Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

(2016) Gagan Deep et al.   Scientific Reports

Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings

(2015) Avelino Fraga et al.   Clinical Genitourinary Cancer

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake in Prostate Cancer Mouse Xenografts

(2015) Isabel R. Schlaepfer et al.   MOLECULAR IMAGING AND BIOLOGY

HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase

(2015) Jayasri Nanduri et al.   PLoS One

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

(2015) Dhanya K. Nambiar et al.   Oncotarget

The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer

(2014) H B Ragnum et al.   BRITISH JOURNAL OF CANCER

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

The effects of nonspecific HIF1αinhibitors on development of castrate resistance and metastases in prostate cancer

(2014) Weranja K. B. Ranasinghe et al.   Cancer Medicine

The fat side of prostate cancer

(2013) Giorgia Zadra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury

(2013) Lauren Frey et al.   NEUROLOGICAL RESEARCH

The Role of Hypoxia-Inducible Factor 1α in Determining the Properties of Castrate-Resistant Prostate Cancers

(2013) Weranja K. B. Ranasinghe et al.   PLoS One

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study

(2012) K. Raina et al.   Cancer Prevention Research

Tumor Hypoxia Predicts Biochemical Failure following Radiotherapy for Clinically Localized Prostate Cancer

(2012) M. Milosevic et al.   CLINICAL CANCER RESEARCH

Angiopreventive Efficacy of Pure Flavonolignans from Milk Thistle Extract against Prostate Cancer: Targeting VEGF-VEGFR Signaling

(2012) Gagan Deep et al.   PLoS One

Lipids and prostate cancer

(2012) Janel Suburu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)

(2012) Puspa R. Pandey et al.   Recent Patents on Anti-Cancer Drug Discovery

Role of E-cadherin in Antimigratory and Antiinvasive Efficacy of Silibinin in Prostate Cancer Cells

(2011) G. Deep et al.   Cancer Prevention Research

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

(2011) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment

(2011) Elizabeth A. Platz et al.   Cancer Discovery

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Metabolic alterations and targeted therapies in prostate cancer

(2010) Richard Flavin et al.   JOURNAL OF PATHOLOGY

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment

(2010) Takakazu Mitani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Diffusion MR Imaging for Monitoring of Treatment Response

(2010) Anwar R. Padhani et al.   Magnetic Resonance Imaging Clinics of North America

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

(2010) E. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silibinin inhibits expression of HIF-1α through suppression of protein translation in prostate cancer cells

(2009) Hui-Jung Jung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The relevance of a hypoxic tumour microenvironment in prostate cancer

(2009) Grant D. Stewart et al.   BJU INTERNATIONAL

Silibinin Suppresses Growth of Human Prostate Carcinoma PC-3 Orthotopic Xenograft via Activation of Extracellular Signal-Regulated Kinase 1/2 and Inhibition of Signal Transducers and Activators of Transcription Signaling

(2009) R. P. Singh et al.   CLINICAL CANCER RESEARCH

Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model

(2008) K. Raina et al.   CANCER RESEARCH

Silibinin Inhibits Established Prostate Tumor Growth, Progression, Invasion, and Metastasis and Suppresses Tumor Angiogenesis and Epithelial-Mesenchymal Transition in Transgenic Adenocarcinoma of the Mouse Prostate Model Mice

(2008) R. P. Singh et al.   CLINICAL CANCER RESEARCH

Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study

(2008) Roy Vergis et al.   LANCET ONCOLOGY

Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

(2008) P García-Maceira et al.   ONCOGENE