Combined Use of Zoledronic Acid Augments Ursolic Acid-Induced Apoptosis in Human Osteosarcoma Cells through Enhanced Oxidative Stress and Autophagy

Ursolic Acid Triggers Apoptosis in Human Osteosarcoma Cells via Caspase Activation and the ERK1/2 MAPK Pathway

(2016) Chia-Chieh Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ursolic acid (UA): A metabolite with promising therapeutic potential

(2016) Dharambir Kashyap et al.   LIFE SCIENCES

The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways

(2016) Wan-Ling Chuang et al.   MOLECULES

Mitochondrial Redox Signaling and Tumor Progression

(2016) Yuxin Chen et al.   Cancers

Reactive Oxygen Species in Cancer: A Dance with the Devil

(2015) Paul T. Schumacker   CANCER CELL

Ursolic acid inhibits the proliferation of human ovarian cancer stem-like cells through epithelial-mesenchymal transition

(2015) JIE ZHANG et al.   ONCOLOGY REPORTS

Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line

(2015) Yang Yang et al.   PLoS One

Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

(2015) Jian-Shuang Li et al.   Food & Function

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

(2015) Liping Xiang et al.   Oncotarget

Nitric oxide-mediated cytotoxic effect induced by zoledronic acid treatment on human gingival fibroblasts

(2014) Marianna De Colli et al.   Clinical Oral Investigations

Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation

(2014) Joo-Hyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

(2014) Xi-Yuan Ge et al.   PLoS One

Zoledronic acid induces apoptosis and autophagy in cervical cancer cells

(2014) I-Te Wang et al.   TUMOR BIOLOGY

Ursolic acid inhibits the invasive phenotype of SNU-484 human gastric cancer cells

(2014) EUN-SOOK KIM et al.   Oncology Letters

Ursolic acid inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor

(2013) Sarita Saraswati et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cisplatin in combination with zoledronic acid: A synergistic effect in triple-negative breast cancer cell lines

(2013) TONI IBRAHIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways

(2013) F Bruzzese et al.   Cell Death & Disease

Zoledronic acid significantly enhances radiation-induced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling

(2012) KAZUTAKA KOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Bisphosphonates regulate cell proliferation, apoptosis and pro-osteoclastic expression in MG-63 human osteosarcoma cells

(2012) JUN CHANG et al.   Oncology Letters

Zoledronic Acid Induces Autophagic Cell Death in Human Prostate Cancer Cells

(2011) Ji-Fan Lin et al.   JOURNAL OF UROLOGY

Zoledronic Acid Potentiates mTOR Inhibition and Abolishes the Resistance of Osteosarcoma Cells to RAD001 (Everolimus): Pivotal Role of the Prenylation Process

(2010) G. Moriceau et al.   CANCER RESEARCH

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

(2009) Angela C. Hirbe et al.   BONE

Zoledronic Acid Inhibits Both the Osteolytic and Osteoblastic Components of Osteosarcoma Lesions in a Mouse Model

(2009) A. Labrinidis et al.   CLINICAL CANCER RESEARCH