To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system

TRIM proteins

(2019) Milica Vunjak et al.   CURRENT BIOLOGY

NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages

(2019) Zhiyong Liu et al.   Science Advances

Inhibition of Influenza A Virus Replication by TRIM14 via Its Multifaceted Protein–Protein Interaction With NP

(2019) Xiangwei Wu et al.   Frontiers in Microbiology

TRIM2, a novel member of the antiviral family, limits New World arenavirus entry

(2019) Nicolas Sarute et al.   PLOS BIOLOGY

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

(2019) Sathish Kumar et al.   Cell Reports

RIG-I Selectively Discriminates against 5′-Monophosphate RNA

(2019) Xiaoming Ren et al.   Cell Reports

Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

(2019) Hashim Ali et al.   Nature Communications

TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response

(2019) Feng Zheng et al.   INFLAMMATION

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

(2019) Szu-Ting Chen et al.   Cell Host & Microbe

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

(2019) Cristhian Cadena et al.   CELL

E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages

(2019) Mingfeng Lu et al.   MOLECULAR IMMUNOLOGY

The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response

(2019) Hongyu Lin et al.   NATURE IMMUNOLOGY

Interferon-inducible TRIM22 contributes to maintenance of HIV-1 proviral latency in T cell lines

(2019) Filippo Turrini et al.   VIRUS RESEARCH

E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis

(2019) Guangwei Zeng et al.   Aging-US

RIPLET and not TRIM 25 is required for endogenous RIG ‐I‐dependent anti‐viral responses

(2019) Thomas J Hayman et al.   IMMUNOLOGY AND CELL BIOLOGY

Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy

(2019) Xing Liu et al.   JOURNAL OF VIROLOGY

The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus

(2019) Kaikai Han et al.   MICROBIAL PATHOGENESIS

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Restriction of HIV-1 and other retroviruses by TRIM5

(2019) Barbie K. Ganser-Pornillos et al.   NATURE REVIEWS MICROBIOLOGY

Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination

(2019) Kuan Zhao et al.   VETERINARY MICROBIOLOGY

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation

(2019) Abhilash I. Chiramel et al.   Cell Reports

The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function

(2019) Darong Yang et al.   PLoS Neglected Tropical Diseases

TRIM14 expression is regulated by IRF‐1 and IRF‐2

(2019) Jingang Cui et al.   FEBS Open Bio

An E3 ubiquitin ligase TRIM9 is involved in WSSV infection via interaction with β-TrCP

(2019) Mingzhe Sun et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation

(2018) Kabsun Kim et al.   BONE

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

The interferon-stimulated gene TRIM22 : A double-edged sword in HIV-1 infection

(2018) Elisa Vicenzi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

USP7–TRIM27 axis negatively modulates antiviral type I IFN signaling

(2018) Juan Cai et al.   FASEB JOURNAL

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus

(2018) Junji Xing et al.   JOURNAL OF IMMUNOLOGY

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection

(2018) Girish Patil et al.   JOURNAL OF VIROLOGY

TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

(2018) Binbin Xue et al.   JOURNAL OF VIROLOGY

Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling

(2018) Maria T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

Genomics: CRISPR–Cas goes RNA

(2018) Stéphane Larochelle   NATURE METHODS

UBXN3B positively regulates STING-mediated antiviral immune responses

(2018) Long Yang et al.   Nature Communications

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication

(2018) Julianna Han et al.   Cell Reports

TRIM proteins: New players in virus-induced autophagy

(2018) Konstantin M. J. Sparrer et al.   PLoS Pathogens

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses

(2018) Yuexiu Zhang et al.   Frontiers in Immunology

Regulation of RIG-I Activation by K63-Linked Polyubiquitination

(2018) Masaaki Okamoto et al.   Frontiers in Immunology

Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy

(2018) Deyan Chen et al.   Frontiers in Immunology

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

(2018) Isabel Pagani et al.   mSphere

TRIM29 negatively controls antiviral immune response through targeting STING for degradation

(2018) Qijie Li et al.   Cell Discovery

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

(2018) Huan Lian et al.   IMMUNITY

Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3

(2018) Kezhen Wang et al.   PLoS Pathogens

Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx

(2018) Guangyun Tan et al.   Frontiers in Immunology

Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells

(2018) Tim Krischuns et al.   Frontiers in Immunology

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

(2018) Adam J. Fletcher et al.   Cell Host & Microbe

Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight

(2018) Wesley I. Sundquist et al.   Cell Host & Microbe

Fish-specific finTRIM FTR36 triggers IFN pathway and mediates inhibition of viral replication

(2018) Bo Chen et al.   FISH & SHELLFISH IMMUNOLOGY

Ubiquitination Is Essential for Avibirnavirus Replication by Supporting VP1 Polymerase Activity

(2018) Huansheng Wu et al.   JOURNAL OF VIROLOGY

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening

(2018) Robert C. Orchard et al.   JOURNAL OF VIROLOGY

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

(2018) Junsu Ban et al.   Viruses-Basel

Rhabdoviruses, Antiviral Defense, and SUMO Pathway

(2018) Faten El Asmi et al.   Viruses-Basel

TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production

(2018) Hui Liu et al.   Frontiers in Immunology

Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity

(2018) Florian Full et al.   Nature Microbiology

Fish antiviral tripartite motif (TRIM) proteins

(2018) Christelle Langevin et al.   FISH & SHELLFISH IMMUNOLOGY

Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus

(2017) Yepin Yu et al.   FISH & SHELLFISH IMMUNOLOGY

Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR ofTRIM22

(2017) Keo-Heun Lim et al.   GUT

PML is a ROS sensor activating p53 upon oxidative stress

(2017) Michiko Niwa-Kawakita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles

(2017) Wen-Chi Su et al.   JOURNAL OF VIROLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication

(2017) Preeti Bharaj et al.   JOURNAL OF VIROLOGY

TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway

(2017) Wenchun Fan et al.   MOLECULAR IMMUNOLOGY

Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain

(2017) Amélie Wallenhammar et al.   PLoS One

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction

(2017) Rajan Lamichhane et al.   VIROLOGY

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

(2017) Yu-Chen Lin et al.   mBio

TRIM29 promotes DNA virus infections by inhibiting innate immune response

(2017) Junji Xing et al.   Nature Communications

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

(2017) Yuheng Shi et al.   Nature Communications

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

(2017) Marcin D. Roganowicz et al.   PLoS Pathogens

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

TRIM5α Promotes Ubiquitination of Rta from Epstein–Barr Virus to Attenuate Lytic Progression

(2017) Hsiang-Hung Huang et al.   Frontiers in Microbiology

Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1

(2017) Greta Forlani et al.   Frontiers in Immunology

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection

(2017) Christelle Langevin et al.   Frontiers in Immunology

TRIM23 mediates virus-induced autophagy via activation of TBK1

(2017) Konstantin M. J. Sparrer et al.   Nature Microbiology

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1

(2016) Yunfei Qin et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper

(2016) Ying Yang et al.   FISH & SHELLFISH IMMUNOLOGY

Fish TRIM39 regulates cell cycle progression and exerts its antiviral function against iridovirus and nodavirus

(2016) Wei Wang et al.   FISH & SHELLFISH IMMUNOLOGY

The first molluscan TRIM9 is involved in the negative regulation of NF-κB activity in the Hong Kong oyster, Crassostrea hongkongensis

(2016) Ying Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

Crystal structure of the Trim5α Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface

(2016) Jeremy Russell Keown et al.   JOURNAL OF STRUCTURAL BIOLOGY

The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis

(2016) Baoming Liu et al.   JOURNAL OF VIROLOGY

Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21

(2016) Adam J. Fletcher et al.   JOURNAL OF VIROLOGY

Ubiquitination Upregulates Influenza Virus Polymerase Function

(2016) James Kirui et al.   JOURNAL OF VIROLOGY

Emerging Role of PML Nuclear Bodies in Innate Immune Signaling

(2016) Myriam Scherer et al.   JOURNAL OF VIROLOGY

Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes

(2016) M. T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

(2016) Junji Xing et al.   NATURE IMMUNOLOGY

The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion

(2016) Nasser Masroori et al.   Retrovirology

An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

(2016) Ting Yuan et al.   Retrovirology

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

(2016) Christopher M. Murphy et al.   Cell Reports

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

(2016) Preeti Bharaj et al.   PLoS Pathogens

Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

(2016) Jonathan M Wagner et al.   eLife

Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids

(2016) Yen-Li Li et al.   eLife

TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein

(2016) Shanshan Wang et al.   Scientific Reports

TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A

(2016) Wenchun Fan et al.   Scientific Reports

Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

(2015) Qingliang Zheng et al.   CELL RESEARCH

Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A

(2015) Chen Yang et al.   Cellular & Molecular Immunology

TRIM5  requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

(2015) A. J. Fletcher et al.   EMBO JOURNAL

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms

(2015) Ming-Ming Hu et al.   JOURNAL OF IMMUNOLOGY

TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization

(2015) Edward M. Campbell et al.   JOURNAL OF VIROLOGY

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

(2015) Adam J. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

(2015) Filippo Turrini et al.   Retrovirology

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness

(2015) G. Manokaran et al.   SCIENCE

Ubiquitination in the antiviral immune response

(2015) Meredith E. Davis et al.   VIROLOGY

TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner

(2015) Tanja Kahle et al.   Viruses-Basel

The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling

(2015) Atanu Chakraborty et al.   Nature Communications

RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin

(2015) Zinaida Yudina et al.   Cell Reports

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

(2015) Ruth E. Watkinson et al.   PLoS Pathogens

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

(2015) Bishi Fu et al.   PLoS Pathogens

The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon

(2014) Maudry Laurent-Rolle et al.   Cell Host & Microbe

InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins

(2014) Gijs A. Versteeg et al.   CYTOKINE & GROWTH FACTOR REVIEWS

PML control of cytokine signaling

(2014) Ghizlane Maarifi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

(2014) Ricardo Rajsbaum et al.   IMMUNITY

Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses

(2014) F. W. Santiago et al.   JOURNAL OF VIROLOGY

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

Overlapping and Distinct Molecular Determinants Dictating the Antiviral Activities of TRIM56 against Flaviviruses and Coronavirus

(2014) B. Liu et al.   JOURNAL OF VIROLOGY

Functional Evidence for the Involvement of Microtubules and Dynein Motor Complexes in TRIM5 -Mediated Restriction of Retroviruses

(2014) P. Pawlica et al.   JOURNAL OF VIROLOGY

TRIM38 inhibits TNF - and IL-1 -triggered NF- B activation by mediating lysosome-dependent degradation of TAB2/3

(2014) M.-M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice

(2014) David C. Goldstone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer

(2014) J. G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unanchored ubiquitin in virus uncoating

(2014) Ricardo Rajsbaum et al.   SCIENCE

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination

(2014) J. Yan et al.   Journal of Molecular Cell Biology

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9

(2014) Mude Shi et al.   Nature Communications

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

TRIMmunity: The Roles of the TRIM E3-Ubiquitin Ligase Family in Innate Antiviral Immunity

(2013) Ricardo Rajsbaum et al.   JOURNAL OF MOLECULAR BIOLOGY

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

Distinct evolution process among type I interferon in mammals

(2013) Lei Xu et al.   Protein & Cell

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

(2012) Akshay A. D'Cruz et al.   PROTEIN SCIENCE

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

(2012) Caroline Le Sommer et al.   PLoS Neglected Tropical Diseases

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

(2011) Luisa M. Napolitano et al.   BIOCHEMICAL JOURNAL

TRIMming Flavivirus Infection

(2011) Michaela U. Gack   Cell Host & Microbe

TRIM79α, an Interferon-Stimulated Gene Product, Restricts Tick-Borne Encephalitis Virus Replication by Degrading the Viral RNA Polymerase

(2011) R. Travis Taylor et al.   Cell Host & Microbe

FinTRIMs, fish virus-inducible proteins with E3 ubiquitin ligase activity

(2011) Lieke M. van der Aa et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Role of Promyelocytic Leukemia Protein in Host Antiviral Defense

(2011) Marie-Claude Geoffroy et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

TRIM56 Is a Virus- and Interferon-Inducible E3 Ubiquitin Ligase That Restricts Pestivirus Infection

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

Red Queen: from populations to taxa and communities

(2011) Lee Hsiang Liow et al.   TRENDS IN ECOLOGY & EVOLUTION

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

(2010) Hiroyuki Oshiumi et al.   Cell Host & Microbe

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I

(2010) Penghua Wang et al.   NATURE IMMUNOLOGY

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

(2010) K.-i. Arimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

(2010) Cheng Lu et al.   STRUCTURE

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish

(2009) Lieke M van der Aa et al.   BMC BIOLOGY

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

A B-Box 2 Surface Patch Important for TRIM5  Self-Association, Capsid Binding Avidity, and Retrovirus Restriction

(2009) F. Diaz-Griffero et al.   JOURNAL OF VIROLOGY

Ebola Virus Protein VP35 Impairs the Function of Interferon Regulatory Factor-Activating Kinases IKK  and TBK-1

(2009) K. C. Prins et al.   JOURNAL OF VIROLOGY

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells

(2008) Ricardo Rajsbaum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Nonstructural Protein NS2A in Flavivirus Assembly

(2008) J. Y. Leung et al.   JOURNAL OF VIROLOGY

Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?

(2008) Tieu-Lan Chau et al.   TRENDS IN BIOCHEMICAL SCIENCES