Is ABCA1 a lipid transfer protein?

Membrane microdomains and the regulation of HDL biogenesis

(2018) Jacques Genest et al.   CURRENT OPINION IN LIPIDOLOGY

α-Synuclein Regulates Neuronal Cholesterol Efflux

(2017) Jen-Hsiang Hsiao et al.   MOLECULES

A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state

(2017) John T Melchior et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state

(2017) John T Melchior et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Caveolin-1 facilitates internalization and degradation of ABCA1 and probucol oxidative products interfere with this reaction to increase HDL biogenesis

(2016) Rui Lu et al.   ATHEROSCLEROSIS

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly

(2016) Duyen Quach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL AssemblyNovelty and Significance

(2016) Kailash Gulshan et al.   CIRCULATION RESEARCH

ABCA1 agonist peptides for the treatment of disease

(2016) John K. Bielicki   CURRENT OPINION IN LIPIDOLOGY

Probing the C-terminal domain of lipid-free apoA-I demonstrates the vital role of the H10B sequence repeat in HDL formation

(2016) Xiaohu Mei et al.   JOURNAL OF LIPID RESEARCH

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel Pathways of Apolipoprotein A-I Metabolism in High-Density Lipoprotein of Different Sizes in Humans

(2015) Carlos O. Mendivil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1

(2015) Shimpei Itoh et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Preferential incorporation of shorter and less unsaturated acyl phospholipids into high density lipoprotein-like particles in the ABCA1- and ABCA7-mediated biogenesis with apoA-I

(2015) Noriko Hotta et al.   CHEMISTRY AND PHYSICS OF LIPIDS

HDL Particle Size Is a Critical Determinant of ABCA1-Mediated Macrophage Cellular Cholesterol ExportNovelty and Significance

(2015) Xian-Ming Du et al.   CIRCULATION RESEARCH

Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum

(2015) Yoshio Yamauchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

(2015) Yoshio Yamauchi et al.   JOURNAL OF LIPID RESEARCH

Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly

(2015) Jere P. Segrest et al.   STRUCTURE

Impact of Phospholipid Transfer Protein on Nascent High-Density Lipoprotein Formation and Remodeling

(2014) Ailing Ji et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ATP-binding cassette transporter A1

(2014) Miranda Van Eck   CURRENT OPINION IN LIPIDOLOGY

Molecular Mechanisms of Cellular Cholesterol Efflux

(2014) Michael C. Phillips   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane

(2014) Osamu Sano et al.   PLoS One

ABCA1 Mediates Unfolding of Apolipoprotein AI N Terminus on the Cell Surface Before Lipidation and Release of Nascent High-Density Lipoprotein

(2013) Shuhui Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks

(2013) Xin-Min Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability

(2013) Nicholas N. Lyssenko et al.   FASEB JOURNAL

Differential Phospholipid Substrates and Directional Transport by ATP-binding Cassette Proteins ABCA1, ABCA7, and ABCA4 and Disease-causing Mutants

(2013) Faraz Quazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms Responsible for the Compositional Heterogeneity of Nascent High Density Lipoprotein

(2013) Sissel Lund-Katz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin Depletion Impairs Anionic Phospholipid Inward Translocation and Induces Cholesterol Efflux

(2013) Kailash Gulshan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging

(2013) K. O. Nagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of ABC transporters in lipid transport and human disease

(2013) Elizabeth J. Tarling et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding

(2012) Kohjiro Nagao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol Efflux and Atheroprotection

(2012) Robert S. Rosenson et al.   CIRCULATION

New insights into the determination of HDL structure by apolipoproteins

(2012) Michael C. Phillips   JOURNAL OF LIPID RESEARCH

Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers

(2012) Mary G. Sorci-Thomas et al.   JOURNAL OF LIPID RESEARCH

A Novel Compound Inhibits Reconstituted High-Density Lipoprotein Assembly and Blocks Nascent High-Density Lipoprotein Biogenesis Downstream of Apolipoprotein AI Binding to ATP-Binding Cassette Transporter A1–Expressing Cells

(2011) Nicholas N. Lyssenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Homology modeling and functional testing of an ABCA1 mutation causing Tangier disease

(2011) Rachel J. Suetani et al.   ATHEROSCLEROSIS

Lysine residues of ABCA1 are required for the interaction with apoA-I

(2011) Kohjiro Nagao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality

(2011) Nicholas N. Lyssenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT

(2011) Ian Tietjen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of ABCA1 functions by signaling pathways

(2011) Yuhua Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann–Pick C2 but not Niemann–Pick C1 protein

(2011) Emmanuel Boadu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ATP-Binding Cassette Transporters A1 and G1, HDL Metabolism, Cholesterol Efflux, and Inflammation: Important Targets for the Treatment of Atherosclerosis

(2011) Dan Ye et al.   CURRENT DRUG TARGETS

Lipid transport by mammalian ABC proteins

(2011) Faraz Quazi et al.   Essays in Biochemistry

Impact of Self-association on Function of Apolipoprotein A-I

(2011) Shobini Jayaraman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor β (LXRβ) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation

(2011) Masako Hozoji-Inada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding

(2011) Kohjiro Nagao et al.   JOURNAL OF LIPID RESEARCH

Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis

(2011) Iulia Iatan et al.   JOURNAL OF LIPID RESEARCH

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments

(2011) Michael F. Beers et al.   JOURNAL OF LIPID RESEARCH

Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis

(2011) Amit V. Khera et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curvature-Driven Lipid Sorting in Biomembranes

(2011) A. Callan-Jones et al.   Cold Spring Harbor Perspectives in Biology

Calmodulin Interacts With ATP Binding Cassette Transporter A1 to Protect From Calpain-Mediated Degradation and Upregulates High-Density Lipoprotein Generation

(2010) Noriyuki Iwamoto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acidic Extracellular Environments Strongly Impair ABCA1-Mediated Cholesterol Efflux From Human Macrophage Foam Cells

(2010) Miriam Lee-Rueckert et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages

(2010) Margarita de la Llera-Moya et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-density lipoprotein heterogeneity and function in reverse cholesterol transport

(2010) George H Rothblat et al.   CURRENT OPINION IN LIPIDOLOGY

Influence of Apolipoprotein (Apo) A-I Structure on Nascent High Density Lipoprotein (HDL) Particle Size Distribution

(2010) Charulatha Vedhachalam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Discoidal Pre-β1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1

(2009) Elda Favari et al.   BIOCHEMISTRY

Lipid dependence of ABC transporter localization and function

(2009) Karin Klappe et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function

(2009) Roshni R. Singaraja et al.   CIRCULATION RESEARCH

The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter

(2009) Erik Procko et al.   FASEB JOURNAL

Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma membrane: a biophysical study

(2009) Ana Zarubica et al.   FASEB JOURNAL

Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation

(2009) Yuya Azuma et al.   GENES TO CELLS

Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1

(2009) Masako Hozoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation

(2009) Kohjiro Nagao et al.   JOURNAL OF LIPID RESEARCH

Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis

(2009) Reijiro Arakawa et al.   JOURNAL OF LIPID RESEARCH

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis

(2009) Dana Bailey et al.   JOURNAL OF LIPID RESEARCH

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I

(2008) John B. Massey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cellular cholesterol substrate pools for adenosine-triphosphate cassette transporter A1-dependent high-density lipoprotein formation

(2008) Emmanuel Boadu et al.   CURRENT OPINION IN LIPIDOLOGY

Asymmetry in the Lipid Affinity of Bihelical Amphipathic Peptides

(2008) Amar A. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Interaction of Nuclear Liver X Receptor-β with ABCA1 Modulates Cholesterol Efflux

(2008) Masako Hozoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Analysis of ABCA1-dependent Compartmentalization and Trafficking of Apolipoprotein A-I

(2008) Houssein Hajj Hassan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding Cassette A1-mediated Lipidation of Apolipoprotein A-I Occurs at the Plasma Membrane and Not in the Endocytic Compartments

(2008) Maxime Denis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and properties of preβ-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I

(2008) Phu T. Duong et al.   JOURNAL OF LIPID RESEARCH

ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity

(2008) Shilpi Nandi et al.   JOURNAL OF LIPID RESEARCH

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation

(2008) Ashley M. Vaughan et al.   JOURNAL OF LIPID RESEARCH

Conformational change of apolipoprotein A-I and HDL formation from model membranes under intracellular acidic conditions

(2008) Masakazu Fukuda et al.   JOURNAL OF LIPID RESEARCH

Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL

(2008) Anny Mulya et al.   JOURNAL OF LIPID RESEARCH

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux

(2008) Sandhya Sankaranarayanan et al.   JOURNAL OF LIPID RESEARCH

An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages

(2008) Loren E. Faulkner et al.   JOURNAL OF LIPID RESEARCH