Artemisinin induces A549 cell apoptosis dominantly via a reactive oxygen species-mediated amplification activation loop among caspase-9, -8 and -3

Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells

(2012) Fenglian Xiao et al.   APOPTOSIS

Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells

(2012) Weiwei Zhang et al.   CELLULAR SIGNALLING

Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells

(2012) Chenjuan Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells

(2010) Ying-Ying Lu et al.   FEBS LETTERS

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell analysis of dihydroartemisinin–induced apoptosis through reactive oxygen species–mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques

(2010) Ying-Ying Lu et al.   JOURNAL OF BIOMEDICAL OPTICS

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop

(2010) Radharaman Ray et al.   TOXICOLOGY

Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells

(2009) Mahmoud Youns et al.   BIOCHEMICAL PHARMACOLOGY

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

(2009) Martin Michaelis et al.   BIOCHEMICAL PHARMACOLOGY

Autocrine amplification loop in statin-induced apoptosis of human melanoma cells

(2009) C Minichsdorfer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

(2009) H Düssmann et al.   CELL DEATH AND DIFFERENTIATION

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

(2009) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Cleavage of Bid by Executioner Caspases Mediates Feed Forward Amplification of Mitochondrial Outer Membrane Permeabilization during Genotoxic Stress-induced Apoptosis in Jurkat Cells

(2009) Shary N. Shelton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etoposide Induces Protein Kinase C - and Caspase-3-Dependent Apoptosis in Neuroblastoma Cancer Cells

(2009) T. W. Day et al.   MOLECULAR PHARMACOLOGY

Transferrin receptor-dependent cytotoxicity of artemisinin–transferrin conjugates on prostate cancer cells and induction of apoptosis

(2008) Ikuhiko Nakase et al.   CANCER LETTERS

Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells

(2008) S. N. Sundar et al.   CARCINOGENESIS

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH

Fas/CD95-Mediated Apoptosis of Type II Cells Is Blocked by Toxoplasma gondii Primarily via Interference with the Mitochondrial Amplification Loop

(2008) D. Hippe et al.   INFECTION AND IMMUNITY

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression

(2008) Jamin A. Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy

(2008) Tao Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE