HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer

(2015) Radha Munagala et al.   CANCER LETTERS

Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway

(2015) Guobing Li et al.   PLoS One

Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab

(2014) E Zulato et al.   BRITISH JOURNAL OF CANCER

SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells

(2013) Si Chen et al.   CARCINOGENESIS

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression

(2013) Cheng-Chieh Chang et al.   PHYTOMEDICINE

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

The PI3K/AKT/mTOR Pathway as a Therapeutic Target in Endometrial Cancer

(2012) B. M. Slomovitz et al.   CLINICAL CANCER RESEARCH

Metformin impairs the growth of liver kinase B1-intact cervical cancer cells

(2012) Xuxian Xiao et al.   GYNECOLOGIC ONCOLOGY

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

(2012) Yong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression and prognostic significance of MAP4K4 in lung adenocarcinoma

(2012) Mei-Hua Qiu et al.   PATHOLOGY RESEARCH AND PRACTICE

A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment

(2012) Xiuxiu Li et al.   PLoS One

An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer

(2012) Fang Liu et al.   PLoS One

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

ShRNA-Targeted MAP4K4 Inhibits Hepatocellular Carcinoma Growth

(2011) A.-W. Liu et al.   CLINICAL CANCER RESEARCH

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

(2011) Yizhou Dong et al.   NATURAL PRODUCT REPORTS

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

A novel player in the p53-mediated autophagy: Sestrin2

(2010) Marcello D’Amelio et al.   CELL CYCLE

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway byNanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

(2010) Diana Cirstea et al.   MOLECULAR CANCER THERAPEUTICS

Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway

(2009) Todd Morgan et al.   CURRENT CANCER DRUG TARGETS

Map4k4Negatively Regulates Peroxisome Proliferator-activated Receptor (PPAR) γ Protein Translation by Suppressing the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Cultured Adipocytes

(2009) Kalyani V. P. Guntur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

(2009) Christine J Weydert et al.   Nature Protocols

Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

(2008) J. J. Liang et al.   CLINICAL CANCER RESEARCH

Specific Tyrosine Kinase Inhibitors Regulate Human Osteosarcoma Cells In vitro

(2008) Patrick J. Messerschmitt et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest

(2008) Lingli Zhou et al.   LIFE SCIENCES

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY