PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

(2017) Ian T. Lamborn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway

(2017) Lian-Feng Li et al.   JOURNAL OF VIROLOGY

Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein

(2017) Vidyanath Chaudhary et al.   JOURNAL OF VIROLOGY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

(2016) Alissa M. Pham et al.   PLoS Pathogens

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

(2016) Raul Y Sanchez David et al.   eLife

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

(2016) Pak-Yin Lui et al.   Emerging Microbes & Infections

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

(2015) Jade Louber et al.   BMC BIOLOGY

PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine

(2015) Ting-Hin Ho et al.   JOURNAL OF VIROLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs

(2015) Alex Heyam et al.   Wiley Interdisciplinary Reviews-RNA

Sensing viral invasion by RIG-I like receptors

(2014) Ji-Seung Yoo et al.   CURRENT OPINION IN MICROBIOLOGY

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

(2014) Masahide Funabiki et al.   IMMUNITY

CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells

(2014) K.-S. Yuen et al.   JOURNAL OF GENERAL VIROLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host Factor

(2014) K. Tawaratsumida et al.   JOURNAL OF VIROLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

Antiviral innate immunity and stress granule responses

(2014) Koji Onomoto et al.   TRENDS IN IMMUNOLOGY

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

(2013) Priya Luthra et al.   Cell Host & Microbe

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Suppression of PACT-Induced Type I Interferon Production by Herpes Simplex Virus 1 Us11 Protein

(2013) C. Kew et al.   JOURNAL OF VIROLOGY

MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon

(2013) M. A. Langereis et al.   JOURNAL OF VIROLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses

(2012) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

MDA5 assembles into a polar helical filament on dsRNA

(2012) I. C. Berke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Double-Stranded RNA-Binding Protein PACT Functions as a Cellular Activator of RIG-I to Facilitate Innate Antiviral Response

(2011) Kin-Hang Kok et al.   Cell Host & Microbe

Negative Regulation of Interferon-β Gene Expression during Acute and Persistent Virus Infections

(2011) Junqiang Ye et al.   PLoS One

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of IFN-β expression by a viral mRNA through RNase L and MDA5

(2011) Priya Luthra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains

(2009) Kiyohiro Takahasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 Regulates the Function of Argonaute 2 and Its Recruitment to Stress Granules and P-Bodies

(2009) Justin M. Pare et al.   MOLECULAR BIOLOGY OF THE CELL

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of PACT in Mediating Gene Induction, PKR Activation, and Apoptosis in Response to Diverse Stimuli

(2007) Joao T. Marques et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH