Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

(2016) Youyou Tu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target identification of natural and traditional medicines with quantitative chemical proteomics approaches

(2016) Jigang Wang et al.   PHARMACOLOGY & THERAPEUTICS

Artemisinin, a miracle of traditional Chinese medicine

(2015) Ling Yi Kong et al.   NATURAL PRODUCT REPORTS

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Mitochondria-Targeted Cancer Therapy Using a Light-Up Probe with Aggregation-Induced-Emission Characteristics

(2014) Qinglian Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

(2014) Nai-Di Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malaria: a molecular marker of artemisinin resistance

(2014) Nicholas J White   LANCET

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

(2014) Jigang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Treatment of Malaria — A Continuing Challenge

(2014) Brian Greenwood   NEW ENGLAND JOURNAL OF MEDICINE

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

(2013) Thomas Antoine et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

(2010) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

(2010) Xavier C. Ding et al.   TRENDS IN PARASITOLOGY

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Small mitochondria-targeting molecules as anti-cancer agents

(2009) Feng Wang et al.   MOLECULAR ASPECTS OF MEDICINE

Artemisinins: their growing importance in medicine

(2008) Sanjeev Krishna et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Iron chelators can protect against oxidative stress through ferryl heme reduction

(2007) Brandon J. Reeder et al.   FREE RADICAL BIOLOGY AND MEDICINE