Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis

Direct Demonstration That Loop1 of Scap Binds to Loop7

(2016) Yinxin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic membrane protein topological switching upon changes in phospholipid environment

(2015) Heidi Vitrac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids and topological rules governing membrane protein assembly

(2013) Mikhail Bogdanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi

(2013) Yinxin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro reconstitution of lipid-dependent dual topology and postassembly topological switching of a membrane protein

(2013) Heidi Vitrac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis

(2011) Massoud Motamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

(2008) Michael S. Brown et al.   JOURNAL OF LIPID RESEARCH