Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinoma

Targeting the MIR34C-5p-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin

(2016) Yaran Wu et al.   Autophagy

Inhibition of autophagy promotes apoptosis and enhances anticancer efficacy of adriamycin via augmented ROS generation in prostate cancer cells

(2016) Jizhong Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway

(2016) Shijie Cao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer

(2016) V. K. Kozyreva et al.   MOLECULAR CANCER THERAPEUTICS

Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis

(2016) Hao Wang et al.   Scientific Reports

Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells

(2016) Lu Chen et al.   Scientific Reports

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

(2016) Ran Wang et al.   Scientific Reports

MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells

(2015) Honghe Zhang et al.   CANCER LETTERS

NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK

(2015) Fangjin Lu et al.   CANCER SCIENCE

Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells

(2015) NING KANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

YM155 potently triggers cell death in breast cancer cells through an autophagy-NF-kB network

(2015) Eloïse Véquaud et al.   Oncotarget

Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway

(2014) Ting Li et al.   BMC CANCER

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Mimulone-Induced Autophagy through p53-Mediated AMPK/mTOR Pathway Increases Caspase-Mediated Apoptotic Cell Death in A549 Human Lung Cancer Cells

(2014) Hyun-Kyu An et al.   PLoS One

Autophagic cell death induced by resveratrol depends on the Ca2+/AMPK/mTOR pathway in A549 cells

(2013) Jun Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells. A soluble parthenolide analogue inhibits tumour growth and metastasis in a xenograft model of breast cancer

(2013) A D'Anneo et al.   Cell Death & Disease

The roles of BECN1 and autophagy in cancer are context dependent

(2012) Chang Gong et al.   Autophagy

Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway

(2012) Mireia Niso-Santano et al.   Autophagy

Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells

(2012) Katarina Arsikin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells

(2012) Xiang Li et al.   International Journal of Biological Sciences

Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1

(2011) Rong Zeng et al.   ACTA PHARMACOLOGICA SINICA

The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion

(2011) Rong Zeng et al.   ANNALS OF HEMATOLOGY

Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells

(2011) Linghe Zang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

(2011) Kaipeng Jing et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

The multiple roles of autophagy in cancer

(2011) M. T. Rosenfeldt et al.   CARCINOGENESIS

LKB1/AMPK/mTOR signaling pathway in hematological malignancies: From metabolism to cancer cell biology

(2011) Alexa S. Green et al.   CELL CYCLE

Autophagy and cytokines

(2011) James Harris   CYTOKINE

Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

(2011) Chun-yang Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heat shock protein 90–mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells

(2011) Qian Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis

(2011) Y. Cheng et al.   MOLECULAR CANCER THERAPEUTICS

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Impact of Autophagy on Chemotherapy and Radiotherapy Mediated Tumor Cytotoxicity: ?To Live or not to Live?

(2011) Xuehuo Zeng et al.   Frontiers in Oncology

Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways

(2010) Ning Kang et al.   CANCER LETTERS

Induction of G2/M Phase Arrest and Apoptosis by Oridonin in Human Laryngeal Carcinoma Cells

(2010) Ning Kang et al.   JOURNAL OF NATURAL PRODUCTS

Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression

(2009) Xi Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Synergistic Growth Inhibition of Squamous Cell Carcinoma of the Head and Neck by Erlotinib and Epigallocatechin-3-Gallate: The Role of p53-Dependent Inhibition of Nuclear Factor- B

(2009) A. R. M. R. Amin et al.   Cancer Prevention Research

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: A protective mechanism against apoptosis

(2008) Yahong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the epidermal growth factor receptor in metastatic colorectal cancer

(2007) Kimmie Ng et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY