mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 30, Pages 7999-8004
Publisher
Proceedings of the National Academy of Sciences
Online
2017-07-11
DOI
10.1073/pnas.1705304114
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery
- (2017) Kristin Dauner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol
- (2017) Rodney Elwood Infante et al. eLife
- Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
- (2015) Feiran Lu et al. eLife
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice
- (2012) Ding Ai et al. JOURNAL OF CLINICAL INVESTIGATION
- An Essential Role of Hrs/Vps27 in Endosomal Cholesterol Trafficking
- (2012) Ximing Du et al. Cell Reports
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Regulation of the autophagy initiating kinase ULK1 by nutrients: Roles of mTORC1 and AMPK
- (2011) Joungmok Kim et al. CELL CYCLE
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics
- (2010) Anton I. Rosenbaum et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
- (2010) Shomit Sengupta et al. NATURE
- Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
- (2010) Shijie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell cholesterol homeostasis: Mediation by active cholesterol
- (2010) Theodore L. Steck et al. TRENDS IN CELL BIOLOGY
- Discovery of Atg5/Atg7-independent alternative macroautophagy
- (2009) Yuya Nishida et al. NATURE
- Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
- (2008) Arun Radhakrishnan et al. Cell Metabolism
- Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
- (2008) Pazit Polak et al. Cell Metabolism
- NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
- (2008) R. E. Infante et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started