LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells

(2018) Annemarthe G van der Veen et al.   EMBO JOURNAL

Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses

(2017) Lei Hei et al.   HEPATOLOGY

PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization

(2017) Pak-Yin Lui et al.   JOURNAL OF IMMUNOLOGY

Nonencapsidated 5′ Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5

(2017) Marie Mura et al.   JOURNAL OF VIROLOGY

The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation

(2017) Zhen Ding et al.   Oncotarget

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT

(2017) Stephanie Dabo et al.   Scientific Reports

Questioning antiviral RNAi in mammals

(2017) Benjamin R. tenOever   Nature Microbiology

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection

(2016) Akihiko Komuro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells

(2016) Pierre V Maillard et al.   EMBO JOURNAL

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

(2016) Raul Y Sanchez David et al.   eLife

ATP-Dependent Effector-like Functions of RIG-I-like Receptors

(2015) Hui Yao et al.   MOLECULAR CELL

MDA5—filament, dynamics and disease

(2015) Yoandris del Toro Duany et al.   Current Opinion in Virology

Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs

(2015) Alex Heyam et al.   Wiley Interdisciplinary Reviews-RNA

Protective Role of LGP2 in Influenza Virus Pathogenesis

(2014) Mustapha Si-Tahar et al.   JOURNAL OF INFECTIOUS DISEASES

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells

(2014) Simon Runge et al.   PLoS Pathogens

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

(2014) Safia Deddouche et al.   eLife

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Dicer's role as an antiviral: still an enigma

(2013) Christopher R MacKay et al.   CURRENT OPINION IN IMMUNOLOGY

Homologous RIG-I-like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanisms

(2013) X. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A recombinant measles vaccine expressing chikungunya virus-like particles is strongly immunogenic and protects mice from lethal challenge with chikungunya virus

(2013) Samantha Brandler et al.   VACCINE

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

(2013) Marianne Lucas-Hourani et al.   PLoS Pathogens

A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

(2013) Alyson Ashe et al.   eLife

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2)

(2012) Annie M. Bruns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

RO 90-7501 Enhances TLR3 and RLR Agonist Induced Antiviral Response

(2012) Fang Guo et al.   PLoS One

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

(2012) Qian Feng et al.   Cell Reports

Regulators of innate immunity as novel targets for panviral therapeutics

(2012) Salwa Es-Saad et al.   Current Opinion in Virology

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

The selective footprints of viral pressures at the human RIG-I-like receptor family

(2011) Estelle Vasseur et al.   HUMAN MOLECULAR GENETICS

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Ambivalent Role of the Innate Immune Response in Rabies Virus Pathogenesis

(2011) D. Chopy et al.   JOURNAL OF VIROLOGY

Proteomic Analysis of Virus-Host Interactions in an Infectious Context Using Recombinant Viruses

(2011) Anastassia V. Komarova et al.   MOLECULAR & CELLULAR PROTEOMICS

Pharmacological and Biological Antiviral Therapeutics for Cardiac Coxsackievirus Infections

(2011) Henry Fechner et al.   MOLECULES

Benchmarking a luciferase complementation assay for detecting protein complexes

(2011) Patricia Cassonnet et al.   NATURE METHODS

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections

(2010) Guanjun Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo

(2010) Kari Ann Shirey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2

(2009) Darja Bamming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE