Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER

(2018) Jonathan R. Friedman et al.   DEVELOPMENTAL CELL

Is ABCA1 a lipid transfer protein?

(2018) Michael C. Phillips   JOURNAL OF LIPID RESEARCH

Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites

(2018) Junsen Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle

(2017) Aby Grabon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein

(2017) Rabih Darwiche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain

(2017) Jennifer Prashek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–function insights into direct lipid transfer between membranes by Mmm1–Mdm12 of ERMES

(2017) Shin Kawano et al.   JOURNAL OF CELL BIOLOGY

Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane

(2017) David B. Iaea et al.   MOLECULAR BIOLOGY OF THE CELL

The sterol-binding activity of PATHOGENESIS-RELATED PROTEIN 1 reveals the mode of action of an antimicrobial protein

(2017) Jordi Gamir et al.   PLANT JOURNAL

Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites

(2017) Hanbin Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Speed Limits for Nonvesicular Intracellular Sterol Transport

(2017) Jeremy S. Dittman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Advances on the Transfer of Lipids by Lipid Transfer Proteins

(2017) Louise H. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Piecing Together the Patchwork of Contact Sites

(2017) Alberto T. Gatta et al.   TRENDS IN CELL BIOLOGY

ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P 2) and regulate its level at the plasma membrane

(2017) Rajesh Ghai et al.   Nature Communications

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System

(2017) Kexin Zhao et al.   Cell Reports

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

(2017) Elisa Balboa et al.   Redox Biology

Trials and Tribulations of CETP Inhibitors

(2017) Alan R. Tall et al.   CIRCULATION RESEARCH

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage

(2017) Hans Vienken et al.   Scientific Reports

Lipid transfer proteins do their thing anchored at membrane contact sites… but what is their thing?

(2016) Louise H. Wong et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism

(2016) Konrad Sandhoff   BIOCHIMIE

Active membrane cholesterol as a physiological effector

(2016) Yvonne Lange et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria

(2016) Non Miyata et al.   JOURNAL OF CELL BIOLOGY

MICOS and phospholipid transfer by Ups2–Mdm35 organize membrane lipid synthesis in mitochondria

(2016) Mari J. Aaltonen et al.   JOURNAL OF CELL BIOLOGY

Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP

(2016) Matthias E. Lauer et al.   JOURNAL OF STRUCTURAL BIOLOGY

Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. annua

(2016) Bo Wang et al.   METABOLIC ENGINEERING

Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins

(2016) Jin Huang et al.   MOLECULAR BIOLOGY OF THE CELL

Control of plasma membrane lipid homeostasis by the extended synaptotagmins

(2016) Yasunori Saheki et al.   NATURE CELL BIOLOGY

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

(2016) Suguru Okuda et al.   NATURE REVIEWS MICROBIOLOGY

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

(2016) Antonella Chiapparino et al.   PROGRESS IN LIPID RESEARCH

Structural and Functional Characterization of the LPS Transporter LptDE from Gram-Negative Pathogens

(2016) Istvan Botos et al.   STRUCTURE

Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function

(2016) Brent W. Simpson et al.   mBio

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

(2015) Lucian Albulescu et al.   ANTIVIRAL RESEARCH

STARD4 Membrane Interactions and Sterol Binding

(2015) David B. Iaea et al.   BIOCHEMISTRY

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex

(2015) F. Yu et al.   EMBO REPORTS

Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes

(2015) X. Miliara et al.   EMBO REPORTS

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

(2015) Andrew P. AhYoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes

(2015) Joachim Moser von Filseck et al.   Nature Communications

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

(2015) Alberto T Gatta et al.   eLife

Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent

(2015) Christian Seutter von Loetzen et al.   PLoS One

Shared functions of plant and mammalian StAR-related lipid transfer (START) domains in modulating transcription factor activity

(2014) Kathrin Schrick et al.   BMC BIOLOGY

Phosphoregulation of the Ceramide Transport Protein CERT at Serine 315 in the Interaction with VAMP-associated Protein (VAP) for Inter-organelle Trafficking of Ceramide in Mammalian Cells

(2014) Keigo Kumagai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

(2014) William A. Prinz   JOURNAL OF CELL BIOLOGY

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature

(2014) Yading Ling et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer

(2014) Curtis M. Schauder et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Insights into the mechanisms of sterol transport between organelles

(2013) Bruno Mesmin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

(2013) Kenji Maeda et al.   NATURE

Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins

(2013) Junsen Tong et al.   STRUCTURE

The Biochemical Basis and Clinical Evidence of Food Allergy Due to Lipid Transfer Proteins: A Comprehensive Review

(2012) R. Christopher Van Winkle et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

Yeast as a model system for studying lipid homeostasis and function

(2012) Aline X.S. Santos et al.   FEBS LETTERS

Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1) Binds and Transfers Phosphatidic Acid

(2012) Kathryn Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein

(2012) Lei Zhang et al.   Nature Chemical Biology

Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins

(2012) V. Choudhary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

(2012) S. Okuda et al.   SCIENCE

Intramitochondrial Transport of Phosphatidic Acid in Yeast by a Lipid Transfer Protein

(2012) M. Connerth et al.   SCIENCE

Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?

(2011) Shamshad Cockcroft et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

STARD4 abundance regulates sterol transport and sensing

(2011) Bruno Mesmin et al.   MOLECULAR BIOLOGY OF THE CELL

Osh Proteins Regulate Membrane Sterol Organization but Are Not Required for Sterol Movement Between the ER and PM

(2011) Alexander G. Georgiev et al.   TRAFFIC

Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria

(2010) Klaus O. Kopec et al.   BIOINFORMATICS

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

(2010) Michael L. Wang et al.   Cell Metabolism

Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export Pathway inEscherichia coli

(2010) An X. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function

(2010) Sebastian Zeissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membrane

(2009) J. C. Malinverni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Structure of the Conserved Gram-Negative Lipopolysaccharide Transport Protein A and Mutagenesis Analysis

(2008) Michael D.L. Suits et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily

(2008) Gabriel Schaaf et al.   MOLECULAR CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Plant Defense Elicitor Cryptogein Stimulates Clathrin-Mediated Endocytosis Correlated with Reactive Oxygen Species Production in Bright Yellow-2 Tobacco Cells

(2008) N. Leborgne-Castel et al.   PLANT PHYSIOLOGY

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA