The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

(2013) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor

(2012) Vincenzo Sorrentino et al.   CURRENT OPINION IN LIPIDOLOGY

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia

(2012) Mohammad Mahdi Motazacker et al.   EUROPEAN HEART JOURNAL

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

(2012) Satish Pasula et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

(2012) Yan Wang et al.   JOURNAL OF LIPID RESEARCH

Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1

(2012) Yuan-Lin Kang et al.   MOLECULAR BIOLOGY OF THE CELL

Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan

(2012) Sara Sigismund et al.   PHYSIOLOGICAL REVIEWS

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

(2011) Vincenzo Sorrentino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists

(2011) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

(2010) Mark T Howes et al.   CURRENT OPINION IN CELL BIOLOGY

The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2

(2010) Cynthia Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter

(2010) Adèle Hannigan et al.   JOURNAL OF CLINICAL INVESTIGATION

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice

(2009) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

The Epidermal Growth Factor Homology Domain of the LDL Receptor Drives Lipoprotein Release through an Allosteric Mechanism Involving H190, H562, and H586

(2008) Zhenze Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus

(2008) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epsin 1 is Involved in Recruitment of Ubiquitinated EGF Receptors into Clathrin-Coated Pits

(2008) Maja Kazazic et al.   TRAFFIC