The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
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Title
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
Authors
Keywords
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Journal
eLife
Volume 7, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2018-12-13
DOI
10.7554/elife.40009
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Note: Only part of the references are listed.- MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins
- (2018) Sandra Stefanovic‐Barrett et al. EMBO REPORTS
- Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase
- (2018) Lu-Yi Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- “Mallostery”—ligand-dependent protein misfolding enables physiological regulation by ERAD
- (2018) Margaret A Wangeline et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase
- (2018) Brittany M. Johnson et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation
- (2017) Michael L. van de Weijer et al. JOURNAL OF CELL SCIENCE
- Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
- (2017) David W. Morgens et al. Nature Communications
- Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
- (2017) Li Zhang et al. eLife
- Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
- (2017) Emma C. L. Cook et al. PLoS One
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens
- (2016) Richard T. Timms et al. Nature Communications
- Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation
- (2016) Masayuki Kaneko et al. Scientific Reports
- Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I
- (2015) D.J.H. van den Boomen et al. MOLECULAR IMMUNOLOGY
- Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141
- (2015) Jye-Lin Hsu et al. PLoS Pathogens
- Dual Functions of theTrans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation
- (2014) Takeshi Wakashima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Cleaning up in the endoplasmic reticulum: ubiquitin in charge
- (2014) John C Christianson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation
- (2014) Michael L. van de Weijer et al. Nature Communications
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis
- (2012) Tong-Fei Liu et al. Cell Metabolism
- The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation
- (2012) Florencia Cano et al. EMBO JOURNAL
- Dual functions of Insig proteins in cholesterol homeostasis
- (2012) Xiao-Ying Dong et al. Lipids in Health and Disease
- Unassembled CD147 is an endogenous endoplasmic reticulum–associated degradation substrate
- (2012) Ryan E. Tyler et al. MOLECULAR BIOLOGY OF THE CELL
- Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
- (2012) Yien Che Tsai et al. MOLECULAR BIOLOGY OF THE CELL
- Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes
- (2012) Youngah Jo et al. MOLECULAR BIOLOGY OF THE CELL
- Improving FRET dynamic range with bright green and red fluorescent proteins
- (2012) Amy J Lam et al. NATURE METHODS
- Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control
- (2011) Elizabeth J. Klemm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defining human ERAD networks through an integrative mapping strategy
- (2011) John C. Christianson et al. NATURE CELL BIOLOGY
- HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation
- (2011) Marian L. Burr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8
- (2011) Y. Jo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distribution and Functions of Sterols and Sphingolipids
- (2011) J. T. Hannich et al. Cold Spring Harbor Perspectives in Biology
- Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2
- (2010) Honghua Miao et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Ancient Ubiquitous Protein 1 (AUP1) Localizes to Lipid Droplets and Binds the E2 Ubiquitin Conjugase G2 (Ube2g2) via Its G2 Binding Region
- (2010) Johanna Spandl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insulin-induced gene: A new regulator in lipid metabolism
- (2010) Xiao-Ying Dong et al. PEPTIDES
- EHD proteins: key conductors of endocytic transport
- (2010) Naava Naslavsky et al. TRENDS IN CELL BIOLOGY
- The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER
- (2009) Helen R. Stagg et al. JOURNAL OF CELL BIOLOGY
- Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase
- (2009) Brian K. Sato et al. MOLECULAR CELL
- Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
- (2009) J. E. Carette et al. SCIENCE
- LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
- (2009) Noam Zelcer et al. SCIENCE
- Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508
- (2008) Daisuke Morito et al. MOLECULAR BIOLOGY OF THE CELL
- OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD
- (2008) John C. Christianson et al. NATURE CELL BIOLOGY
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