Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
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Title
Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine
Authors
Keywords
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Journal
Chinese Medicine
Volume 14, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-11-07
DOI
10.1186/s13020-019-0270-9
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- Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways
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- Novel Multiple Apoptotic Mechanism of Shikonin in Human Glioma Cells
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- Gambogic Acid is a Novel Anti-cancer Agent that Inhibits Cell Proliferation, Angiogenesis and Metastasis
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- Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells
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- Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway
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- Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis
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- Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate
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- Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling
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- Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells
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- Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo
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- Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
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- Ursolic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis
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- Ursolic Acid from Oldenlandia diffusa Induces Apoptosis via Activation of Caspases and Phosphorylation of Glycogen Synthase Kinase 3 Beta in SK-OV-3 Ovarian Cancer Cells
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- Hydroxyl Radical (^|^middot;OH) Played a Pivotal Role in Oridonin-Induced Apoptosis and Autophagy in Human Epidermoid Carcinoma A431 Cells
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- Molecular Spectroscopy Evidence of Berberine Binding to DNA: Comparative Binding and Thermodynamic Profile of Intercalation
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- Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines
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- Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation
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- Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea
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- Cucurbitacin B Regulates Immature Myeloid Cell Differentiation and Enhances Antitumor Immunity in Patients with Lung Cancer
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- Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice
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- (5R)-5-hydroxytriptolide (LLDT-8), a novel immunosuppressant in clinical trials, exhibits potent antitumor activity via transcription inhibition
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- In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
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- Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells
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- Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine
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- Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride
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- 1187 Molecular Mechanism of Synergistic Anti-tumor Activity by the Combination of Natural Compounds Green Tea (-)Epigallocathetin-3-gallate (EGCG) and Resveratrol for Potential Chemoprevention in Head and Neck Cancer (HNC)
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- Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells
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- The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells
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- Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
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- Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
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- Curcumin targets fibroblast–tumor cell interactions in oral squamous cell carcinoma
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- Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors
- (2012) Xian-Huo Wang et al. Expert Opinion on Drug Metabolism & Toxicology
- Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model
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- The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress
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- Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro
- (2012) Guang-ju Zhao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells
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- The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer
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- Epigallocatechin-3-gallate potentiates curcumin’s ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis
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- Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells
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- Emodin Prevents Intrahepatic Fat Accumulation, Inflammation and Redox Status Imbalance During Diet-Induced Hepatosteatosis in Rats
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- Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells
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- The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma
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- Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis
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- Chronic treatment with ginsenoside Rg3 induces Akt-dependent senescence in human glioma cells
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- EGCG Inhibits Transforming Growth Factor-β-Mediated Epithelial-to-Mesenchymal Transition via the Inhibition of Smad2 and Erk1/2 Signaling Pathways in Nonsmall Cell Lung Cancer Cells
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- Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate
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- HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis
- (2012) Dan Liang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells
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- Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy
- (2012) Shengpeng Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells
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- The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells
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- Anti-viral effects of urosolic acid on guinea pig cytomegalovirus in vitro
- (2012) Jingjing Zhao et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Antioxidant, Antiproliferative, and Pro-Apoptotic Activities of a Saponin Extract Derived from the Roots of Panax notoginseng (Burk.) F.H. Chen
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- Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells
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- Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines
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- Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells
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- Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro
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- Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis
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- Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells
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- PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response
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- Therapeutic Efficacy of Silibinin on Human Neuroblastoma Cells: Akt and NF-κB Expressions May Play an Important Role in Silibinin-Induced Response
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- Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species
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- Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways
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- Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells
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- Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor
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- Curcumin Attenuates β-catenin Signaling in Prostate Cancer Cells through Activation of Protein Kinase D1
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- Tanshinone IIA Attenuates the Inflammatory Response and Apoptosis after Traumatic Injury of the Spinal Cord in Adult Rats
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- Antitumor Activity of Emodin against Pancreatic Cancer Depends on Its Dual Role: Promotion of Apoptosis and Suppression of Angiogenesis
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- Wogonin Induced Calreticulin/Annexin A1 Exposure Dictates the Immunogenicity of Cancer Cells in a PERK/AKT Dependent Manner
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- Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer
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- Emodin As an Effective Agent in Targeting Cancer Stem-Like Side Population Cells of Gallbladder Carcinoma
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- Berberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1
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- Protective effects of epigallocatechin gallate (EGCG) derivatives on azoxymethane-induced colonic carcinogenesis in mice
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- Hepatic arterial administration of ginsenoside Rg3 and transcatheter arterial embolization for the treatment of VX2 liver carcinomas
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- (-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells
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- Antioxidant and Cytotoxic Effects of Crude Extract, Fractions and 4-Nerolidylcathecol from Aerial Parts ofPothomorphe umbellataL. (Piperaceae)
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- Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity
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- Bioavailability Study of Berberine and the Enhancing Effects of TPGS on Intestinal Absorption in Rats
- (2011) Wei Chen et al. AAPS PHARMSCITECH
- Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells
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- Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
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- Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B
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- Study on the Autophagy of Prostate Cancer PC-3 Cells Induced by Oridonin
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- Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes
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- Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells
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- Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet
- (2011) Suowen Xu et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells
- (2011) Kyung Hun Kim et al. ARCHIVES OF PHARMACAL RESEARCH
- Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
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- Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells
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- β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis
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- Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells
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- Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway
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- Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells
- (2011) Y. Zhang et al. CELL BIOCHEMISTRY AND FUNCTION
- Proliferation-inhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro
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- Preparation and characterization of β-elemene-loaded microemulsion
- (2011) Chan-Juan Hu et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Curcumin enhanced adriamycin-induced human liver-derived Hepatoma G2 cell death through activation of mitochondria-mediated apoptosis and autophagy
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- Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9
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- GL-V9, a newly synthetic flavonoid derivative, induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells
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- Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition
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- Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways
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- Inhibitory effect of cepharanthine on dendritic cell activation and function
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- Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity
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- Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line
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- Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells
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- Development of (−)-epigallocatechin-3-gallate (EGCG)-loaded enteric microparticles with intestinal mucoadhesive property
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- EGCG Inhibits the Invasion of Highly Invasive CL1-5 Lung Cancer Cells through Suppressing MMP-2 Expression via JNK Signaling and Induces G2/M Arrest
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- Epigallocatechin-3 Gallate Inhibits Invasion, Epithelial−Mesenchymal Transition, and Tumor Growth in Oral Cancer Cells
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- Lipophilized Epigallocatechin Gallate (EGCG) Derivatives as Novel Antioxidants
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- Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway
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- Silibinin activated ROS–p38–NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells
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- Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells
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- Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus
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- Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice
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- β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells
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- Berberine Suppresses the TPA-Induced MMP-1 and MMP-9 Expressions Through the Inhibition of PKC-α in Breast Cancer Cells
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- Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
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- Chemopreventive and Chemotherapeutic Effects of Intravesical Silibinin against Bladder Cancer by Acting on Mitochondria
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- Effect of silibinin in human colorectal cancer cells: Targeting the activation of NF-κB signaling
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- Expression of β-catenin and cyclin D1 in epidermal stem cells of diabetic rats
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- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
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- microRNA expression profiling of nasopharyngeal carcinoma
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- Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines
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- Ginsenoside Rg3 inhibit hepatocellular carcinoma growthviaintrinsic apoptotic pathway
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- (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 бvia Stat3 in gastric cancer
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- Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells
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- Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
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- Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity
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- Silibinin-Induced Apoptosis in MCF7 and T47D Human Breast Carcinoma Cells Involves Caspase-8 Activation and Mitochondrial Pathway
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- Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
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- Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels
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- Proteomic and Functional Analyses Reveal the Potential Involvement of Endoplasmic Reticulum Stress and α-CP1 in the Anticancer Activities of Oridonin in HepG2 Cells
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- Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice
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- Artesunate inhibiting angiogenesis induced by human myeloma RPMI8226 cells
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- Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/Ã-catenin signaling
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- Antiangiogenic Potential of Three Triterpenic Acids in Human Liver Cancer Cells
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- Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: Studies in vitro and in vivo
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- Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line
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- Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells
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- Death receptor 5-mediated TNFR family signaling pathways modulate γ-humulene-induced apoptosis in human colorectal cancer HT29 cells
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- Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells
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