Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

An origin of the immunogenicity of in vitro transcribed RNA

(2018) Xin Mu et al.   NUCLEIC ACIDS RESEARCH

The Abscopal Effect in the Era of Cancer Immunotherapy: a Spontaneous Synergism Boosting Anti-tumor Immunity?

(2018) Zuzana Hlavata et al.   Targeted Oncology

Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

(2018) María E. Rodríguez-Ruiz et al.   TRENDS IN IMMUNOLOGY

cGAS–STING and Cancer: Dichotomous Roles in Tumor Immunity and Development

(2018) Kevin W. Ng et al.   TRENDS IN IMMUNOLOGY

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

(2018) Sandra Iurescia et al.   Frontiers in Immunology

A minimal RNA ligand for potent RIG-I activation in living mice

(2018) Melissa M. Linehan et al.   Science Advances

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

(2018) David L Elion et al.   CANCER RESEARCH

Systematic editing of synthetic RIG-I ligands to produce effective antiviral and anti-tumor RNA immunotherapies

(2018) Janghyun Lee et al.   NUCLEIC ACIDS RESEARCH

Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus

(2018) Valia T. Mihaylova et al.   Cell Reports

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

(2018) Dacquin M. Kasumba et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

(2017) Houbao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants

(2017) Meleri Jones et al.   JOURNAL OF MEDICAL VIROLOGY

UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model

(2017) Jake Wang et al.   Pigment Cell & Melanoma Research

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The anticancer functions of RIG-I–like receptors, RIG-I and MDA5, and their applications in cancer therapy

(2017) Yuanbing Wu et al.   Translational Research

RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation

(2017) Christina Engel et al.   Cancer Immunology Research

Activation of the MDA-5–IPS-1 Viral Sensing Pathway Induces Cancer Cell Death and Type I IFN-Dependent Antitumor Immunity

(2016) Xiaofei Yu et al.   CANCER RESEARCH

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

(2016) Henrique Lemos et al.   CANCER RESEARCH

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

(2016) Katrina Meeth et al.   Pigment Cell & Melanoma Research

CpG-induced antitumor immunity requires IL-12 in expansion of effector cells and down-regulation of PD-1

(2016) Peng Yin et al.   Oncotarget

Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs

(2016) Diana Rose E. Ranoa et al.   Oncotarget

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

(2016) Tiejun Li et al.   Scientific Reports

Activated STING enhances Tregs infiltration in the HPV-related carcinogenesis of tongue squamous cells via the c-jun/CCL22 signal

(2015) Ding Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists

(2015) Cindy Chiang et al.   JOURNAL OF VIROLOGY

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells

(2014) P Duewell et al.   CELL DEATH AND DIFFERENTIATION

An evolving arsenal: viral RNA detection by RIG-I-like receptors

(2014) Megan E Fitzgerald et al.   CURRENT OPINION IN MICROBIOLOGY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Therapeutic Efficacy of Bifunctional siRNA Combining TGF- 1 Silencing with RIG-I Activation in Pancreatic Cancer

(2013) J. Ellermeier et al.   CANCER RESEARCH

Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

A structure-based model of RIG-I activation

(2012) D. Kolakofsky et al.   RNA

Targeted Activation of RNA Helicase Retinoic Acid-Inducible Gene-I Induces Proimmunogenic Apoptosis of Human Ovarian Cancer Cells

(2010) K. Kubler et al.   CANCER RESEARCH

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE