USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation

(2012) FangFang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I-Mediated IFN-  Production and Antiviral Response by Targeting NAP1

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

The yin and yang of viruses and interferons

(2012) Ben X. Wang et al.   TRENDS IN IMMUNOLOGY

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

(2011) Ning Xiao et al.   BIOCHEMICAL JOURNAL

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

(2011) Y-H Fan et al.   CELL DEATH AND DIFFERENTIATION

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

(2011) Xinna Zhang et al.   EMBO JOURNAL

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I

(2011) H. Oshiumi et al.   JOURNAL OF BIOCHEMISTRY

ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner

(2011) Yong-Kang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling

(2010) Rui Chen et al.   CELL RESEARCH

Peroxisome Proliferator-activated Receptor γ Negatively Regulates IFN-β Production in Toll-like Receptor (TLR) 3- and TLR4-stimulated Macrophages by Preventing Interferon Regulatory Factor 3 Binding to the IFN-β Promoter

(2010) Wei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

(2010) M. U. Gack et al.   JOURNAL OF VIROLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I-like receptors: Sensing and responding to RNA virus infection

(2009) Peyman Nakhaei et al.   SEMINARS IN IMMUNOLOGY

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

TNF-mediated inflammatory disease

(2007) JR Bradley   JOURNAL OF PATHOLOGY

UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I

(2007) Kei-Ichiro Arimoto et al.   MOLECULAR IMMUNOLOGY