IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)

(2012) Hai Thi Do et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

(2012) Yan Wang et al.   JOURNAL OF LIPID RESEARCH

Imaging LDL Receptor Oligomerization during Endocytosis Using a Co-internalization Assay

(2011) Peng Zou et al.   ACS Chemical Biology

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

(2011) Vincenzo Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

(2011) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Shaping development with ESCRTs

(2011) Tor Erik Rusten et al.   NATURE CELL BIOLOGY

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

(2011) A. C. Calkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local clustering of transferrin receptors promotes clathrin-coated pit initiation

(2010) Allen P. Liu et al.   JOURNAL OF CELL BIOLOGY

Reduced VLDL clearance inApoe−/−Npc1−/−mice is associated with increasedPcsk9andIdolexpression and decreased hepatic LDL-receptor levels

(2010) Minako Ishibashi et al.   JOURNAL OF LIPID RESEARCH

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRT machinery at a glance

(2009) T. Wollert et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of clathrin-independent endocytosis

(2009) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

Gephyrin Oligomerization Controls GlyR Mobility and Synaptic Clustering

(2009) M. Calamai et al.   JOURNAL OF NEUROSCIENCE

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide

(2008) LiXin Shan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance

(2008) Libin Liu et al.   Cell Metabolism

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

PCSK9: a convertase that coordinates LDL catabolism

(2008) Jay D. Horton et al.   JOURNAL OF LIPID RESEARCH

Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking

(2007) Camilla Raiborg et al.   EXPERIMENTAL CELL RESEARCH