The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

(2017) Joschka Willemsen et al.   MOLECULAR CELL

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

(2017) Yuheng Shi et al.   Nature Communications

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

(2017) Jennifer H. Lumb et al.   Cell Reports

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection

(2017) Tingting Feng et al.   Frontiers in Cellular and Infection Microbiology

DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation

(2016) Sathya N. Thulasi Raman et al.   JOURNAL OF VIROLOGY

Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes

(2016) M. T. Sánchez-Aparicio et al.   JOURNAL OF VIROLOGY

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression

(2015) Sanna M. Mäkelä et al.   JOURNAL OF VIROLOGY

Methods for the characterization of stress granules in virus infected cells

(2015) Marc D. Panas et al.   METHODS

DDX6 Orchestrates Mammalian Progenitor Function through the mRNA Degradation and Translation Pathways

(2015) Ying Wang et al.   MOLECULAR CELL

Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

(2014) Guifang Chen et al.   Cell Host & Microbe

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene I

(2014) W. Li et al.   JOURNAL OF VIROLOGY

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway

(2014) Su-Yu Tsai et al.   PLoS Pathogens

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

(2014) Ji-Seung Yoo et al.   PLoS Pathogens

Influenza A Virus Host Shutoff Disables Antiviral Stress-Induced Translation Arrest

(2014) Denys A. Khaperskyy et al.   PLoS Pathogens

DDX6 and its orthologs as modulators of cellular and viral RNA expression

(2014) Dirk H. Ostareck et al.   Wiley Interdisciplinary Reviews-RNA

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer

(2013) D-W Wu et al.   ONCOGENE

Highly Pathogenic H5N1 Influenza A Virus Strains Provoke Heterogeneous IFN-α/β Responses That Distinctively Affect Viral Propagation in Human Cells

(2013) Markus Matthaei et al.   PLoS One

Diversion of stress granules and P-bodies during viral infection

(2013) Lucas C. Reineke et al.   VIROLOGY

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

(2013) Hiroyuki Oshiumi et al.   PLoS Pathogens

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

The NS1 Protein of Influenza A Virus Interacts with Cellular Processing Bodies and Stress Granules through RNA-Associated Protein 55 (RAP55) during Virus Infection

(2012) B. W.-Y. Mok et al.   JOURNAL OF VIROLOGY

Correction: Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple binding of repressed mRNAs by the P-body protein Rck/p54

(2012) M. Ernoult-Lange et al.   RNA

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Influenza A virus inhibits cytoplasmic stress granule formation

(2011) Denys A. Khaperskyy et al.   FASEB JOURNAL

Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

(2011) N. P. Maharaj et al.   JOURNAL OF VIROLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3’ UTR structures

(2011) Alex Michael Ward et al.   RNA Biology

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The Role of Protein Kinase R in the Interferon Response

(2010) Agnieszka Pindel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY