Autoimmunity gene IRGM suppresses cGAS ‐ STING and RIG ‐I‐ MAVS signaling to control interferon response

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

(2019) Subhash Mehto et al.   MOLECULAR CELL

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

(2019) Aurora Scrivo et al.   Nature Communications

Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

(2019) Nan Yao et al.   Cell Death & Disease

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

(2019) Huifang Xian et al.   Autophagy

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

(2019) Mai Tram Vo et al.   Nature Communications

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

(2018) Alexandra Coomans de Brachène et al.   DIABETOLOGIA

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Regulation of innate immune functions by guanylate-binding proteins

(2018) Gerrit J.K. Praefcke   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

(2018) Suresh Kumar et al.   JOURNAL OF CELL BIOLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

(2018) Mohammad Samie et al.   NATURE IMMUNOLOGY

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

(2018) Teneema Kuriakose et al.   TRENDS IN IMMUNOLOGY

TRIM Proteins and Their Roles in Antiviral Host Defenses

(2018) Michiel van Gent et al.   Annual Review of Virology

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

(2018) Cynthia Louis et al.   Frontiers in Immunology

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

Mitochondrial dsRNA: A New DAMP for MDA5

(2018) Andreas Linder et al.   DEVELOPMENTAL CELL

TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy

(2018) Kautilya Kumar Jena et al.   EMBO JOURNAL

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

A SUMOylation-dependent switch of RAB7 governs intracellular life and pathogenesis of Salmonella Typhimurium

(2018) Gayatree Mohapatra et al.   JOURNAL OF CELL SCIENCE

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

(2018) Katerina Gkirtzimanaki et al.   Cell Reports

Type I Interferons in Autoimmune Disease

(2018) Mary K. Crow et al.   Annual Review of Pathology-Mechanisms of Disease

The IRGM rs10065172 variant increases the risk for steatosis but not for liver damage progression in Italian obese children

(2017) Giulia Bellini et al.   JOURNAL OF HEPATOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M

(2017) Marianne D. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of extracellular histone in organ injury

(2017) Eleanor Silk et al.   Cell Death & Disease

T cells display mitochondria hyperpolarization in human type 1 diabetes

(2017) Jing Chen et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Structure biology of selective autophagy receptors

(2016) Byeong-Won Kim et al.   BMB Reports

Autophagy-related IRGM genes confer susceptibility to ankylosing spondylitis in a Chinese female population: a case–control study

(2016) Q Xia et al.   GENES AND IMMUNITY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy

(2016) Yu-Cheng Lin et al.   JOURNAL OF HEPATOLOGY

Nucleic acid-mediated autoinflammation and autoimmunity—type I interferonopathies

(2016) Min Ae Lee-Kirsch et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Cytosolic Innate Immune Sensing and Signaling upon Infection

(2016) Lilliana Radoshevich et al.   Frontiers in Microbiology

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

RIG-I-like receptors and autoimmune diseases

(2015) Hiroki Kato et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy

(2015) H Dong et al.   ONCOGENE

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

(2015) Martina Haller et al.   Autophagy

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis

(2014) Tomonori Kimura et al.   PLoS One

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

(2014) K. Kuniyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release and activity of histone in diseases

(2014) R Chen et al.   Cell Death & Disease

Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5

(2014) Stephanie Reikine et al.   Frontiers in Immunology

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Selective autophagy

(2013) Steingrim Svenning et al.   Essays in Biochemistry

Fueling autoimmunity: type I interferon in autoimmune diseases

(2013) Jeremy Di Domizio et al.   Expert Review of Clinical Immunology

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

(2013) Chang Shu et al.   STRUCTURE

Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke

(2012) Shuyu He et al.   Autophagy

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

What comes first, misshape or dysfunction? The view from metabolic excess

(2012) Chad A. Galloway et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

(2012) Koji Onomoto et al.   PLoS One

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

(2011) Patrick Brest et al.   NATURE GENETICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells

(2010) Hongwei Xu et al.   FASEB JOURNAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The complement system in systemic autoimmune disease

(2009) Min Chen et al.   JOURNAL OF AUTOIMMUNITY

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death and Resurrection of the Human IRGM Gene

(2009) Cemalettin Bekpen et al.   PLoS Genetics

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS