Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stagePlasmodium bergheiANKA

(2013) Jennifer Palomo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

(2013) Hideaki Ohyagi et al.   IMMUNITY

IFNAR1 Controls Progression to Cerebral Malaria in Children and CD8+ T Cell Brain Pathology in Plasmodium berghei-Infected Mice

(2013) E. A. Ball et al.   JOURNAL OF IMMUNOLOGY

Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS

(2013) Anna Rosanas-Urgell et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality

(2012) Prakasha Kempaiah et al.   HUMAN GENETICS

Innate recognition of malarial parasites by mammalian hosts

(2012) Peter Liehl et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Splenic Red Pulp Macrophages Produce Type I Interferons as Early Sentinels of Malaria Infection but Are Dispensable for Control

(2012) Charles C. Kim et al.   PLoS One

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

(2011) Shruti Sharma et al.   IMMUNITY

Caspase-1 Activation of Interleukin-1β (IL-1β) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria

(2011) Maximilian Kordes et al.   INFECTION AND IMMUNITY

Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii

(2011) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

(2010) X. Wu et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ-central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria

(2010) Matthew B. B. McCall et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation

(2010) Esther Bettiol et al.   MALARIA JOURNAL

Host resistance to malaria: using mouse models to explore the host response

(2010) Rhea Longley et al.   MAMMALIAN GENOME

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

(2009) Thornik Reimer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MAPK-activated Protein Kinase 2 Differentially RegulatesPlasmodium falciparumGlycosylphosphatidylinositol-induced Production of Tumor Necrosis Factor-α and Interleukin-12 in Macrophages

(2009) Jianzhong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence

(2009) H. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria primes the innate immune response due to interferon-  induced enhancement of toll-like receptor expression and function

(2009) B. S. Franklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history

(2008) P FITZGERALDBOCARSLY et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity

(2008) L ERDMAN et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY