The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells

(2018) Tiziana Notarangelo et al.   CANCER LETTERS

Patient Derived Xenografts as Models for Head and Neck Cancer

(2018) Nitschinsk Km et al.   CANCER LETTERS

Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells

(2018) Xin Xu et al.   CANCER SCIENCE

Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3–COX2-dependent pathway

(2018) Ang Li et al.   ONCOGENE

Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries

(2018) Martin C. S. Wong et al.   Scientific Reports

Understanding the tumour microenvironment communication network from a NOS2/COX2 perspective

(2018) Debashree Basudhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin derivative L6H4 inhibits proliferation and invasion of gastric cancer cell line BGC-823

(2018) Jianfeng Mu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The tyrosine phosphorylated pro-survival form of Fas intensifies the EGF-induced signal in colorectal cancer cells through the nuclear EGFR/STAT3-mediated pathway

(2018) Ngoc Ly Ta et al.   Scientific Reports

Dose-escalated radiotherapy improved survival for esophageal cancer patients with a clinical complete response after standard-dose radiotherapy with concurrent chemotherapy

(2018) Wei Zhang et al.   Cancer Management and Research

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

(2018) Loukik Arora et al.   Cancers

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

(2017) Peter Jones et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma

(2017) Gopinath M Sundaram et al.   TUMOR BIOLOGY

Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways

(2016) W. Lim et al.   BIOLOGY OF REPRODUCTION

New perspectives on role of tumor microenvironment in progression of cutaneous squamous cell carcinoma

(2016) Liisa Nissinen et al.   CELL AND TISSUE RESEARCH

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Natural Compounds Targeting STAT3 Mediated Inflammation

(2016) Edwin E. Morales et al.   EUROPEAN UROLOGY

CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer

(2016) Chunyan Zhang et al.   IMMUNITY

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Curcumin inhibits invasive capabilities through epithelial mesenchymal transition in breast cancer cell lines

(2016) Marcela Gallardo et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1

(2016) Xin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both

(2016) S Koschmieder et al.   LEUKEMIA

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence

(2016) N Garg et al.   ONCOGENE

Cyclooxygenase 2 inhibition in patients with non-small cell lung cancer: Is this still a valid target for therapy?

(2015) Shirish M. Gadgeel   CANCER

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway

(2015) Hao Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+breast cancers

(2015) Ruth Rodriguez-Barrueco et al.   GENES & DEVELOPMENT

Chronic inflammation and the development of malignancy in the GI tract

(2015) Stefan Fichtner-Feigl et al.   TRENDS IN IMMUNOLOGY

STAT3 regulated ARF expression suppresses prostate cancer metastasis

(2015) Jan Pencik et al.   Nature Communications

JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response

(2015) M. Kleppe et al.   Cancer Discovery

SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway

(2015) Kunkun Han et al.   Scientific Reports

COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells

(2015) Ze-Lei Li et al.   OncoImmunology

A microRNA 221– and 222–Mediated Feedback Loop Maintains Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells

(2014) Sanhong Liu et al.   GASTROENTEROLOGY

Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues

(2014) Guodong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Natural Pesticide Dihydrorotenone Arrests Human Plasma Cancer Cells at the G0/G1 Phase of the Cell Cycle

(2014) Xin Xu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization

(2014) Kunkun Han et al.   Journal of Hematology & Oncology

Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts

(2014) Shahar Lev-Ari et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits

(2013) SEYUNG S. CHUNG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP

(2013) Xin Huang et al.   JOURNAL OF CLINICAL ONCOLOGY

Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF- B signaling pathway in vitro and in vivo

(2012) F. Tian et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Suppression of tumor invasion and migration in breast cancer cells following delivery of siRNA against Stat3 with the antimicrobial peptide PR39

(2012) WENXIA TIAN et al.   ONCOLOGY REPORTS

Inflammation and Cancer: A Comparative View

(2011) Wallace B. Morrison   JOURNAL OF VETERINARY INTERNAL MEDICINE

A small interfering RNA targeting NF-κB p65 alone or combined with 5-FU inhibits growth of esophageal squamous cell carcinoma in nude mice

(2011) Fang Tian et al.   PATHOLOGY RESEARCH AND PRACTICE