Computational prediction and experimental validation of low-affinity target of triptolide and its analogues

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

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Asp120Asn mutation impairs the catalytic activity of NDM-1 metallo-β-lactamase: experimental and computational study

(2014) Jiao Chen et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera

(2013) Hyun Ah Jung et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis

(2013) Yi Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Triptolide on Malignant Peripheral Nerve Sheath Tumours In Vitro and In Vivo

(2013) W Wang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Triptolide induces apoptosis in endometrial cancer via a p53-independent mitochondrial pathway

(2013) XIAO-FEI WANG et al.   Molecular Medicine Reports

How to conduct and interpret ITC experiments accurately for cyclodextrin–guest interactions

(2012) Kawthar Bouchemal et al.   DRUG DISCOVERY TODAY

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin

(2012) Hongxi Zhao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation

(2012) Hu Xiaowen et al.   MOLECULAR BIOLOGY REPORTS

Triptolide Inhibits MDM2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p53-Independent Pathway

(2012) M. Huang et al.   MOLECULAR CANCER THERAPEUTICS

Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21

(2012) Juanjuan Liu et al.   PHYTOMEDICINE

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

(2011) Janet Newman et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase—9 expression

(2011) Shengbo Yang et al.   Asian Pacific Journal of Tropical Medicine

Nuclear receptors as drug targets for metabolic disease

(2010) Ira G. Schulman   ADVANCED DRUG DELIVERY REVIEWS

Nuclear receptor coregulators as a new paradigm for therapeutic targeting

(2010) Elaine Y. Hsia et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular basis for gene-specific transactivation by nuclear receptors

(2010) Mads M. Aagaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins

(2009) Jennifer A. Maynard et al.   Biotechnology Journal

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

(2009) Pablo Kizelsztein et al.   JOURNAL OF NEUROIMMUNOLOGY

Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine Receptors

(2009) Sara M. Johnson et al.   JOURNAL OF SURGICAL RESEARCH

Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells

(2009) Bin Shu et al.   TOXICOLOGY IN VITRO

Nuclear receptors and coregulators in inflammation and cancer

(2008) Jason S. Lee et al.   CANCER LETTERS

Nuclear receptor drug discovery

(2008) Taosheng Chen   CURRENT OPINION IN CHEMICAL BIOLOGY

Flexible ligand docking to multiple receptor conformations: a practical alternative

(2008) Maxim Totrov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY