Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity

(2018) Li-Hao Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

(2018) Yuyan Zhu et al.   JOURNAL OF LIPID RESEARCH

Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells

(2018) Hisataka Yamazaki et al.   Journal of Atherosclerosis and Thrombosis

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

(2017) Yong-Jian Wang et al.   NATURE CELL BIOLOGY

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

(2017) Reiner K. W. Mailer et al.   Scientific Reports

Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression

(2016) Li-Hao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential

(2015) Charlotte Spitz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

(2015) Ayaka Ito et al.   eLife

Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

(2014) Jessica S. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

(2014) K Yamanaka et al.   Cell Death & Disease

Acat1 Gene Ablation in Mice Increases Hematopoietic Progenitor Cell Proliferation in Bone Marrow and Causes Leukocytosis

(2013) Li-Hao Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth

(2013) Ming Lu et al.   Journal of Molecular Cell Biology

ACAT Inhibition Reduces the Progression of Preexisting, Advanced Atherosclerotic Mouse Lesions Without Plaque or Systemic Toxicity

(2012) James X. Rong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

The Role of Neutral Cholesterol Ester Hydrolysis in Macrophage Foam Cells

(2011) Motohiro Sekiya et al.   Journal of Atherosclerosis and Thrombosis

A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice

(2010) Yasunobu Yoshinaka et al.   ATHEROSCLEROSIS

The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages

(2010) Masaki Igarashi et al.   CIRCULATION RESEARCH

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

(2010) Xuewei Zhu et al.   JOURNAL OF LIPID RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular Imaging in Atherosclerosis, Thrombosis, and Vascular Inflammation

(2009) Robin P. Choudhury et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular mechanisms of the thrombotic complications of atherosclerosis

(2008) P. Libby   JOURNAL OF INTERNAL MEDICINE