Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
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Title
Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
Authors
Keywords
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Journal
ACTA PHARMACOLOGICA SINICA
Volume 39, Issue 5, Pages 802-824
Publisher
Springer Nature
Online
2018-04-27
DOI
10.1038/aps.2017.193
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- Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation
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- Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B
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- Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo
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- Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS
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- Tanshinone IIA Inhibits Angiotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts
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- Tanshinone IIA–Induced Attenuation of Lung Injury in Endotoxemic Mice Is Associated with Reduction of Hypoxia-Inducible Factor 1α Expression
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- Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet
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- Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion
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- Cardiovascular actions and therapeutic potential of tanshinone IIA
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- Protocatechuic Aldehyde Protects against Experimental Sepsis In Vitro and In Vivo
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- Tanshinone IIA Attenuates Seawater Aspiration-Induced Lung Injury by Inhibiting Macrophage Migration Inhibitory Factor
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- Cardiovascular Protection with Danshensu in Spontaneously Hypertensive Rats
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- Anti-angiogenic effect of Tanshinone IIA involves inhibition of matrix invasion and modification of MMP-2/TIMP-2 secretion in vascular endothelial cells
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- Tanshinone IIA Inhibits miR-1 Expression through p38 MAPK Signal Pathway in Post-infarction Rat Cardiomyocytes
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- Blocking effect of salvianolic acid a on calcium channels in isolated rat ventricular myocytes
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- Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide
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- Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells
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- Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress
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- Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ
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- Cryptotanshinone inhibits LPS-induced proinflammatory mediators via TLR4 and TAK1 signaling pathway
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- Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials
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- Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats
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- Salvianolic Acid A Demonstrates Cardioprotective Effects in Rat Hearts and Cardiomyocytes After Ischemia/Reperfusion Injury
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- Direct Vasorelaxation by a Novel Phytoestrogen Tanshinone IIA Is Mediated by Nongenomic Action of Estrogen Receptor Through Endothelial Nitric Oxide Synthase Activation and Calcium Mobilization
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- Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways
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- Using neural networks to determine the contribution of danshensu to its multiple cardiovascular activities in acute myocardial infarction rats
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- Cardioprotective effect of water and ethanol extract of Salvia miltiorrhiza in an experimental model of myocardial infarction
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- Progress and challenges in translating the biology of atherosclerosis
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- Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y Cells
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- Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from Salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats
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- Retracted: Protective Effects of Rutin on Rat Glomerular Mesangial Cells Cultured in High Glucose Conditions
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- Cryptotanshinone AttenuatesIn VitrooxLDL-Induced Pre-Lesional Atherosclerotic Events
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- Differential Proteomic Analysis of Platelets Suggested Possible Signal Cascades Network in Platelets Treated with Salvianolic Acid B
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- Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network
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- Salvianolic acid B inhibits SDF-1α-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor
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- Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia
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- Salvianolic acid B inhibits autophagy and protects starving cardiac myocytes
- (2010) Xiao Han et al. ACTA PHARMACOLOGICA SINICA
- Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes
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- Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons
- (2010) Zhengrong Mei et al. BRAIN RESEARCH
- Tanshinone IIA attenuates atherosclerosis in ApoE−/− mice through down-regulation of scavenger receptor expression
- (2010) Fu-Tian Tang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-κB and MAPK Signaling Pathways
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- Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway
- (2010) Hong-Jye Hong et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway
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- Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate
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- Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits
- (2010) Tung-Lin Yang et al. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
- Salvianolic acid A inhibits platelet activation and arterial thrombosis via inhibition of phosphoinositide 3-kinase
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- Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension
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- Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model
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- Antiplatelet and antithrombotic activities of salvianolic acid A
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- Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling
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- Inhibitory effects of lithospermic acid on proliferation and migration of rat vascular smooth muscle cells
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- Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates
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- Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1
- (2009) Hongli Shan et al. BRITISH JOURNAL OF PHARMACOLOGY
- Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats
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- Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo
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- Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats
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- Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro
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- Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo
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- A Preparation of Herbal Medicine Salvia miltiorrhiza Reduces Expression of Intercellular Adhesion Molecule-1 and Development of Atherosclerosis in Apolipoprotein E-Deficient Mice
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- Proliferative inhibition of danxiongfang and its active ingredients on rat vascular smooth muscle cell and protective effect on the VSMC damage induced by hydrogen peroxide
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- Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current
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- The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS
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- Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro
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- Molecular targets and regulators of cardiac hypertrophy
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- Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression
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- Cryptotanshinone, an Acetylcholinesterase Inhibitor fromSalvia miltiorrhiza, Ameliorates Scopolamine-Induced Amnesia in Morris Water Maze Task
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- Interaction of Salvianolic Acids and Notoginsengnosides in Inhibition of ADP-Induced Platelet Aggregation
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- 15,16-Dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization
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- Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge
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- Down-Regulation of CD40 Gene Expression and Inhibition of Apoptosis with Danshensu in Endothelial Cells
- (2008) Guang-De Yang et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: New anti-angina mechanism implication
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- Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction
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- Activation of high conductance Ca2+-activated K+ channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells
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- Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (IKs) potassium channels
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- Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress
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- Sodium Tanshinone IIA Sulfonate Protects Cardiomyocytes Against Oxidative Stress-mediated Apoptosis Through Inhibiting JNK Activation
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- Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels
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- Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase
- (2008) Yu-I Li et al. LIFE SCIENCES
- Tackling heart failure in the twenty-first century
- (2008) James O. Mudd et al. NATURE
- Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis
- (2008) Jie Gao et al. Translational Research
- Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
- (2008) Fangyan Zhang et al. EXPERIMENTAL BRAIN RESEARCH
- Effects of tanshinone VI on phosphorylation of ERK and Akt in isolated cardiomyocytes and cardiac fibroblasts
- (2007) Toru Arino et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Tanshinone IIA fromSalvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway
- (2007) Un-Ho Jin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit
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