Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase

(2018) Lu-Yi Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation

(2018) Fei Dong et al.   Scientific Reports

UbiA prenyltransferase domain–containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids

(2017) Marc M. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver

(2016) Seonghwan Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi

(2016) Marc M. Schumacher et al.   JOURNAL OF LIPID RESEARCH

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

(2016) Marleen Schonewille et al.   JOURNAL OF LIPID RESEARCH

Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases

(2016) Weikai Li   TRENDS IN BIOCHEMICAL SCIENCES

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

(2016) Kelly M. Cautivo et al.   Molecular Metabolism

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

(2015) Marc M Schumacher et al.   eLife

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Functional Characterization of the Vitamin K2 Biosynthetic Enzyme UBIAD1

(2015) Yoshihisa Hirota et al.   PLoS One

Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

(2014) Lindsey L. Morris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin K2 Biosynthetic Enzyme, UBIAD1 Is Essential for Embryonic Development of Mice

(2014) Kimie Nakagawa et al.   PLoS One

Structural Insights into Ubiquinone Biosynthesis in Membranes

(2014) W. Cheng et al.   SCIENCE

Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1

(2014) Hua Huang et al.   PLOS BIOLOGY

Menadione (Vitamin K3) Is a Catabolic Product of Oral Phylloquinone (Vitamin K1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K2) in Rats

(2013) Yoshihisa Hirota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

(2013) Matthew R. McFarlane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

(2013) Rania Elsabrouty et al.   MOLECULAR BIOLOGY OF THE CELL

The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes

(2012) Michael L. Nickerson et al.   HUMAN MUTATION

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

(2012) Jeffrey G. McDonald et al.   JOURNAL OF LIPID RESEARCH

Preparation of Mouse Embryonic Fibroblast Cells Suitable for Culturing Human Embryonic and Induced Pluripotent Stem Cells

(2012) Justyna Jozefczuk et al.   Jove-Journal of Visualized Experiments

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

(2011) Y. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

(2010) Bret M. Evers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

(2010) Kimie Nakagawa et al.   NATURE

Schnyder corneal dystrophy

(2009) Jayne S Weiss   CURRENT OPINION IN OPHTHALMOLOGY

Corneal dystrophies

(2009) Gordon K Klintworth   Orphanet Journal of Rare Diseases

The Discovery of Statins

(2008) Thomas P. Stossel   CELL

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism