The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

(2010) Feng-Hou Gao et al.   BMC CANCER

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

(2010) Ning Kang et al.   CANCER LETTERS

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

(2010) Carolyn Algire et al.   ENDOCRINE-RELATED CANCER

Metabolism and proliferation share common regulatory pathways in cancer cells

(2010) V Fritz et al.   ONCOGENE

Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells

(2010) Hui Wang et al.   PHYTOMEDICINE

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

(2009) Roger H.F. Wong et al.   CELL

Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention

(2009) Kathleen E. Kearney et al.   INTERNATIONAL JOURNAL OF CANCER

Sp1 coordinately regulatesde novolipogenesis and proliferation in cancer cells

(2009) Suying Lu et al.   INTERNATIONAL JOURNAL OF CANCER

CNGA2 Contributes to ATP-Induced Noncapacitative Ca2+ Influx in Vascular Endothelial Cells

(2009) Hiu-Yee Kwan et al.   JOURNAL OF VASCULAR RESEARCH

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH

Control of Cell Growth and Survival by Enzymes of the Fatty Acid Synthesis Pathway in HCT-116 Colon Cancer Cells

(2008) Y. Zhan et al.   CLINICAL CANCER RESEARCH

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics