threatens the global pig industry. However, the complex invasion mechanism of PEDV makes its prevention and control difficult.
JOURNAL OF VIROLOGY
(2023)
Article
Plant Sciences
Yi Cai, Shisheng Jiang, Chaoming Huang, Ao Shen, Xuan Zhang, Wanling Yang, Yichuan Xiao, Shuhan Gao, Rong Du, Guodong Zheng, Tingdong Yan, Chunpeng (Craig) Wan
Summary: In this study, baicalin was found to suppress cardiac hypertrophy through regulating the SIRT3/LKB1/AMPK signaling pathway. Additionally, baicalin upregulated SIRT3 protein expression by inhibiting proteasome and activating PSMB5. These results provide the first evidence that baicalin inhibits cardiac hypertrophy by targeting the SIRT3-dependent signaling pathway, suggesting its potential for the treatment of cardiac hypertrophy and heart failure.
Article
Agriculture, Dairy & Animal Science
Jianping Wang, Tao Zhang, Chunpeng Wan, Zhangfeng Lai, Jun Li, Luojun Chen, Mingxi Li
Summary: Pu-erh tea theabrownins (TBs) improve egg quality and antioxidant properties by modulating amino acid and fatty acid compositions, and activating the Nrf2-ARE signaling pathway.
Article
Food Science & Technology
Chunpeng (Craig) Wan, Xiaomeng Hu, Mingxi Li, Kannan R. R. Rengasamy, Yi Cai, Zhonghua Liu
Summary: Green tea and its active extracts are commonly used in dietary supplements, but little is known about their interactions with protein targets. In this study, the researchers used bioinformatics to analyze the interactions between diabetes-related targets and green tea bioactive compounds, leading to the identification of core targets. In vitro experiments demonstrated that the major polyphenolic component of green tea, EGCG, inhibited high glucose-induced cardiomyocyte hypertrophy, inflammation, oxidative stress response, and cellular senescence. The protective effects of EGCG were found to be mediated through PPARG-dependent pathways. This study provides comprehensive insights into the role of EGCG in high glucose-induced myocardial cell injury and aging.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Editorial Material
Microbiology
Hui Zhang, Mujeeb Ur Rehman, Yung-Fu Chang, Tang Zhaoxin
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Ze-Jun Pei, Chengcheng Li, Wenna Dai, Zaixiang Lou, Xin Sun, Hongxin Wang, Azmat Ali Khan, Chunpeng Wan
Summary: This study investigated the anti-biofilm activity and mechanism of gallic acid (GA), kaempferol-7-O-glucoside (K7G), and apigenin-7-O-glucoside (A7G) against Staphylococcus aureus and Escherichia coli. A7G showed the strongest anti-biofilm and antibacterial activities. The inhibition of A7G on biofilm was achieved through inhibiting exopolysaccharides (EPS), quorum sensing (QS), and cell surface hydrophobicity (CSH). A7G could be a promising novel antibacterial and anti-biofilm agent for control of biofilm in the food industry.
INFECTION AND DRUG RESISTANCE
(2023)
Editorial Material
Veterinary Sciences
Mujeeb Ur Rehman
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Zhenqin Zheng, Long Zhang, Qi Luo, Chunxu Mao, Yejun He, Steven Gao
Summary: This research proposes a wideband 3-D-printed transmit-reflect-array (TRA) antenna that can generate independent transmission and reflection beams over a wide bandwidth. The TRA element, composed of a dielectric post and three copper wires, can be fabricated using low-cost 3-D printing. The measured results show high gain and wide bandwidth for both the transmitarray (TA) and reflectarray (RA) functions of the 3-D-printed TRA antenna, making it appealing for various wireless applications.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Virology
Yuhong Pan, Wenjun Cai, Anchun Cheng, Mingshu Wang, Juan Huang, Shun Chen, Qiao Yang, Ying Wu, Di Sun, Sai Mao, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Qun Gao, Xumin Ou, Bin Tian, Zhongqiong Yin, Renyong Jia
Summary: In this study, the mechanism of apoptosis induced by Duck Tembusu virus (DTMUV) infection was investigated. The activation of endoplasmic reticulum stress (ERS) was found to be involved in DTMUV-induced apoptosis. The study also revealed that the nonstructural protein 3 (NS3) of DTMUV is the main inducer of apoptosis. The findings provide a theoretical basis for understanding the pathogenic mechanism of DTMUV infection and identifying potential antiviral targets.
JOURNAL OF VIROLOGY
(2023)
Review
Plant Sciences
Qinan Yin, Xiaoqin Zhang, Suqing Liao, Xiaobo Huang, Chunpeng Craig Wan, Yi Wang
Summary: This study aims to summarize the recent research progress on coagulation mechanisms, new anticoagulant targets, and traditional Chinese medicine. Through literature review, it is found that active components extracted from Chinese medicinal herbs, including Salvia miltiorrhiza, Chuanxiong rhizoma, safflower, and Panax notoginseng, have significant anticoagulant effects and can be potential anticoagulant drugs, but the risk of bleeding is unclear. TF/FVIIa, FVIII, FIX, FXI, FXII, and FXIII have all been evaluated as targets in animal studies or clinical trials. Among them, FXI inhibitors have shown stronger advantages. In conclusion, this review provides a comprehensive resource for potential anticoagulants, and FXI inhibitors can be considered as potential anticoagulant candidates. The anticoagulant effect of traditional Chinese medicine should not be ignored, and more research and new drugs are expected.
Article
Microbiology
Chunmei Li, Mingshu Wang, Anchun Cheng, Ying Wu, Bin Tian, Qiao Yang, Qun Gao, Di Sun, Shaqiu Zhang, Xumin Ou, Yu He, Juan Huang, Xinxin Zhao, Shun Chen, Dekang Zhu, Mafeng Liu, Renyong Jia
Summary: Duck plague is a highly morbid and deadly disease that causes significant losses in the duck breeding industry. The causative agent is Duck plague virus (DPV) and its UL10 protein (pUL10) plays complex roles in viral fusion, assembly, cell-to-cell spread, and immune evasion, which are closely related to its protein characteristics and partners.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Liping Wu, Mingshu Wang, Anchun Cheng, Bin Tian, Juan Huang, Ying Wu, Qiao Yang, Xumin Ou, Di Sun, Shaqiu Zhang, Xinxin Zhao, Qun Gao, Yu He, Dekang Zhu, Shun Chen, Mafeng Liu, Renyong Jia
Summary: Duck plague virus (DPV) is a significant infectious and fatal disease for geese, ducks, and other wild waterfowl. Our study found that the VP22 protein in DPV plays a crucial role in viral growth, spread, and RNA accumulation, providing a foundation for further research on the function of VP22 in DPV or other herpesviruses.
VETERINARY RESEARCH
(2023)
