Structure, properties, and biological relevance of the DNA and RNA G-quadruplexes: Overview 50 years after their discovery

G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells

(2016) Daiki Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA G-Quadruplex Invasion and Translation Inhibition by Antisense γ-Peptide Nucleic Acid Oligomers

(2016) Stanley N. Oyaghire et al.   BIOCHEMISTRY

Mutually Exclusive Formation of G-Quadruplex and i-Motif Is a General Phenomenon Governed by Steric Hindrance in Duplex DNA

(2016) Yunxi Cui et al.   BIOCHEMISTRY

Reevaluation of the stability of G-quadruplex structures under crowding conditions

(2016) Jun Zhou et al.   BIOCHIMIE

Stable Domain Assembly of a Monomolecular DNA Quadruplex: Implications for DNA-Based Nanoswitches

(2016) Besik Kankia et al.   BIOPHYSICAL JOURNAL

Enantioselective targeting left-handed Z-G-quadruplex

(2016) Andong Zhao et al.   CHEMICAL COMMUNICATIONS

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

(2016) Barira Islam et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription

(2016) Buket Onel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches

(2016) Eric Largy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium

(2016) Carole Saintomé et al.   NUCLEIC ACIDS RESEARCH

Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA

(2016) Mateusz Kogut et al.   NUCLEIC ACIDS RESEARCH

G-register exchange dynamics in guanine quadruplexes

(2016) Robert W. Harkness et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes as novel cis-elements controlling transcription during embryonic development

(2016) Aldana P. David et al.   NUCLEIC ACIDS RESEARCH

Re-evaluation of G-quadruplex propensity with G4Hunter

(2016) Amina Bedrat et al.   NUCLEIC ACIDS RESEARCH

A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes

(2016) Zi-Fu Wang et al.   NUCLEIC ACIDS RESEARCH

Downregulation of the WT1 gene expression via TMPyP4 stabilization of promoter G-quadruplexes in leukemia cells

(2016) Saeedeh Ghazaey Zidanloo et al.   TUMOR BIOLOGY

Involvement of Long-Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G-Quadruplex

(2015) Irene Bessi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted Detection of G-Quadruplexes in Cellular RNAs

(2015) Chun Kit Kwok et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

K+-responsive off-to-on switching of hammerhead ribozyme through dual G-quadruplex formation requiring no heating and cooling treatment

(2015) Yudai Yamaoki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A stable RNA G-quadruplex within the 5′-UTR ofArabidopsis thaliana ATRmRNA inhibits translation

(2015) Chun Kit Kwok et al.   BIOCHEMICAL JOURNAL

G-Quadruplex-Enabling Sequence within the Human Tyrosine Hydroxylase Promoter Differentially Regulates Transcription

(2015) Mohamed M. Farhath et al.   BIOCHEMISTRY

Effects of Salt on the Stability of a G-Quadruplex from the Human c-MYC Promoter

(2015) Byul G. Kim et al.   BIOCHEMISTRY

An Independently Folding RNA G-Quadruplex Domain Directly Recruits the 40S Ribosomal Subunit

(2015) Debmalya Bhattacharyya et al.   BIOCHEMISTRY

Evidence for the Kinetic Partitioning of Polymerase Activity on G-Quadruplex DNA

(2015) Sarah Eddy et al.   BIOCHEMISTRY

Conformations of Human Telomeric G-Quadruplex Studied Using a Nucleotide-Independent Nitroxide Label

(2015) Xiaojun Zhang et al.   BIOCHEMISTRY

Effect of Interior Loop Length on the Thermal Stability and pKa of i-Motif DNA

(2015) Samantha M. Reilly et al.   BIOCHEMISTRY

Parallel G-quadruplexes formed by guanine-rich microsatellite repeats inhibit human topoisomerase I

(2015) A. M. Ogloblina et al.   BIOCHEMISTRY-MOSCOW

Kinetics of quadruplex to duplex conversion

(2015) Oscar Mendoza et al.   BIOCHIMIE

Diverse effects of naturally occurring base lesions on the structure and stability of the human telomere DNA quadruplex

(2015) Helena Konvalinová et al.   BIOCHIMIE

Understanding the stability of DNA G-quadruplex units in long human telomeric strands

(2015) Anthony Bugaut et al.   BIOCHIMIE

Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1

(2015) Mathieu Métifiot et al.   BIOCHIMIE

Assessment of selectivity of G-quadruplex ligands via an optimised FRET melting assay

(2015) Aurore De Rache et al.   BIOCHIMIE

Emerging role of RNA•DNA hybrids inC9orf72-linked neurodegeneration

(2015) Jiou Wang et al.   CELL CYCLE

G-quadruplex ligands exhibit differential G-tetrad selectivity

(2015) D. D. Le et al.   CHEMICAL COMMUNICATIONS

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(iii) complex

(2015) Sheng Lin et al.   CHEMICAL COMMUNICATIONS

Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA

(2015) Jun Gao et al.   CHEMICAL COMMUNICATIONS

Red emissive AIE luminogens with high hole-transporting properties for efficient non-doped OLEDs

(2015) Wei Qin et al.   CHEMICAL COMMUNICATIONS

Co-self-assembled nanoaggregates of BODIPY amphiphiles for dual colour imaging of live cells

(2015) Gang Fan et al.   CHEMICAL COMMUNICATIONS

A Potassium Ion-Dependent RNA Structural Switch Regulates Human Pre-miRNA 92b Maturation

(2015) Gayan Mirihana Arachchilage et al.   CHEMISTRY & BIOLOGY

Contributions of the specialised DNA polymerases to replication of structured DNA

(2015) Caroline M. Wickramasinghe et al.   DNA REPAIR

Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites

(2015) A. Piazza et al.   EMBO JOURNAL

A family of DNA aptamers with varied duplex region length that forms complexes with thrombin and prothrombin

(2015) V.A. Spiridonova et al.   FEBS LETTERS

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

(2015) Roberto Simone et al.   FEBS LETTERS

Characterizing and controlling intrinsic biases of lambda exonuclease in nascent strand sequencing reveals phasing between nucleosomes and G-quadruplex motifs around a subset of human replication origins

(2015) Michael S. Foulk et al.   GENOME RESEARCH

G-quadruplexes Significantly Stimulate Pif1 Helicase-catalyzed Duplex DNA Unwinding

(2015) Xiao-Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

(2015) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All-Atomic Simulations on Human Telomeric G-Quadruplex DNA Binding with Thioflavin T

(2015) Di Luo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Visualization of RNA-Quadruplexes in Live Cells

(2015) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stability and Kinetics of c-MYC Promoter G-Quadruplexes Studied by Single-Molecule Manipulation

(2015) Huijuan You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents

(2015) Domenica Musumeci et al.   MOLECULES

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+solutions by single molecule FRET microscopy

(2015) Sofie L. Noer et al.   NUCLEIC ACIDS RESEARCH

Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription

(2015) Elena Tosoni et al.   NUCLEIC ACIDS RESEARCH

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

(2015) O. Mendoza et al.   NUCLEIC ACIDS RESEARCH

Role of the central cations in the mechanical unfolding of DNA and RNA G-quadruplexes

(2015) Ana Elisa Bergues-Pupo et al.   NUCLEIC ACIDS RESEARCH

Guanine quadruplex structures localize to heterochromatin

(2015) Roland F. Hoffmann et al.   NUCLEIC ACIDS RESEARCH

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding

(2015) Sangeetha Selvam et al.   NUCLEIC ACIDS RESEARCH

KRASpromoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units

(2015) Peter Podbevšek et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triad·water complex and implication for small-molecule binding

(2015) Brahim Heddi et al.   NUCLEIC ACIDS RESEARCH

Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo

(2015) Kyotaro Hirashima et al.   NUCLEIC ACIDS RESEARCH

Extended molecular dynamics of ac-kitpromoter quadruplex

(2015) Barira Islam et al.   NUCLEIC ACIDS RESEARCH

Conformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes

(2015) Arun A. Tanpure et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex formation in double strand DNA probed by NMM and CV fluorescence

(2015) Alex Kreig et al.   NUCLEIC ACIDS RESEARCH

Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study

(2015) K. W. Lim et al.   NUCLEIC ACIDS RESEARCH

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase

(2015) Michael C. Chen et al.   NUCLEIC ACIDS RESEARCH

BLM unfolds G-quadruplexes in different structural environments through different mechanisms

(2015) Wen-Qiang Wu et al.   NUCLEIC ACIDS RESEARCH

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

(2015) Pasquale Zizza et al.   NUCLEIC ACIDS RESEARCH

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2′-deoxyuridine on telomeric G-quadruplex structures

(2015) Antonella Virgilio et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex

(2015) Brahim Heddi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a left-handed DNA G-quadruplex

(2015) Wan Jun Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

“Nano-oddities”: Unusual Nucleic Acid Assemblies for DNA-Based Nanostructures and Nanodevices

(2014) Liliya A. Yatsunyk et al.   ACCOUNTS OF CHEMICAL RESEARCH

Topology Specific Stabilization of Promoter over Telomeric G-Quadruplex DNAs by Bisbenzimidazole Carboxamide Derivatives

(2014) V. Dhamodharan et al.   ACS Chemical Biology

Direct and Single-Molecule Visualization of the Solution-State Structures of G-Hairpin and G-Triplex Intermediates

(2014) Arivazhagan Rajendran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)

(2014) Zoë A.E. Waller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic Modification, Dehydration, and Molecular Crowding Effects on the Thermodynamics of i-Motif Structure Formation from C-Rich DNA

(2014) Yogini P. Bhavsar-Jog et al.   BIOCHEMISTRY

Rationally Induced RNA:DNA G-Quadruplex Structures Elicit an Anticancer Effect by Inhibiting Endogenous eIF-4E Expression

(2014) Debmalya Bhattacharyya et al.   BIOCHEMISTRY

In the Sense of Transcription Regulation by G-Quadruplexes: Asymmetric Effects in Sense and Antisense Strands

(2014) Tani Agarwal et al.   BIOCHEMISTRY

Formation of G-Quadruplexes in Poly-G Sequences: Structure of a Propeller-Type Parallel-Stranded G-Quadruplex Formed by a G15 Stretch

(2014) Anjali Sengar et al.   BIOCHEMISTRY

Formation of a Stacked Dimeric G-Quadruplex Containing Bulges by the 5′-Terminal Region of Human Telomerase RNA (hTERC)

(2014) Herry Martadinata et al.   BIOCHEMISTRY

U3 Region in the HIV-1 Genome Adopts a G-Quadruplex Structure in Its RNA and DNA Sequence

(2014) Dorota Piekna-Przybylska et al.   BIOCHEMISTRY

A newly identified G-quadruplex as a potential target regulating Bcl-2 expression

(2014) Hongxia Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of G-quadruplex located at 5ʹ end of mRNAs

(2014) Prachi Agarwala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Triplex intermediates in folding of human telomeric quadruplexes probed by microsecond-scale molecular dynamics simulations

(2014) Petr Stadlbauer et al.   BIOCHIMIE

Relative stability of G-quadruplex structures: Interactions between the human Bcl2 promoter region and derivatives of carbazole and diphenylamine

(2014) Sheh-Yi Sheu et al.   BIOPOLYMERS

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints

(2014) Dawei W Dong et al.   BMC GENOMICS

Positive supercoiling affiliated with nucleosome formation repairs non-B DNA structures

(2014) Dawei Li et al.   CHEMICAL COMMUNICATIONS

A Matter of Location: Influence of G-Quadruplexes on Escherichia coli Gene Expression

(2014) Isabelle T. Holder et al.   CHEMISTRY & BIOLOGY

Switchable Enzyme/DNAzyme Cascades by the Reconfiguration of DNA Nanostructures

(2014) Yuwei Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells

(2014) D. Schiavone et al.   EMBO JOURNAL

G4 motifs affect origin positioning and efficiency in two vertebrate replicators

(2014) A.-L. Valton et al.   EMBO JOURNAL

N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes

(2014) Navin C. Sabharwal et al.   FEBS Journal

Folding and Unfolding Pathways of the Human Telomeric G-Quadruplex

(2014) Robert D. Gray et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel Interaction of the Z-DNA Binding Domain of Human ADAR1 with the Oncogenic c-Myc Promoter G-Quadruplex

(2014) Hyun-Jin Kang et al.   JOURNAL OF MOLECULAR BIOLOGY

Kinetics and Structures on the Molecular Path to the Quadruplex Form of the Human Telomere

(2014) W. David Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Joining of Multiple Duplex Stems at a Single Quadruplex Loop

(2014) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Conformational Dynamics of a Stacked Dimeric G-Quadruplex Formed by the Human CEB1 Minisatellite

(2014) Michael Adrian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Manipulation of DNA:RNA Hybrid G-Quadruplex Formation in Transcription of G-Rich DNA

(2014) Jia-yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Twice-As-Smart Synthetic G-Quartet: PyroTASQ Is Both a Smart Quadruplex Ligand and a Smart Fluorescent Probe

(2014) Aurélien Laguerre et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Quantification of Loop Interaction and π–π Stacking for G-Quadruplex Stability at the Submolecular Level

(2014) Chiran Ghimire et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

(2014) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules

(2014) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topology of a DNA G-Quadruplex Structure Formed in the HIV-1 Promoter: A Potential Target for Anti-HIV Drug Development

(2014) Samir Amrane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantification of Topological Coupling between DNA Superhelicity and G-quadruplex Formation

(2014) Sangeetha Selvam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter

(2014) Margaret Hsin-Jui Kuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction of G-Quadruplexes in the Full-Length 3′ Human Telomeric Overhang

(2014) Jibin Abraham Punnoose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

(2014) Pierre Murat et al.   Nature Chemical Biology

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore

(2014) Hao Huang et al.   Nature Chemical Biology

G-quadruplex conformation and dynamics are determined by loop length and sequence

(2014) Ramreddy Tippana et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex binding enantiomers show chiral selective interactions with human telomere

(2014) Jiasi Wang et al.   NUCLEIC ACIDS RESEARCH

Mechanistic insight into ligand binding to G-quadruplex DNA

(2014) Francesco Saverio Di Leva et al.   NUCLEIC ACIDS RESEARCH

Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition

(2014) T. Hayashi et al.   NUCLEIC ACIDS RESEARCH

Loss of loop adenines alters human telomere d[AG3(TTAG3)3] quadruplex folding

(2014) Martin Babinský et al.   NUCLEIC ACIDS RESEARCH

Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL

(2014) Yunxi Cui et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad

(2014) Diana Zhang et al.   NUCLEIC ACIDS RESEARCH

Dynamics and stability of polymorphic human telomeric G-quadruplex under tension

(2014) Huijuan You et al.   NUCLEIC ACIDS RESEARCH

G-triplex structure and formation propensity

(2014) Linda Cerofolini et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of RNA guanine-quadruplex binding proteins

(2014) Annekathrin von Hacht et al.   NUCLEIC ACIDS RESEARCH

Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase

(2014) Lance M. Hellman et al.   NUCLEIC ACIDS RESEARCH

HRASis silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property

(2014) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches

(2014) Samuel G. Rouleau et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes in viruses: function and potential therapeutic applications

(2014) Mathieu Métifiot et al.   NUCLEIC ACIDS RESEARCH

Detection of Cell Carcinogenic Transformation by a Quadruplex DNA Binding Fluorescent Probe

(2014) Tsung-Lin Yang et al.   PLoS One

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues

(2014) Giulia Biffi et al.   PLoS One

An Improved Model for the hTERT Promoter Quadruplex

(2014) Jonathan B. Chaires et al.   PLoS One

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

(2014) S. Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The folding of 5'-UTR human G-quadruplexes possessing a long central loop

(2014) R. Jodoin et al.   RNA

Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins

(2014) Helen Hwang et al.   STRUCTURE

Multiple types of logic gates based on a single G-quadruplex DNA strand

(2014) Yahui Guo et al.   Scientific Reports

R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

(2014) Matthias Groh et al.   PLoS Genetics

Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology

(2014) Emilio Cusanelli et al.   Wiley Interdisciplinary Reviews-RNA

Duplex–quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer

(2013) Irene Russo Krauss et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Basis of DNA Quadruplex-Duplex Junction Formation

(2013) Kah Wai Lim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Suppression of Gene Expression by G-Quadruplexes in Open Reading Frames Depends on G-Quadruplex Stability

(2013) Tamaki Endoh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Thermal Stability of DNA Quadruplex–Duplex Hybrids

(2013) Kah Wai Lim et al.   BIOCHEMISTRY

Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K+ Solution

(2013) Herry Martadinata et al.   BIOCHEMISTRY

Multiple and Cooperative Binding of Fluorescence Light-up Probe Thioflavin T with Human Telomere DNA G-Quadruplex

(2013) Valérie Gabelica et al.   BIOCHEMISTRY

Effect of Loop Sequence and Loop Length on the Intrinsic Fluorescence of G-Quadruplexes

(2013) Chun Kit Kwok et al.   BIOCHEMISTRY

Human Papillomavirus G-Quadruplexes

(2013) Katarína Tlučková et al.   BIOCHEMISTRY

The G-Quadruplex Augments Translation in the 5′ Untranslated Region of Transforming Growth Factor β2

(2013) Prachi Agarwala et al.   BIOCHEMISTRY

DNA-based nanostructures: The effect of the base sequence on octamer formation from d(XGGYGGT) tetramolecular G-quadruplexes

(2013) Valentina D'Atri et al.   BIOCHIMIE

Polyelectrolyte effects in G-quadruplexes

(2013) Byul G. Kim et al.   BIOPHYSICAL CHEMISTRY

Thermal stability of quadruplex primers for highly versatile isothermal DNA amplification

(2013) Jordan Mathias et al.   BIOPHYSICAL CHEMISTRY

RPA-Mediated Unfolding of Systematically Varying G-Quadruplex Structures

(2013) Sujay Ray et al.   BIOPHYSICAL JOURNAL

Folding thermodynamics of the hybrid-1 type intramolecular human telomeric G-quadruplex

(2013) Yuen Lai Shek et al.   BIOPOLYMERS

Stability of human telomere quadruplexes at high DNA concentrations

(2013) Iva Kejnovská et al.   BIOPOLYMERS

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

Strand Invasion of DNA Quadruplexes by PNA: Comparison of Homologous and Complementary Hybridization

(2013) Anisha Gupta et al.   CHEMBIOCHEM

DNA gyrase-driven generation of a G-quadruplex from plasmid DNA

(2013) Bei Lv et al.   CHEMICAL COMMUNICATIONS

Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands

(2013) Xin-Ying Zhuang et al.   FEBS LETTERS

Characterization of the intramolecular G-quadruplex promoting activity of Est1

(2013) Qian-Jin Li et al.   FEBS LETTERS

The Disease-associated r(GGGGCC)nRepeat from theC9orf72Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures

(2013) Kaalak Reddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-quadruplexes incorporating modified constituents: a review

(2013) Janos Sagi   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Telomere Maintenance as a Target for Drug Discovery

(2013) Vijay Sekaran et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Dynamic G-Quadruplex Region Regulates the HIV-1 Long Terminal Repeat Promoter

(2013) Rosalba Perrone et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Genomes and G-Quadruplexes: For Better or for Worse

(2013) Madalena Tarsounas et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of Loops and G-Quartets on the Stability of RNA G-Quadruplexes

(2013) Satyaprakash Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Synthesis of a Single G-Quartet Platform in Water

(2013) Grant A. L. Bare et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Resolution Insight into G-Overhang Architecture

(2013) Robert Hänsel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Long-Loop G-Quadruplexes Are Misfolded Population Minorities with Fast Transition Kinetics in Human Telomeric Sequences

(2013) Deepak Koirala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruplex Structures

(2013) Wei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dramatic Effect of Furanose C2′ Substitution on Structure and Stability: Directing the Folding of the Human Telomeric Quadruplex with a Single Fluorine Atom

(2013) Nerea Martín-Pintado et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specific Binding of Modified RGG Domain in TLS/FUS to G-Quadruplex RNA: Tyrosines in RGG Domain Recognize 2′-OH of the Riboses of Loops in G-Quadruplex

(2013) Kentaro Takahama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences

(2013) Vineeth Thachappilly Mukundan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting Human Telomeric Higher-Order DNA: Dimeric G-Quadruplex Units Serve as Preferred Binding Site

(2013) Chuanqi Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

(2013) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G4-quadruplexes and genome instability

(2013) B. L. Zybailov et al.   MOLECULAR BIOLOGY

The Effect of Molecular Crowding on the Stability of Human c-MYC Promoter Sequence I-Motif at Neutral pH

(2013) Jingjing Cui et al.   MOLECULES

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

(2013) Justin D. Lormand et al.   NUCLEIC ACIDS RESEARCH

Controlling the stoichiometry and strand polarity of a tetramolecular G-quadruplex structure by using a DNA origami frame

(2013) A. Rajendran et al.   NUCLEIC ACIDS RESEARCH

Stimulation of ribosomal frameshifting by RNA G-quadruplex structures

(2013) Chien-Hung Yu et al.   NUCLEIC ACIDS RESEARCH

Quadruplex-forming sequences occupy discrete regions inside plant LTR retrotransposons

(2013) M. Lexa et al.   NUCLEIC ACIDS RESEARCH

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

(2013) Robert Buscaglia et al.   NUCLEIC ACIDS RESEARCH

New scoring system to identify RNA G-quadruplex folding

(2013) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands

(2013) Ting-Yuan Tseng et al.   NUCLEIC ACIDS RESEARCH

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

(2013) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli

(2013) Xiangjun Du et al.   NUCLEIC ACIDS RESEARCH

Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

(2013) Sara Chiarella et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions

(2013) Soma Dhakal et al.   NUCLEIC ACIDS RESEARCH

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

(2013) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

DNA G-quadruplex formation in response to remote downstream transcription activity: long-range sensing and signal transducing in DNA double helix

(2013) C. Zhang et al.   NUCLEIC ACIDS RESEARCH

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

(2013) Maja Marušič et al.   NUCLEIC ACIDS RESEARCH

Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals

(2013) Shan Xiao et al.   NUCLEIC ACIDS RESEARCH

Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control

(2013) Ke-wei Zheng et al.   NUCLEIC ACIDS RESEARCH

Mechanical unfolding of human telomere G-quadruplex DNA probed by integrated fluorescence and magnetic tweezers spectroscopy

(2013) Xi Long et al.   NUCLEIC ACIDS RESEARCH

Distance-dependent duplex DNA destabilization proximal to G-quadruplex/ i -motif sequences

(2013) Sebastian L. B. König et al.   NUCLEIC ACIDS RESEARCH

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

(2013) E. Salvati et al.   NUCLEIC ACIDS RESEARCH

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

(2013) Céline Douarre et al.   NUCLEIC ACIDS RESEARCH

Specific recognition and stabilization of monomeric and multimeric G-quadruplexes by cationic porphyrin TMPipEOPP under molecular crowding conditions

(2013) Li-Na Zhu et al.   NUCLEIC ACIDS RESEARCH

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening

(2013) Jean-Denis Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity

(2013) Kah Wai Lim et al.   NUCLEIC ACIDS RESEARCH

Microsatellite Tandem Repeats Are Abundant in Human Promoters and Are Associated with Regulatory Elements

(2013) Sterling Sawaya et al.   PLoS One

Kinetic Partitioning Modulates Human Telomere DNA G-Quadruplex Structural Polymorphism

(2013) Xi Long et al.   PLoS One

Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects in the Loops

(2013) Giovanna Sattin et al.   PLoS One

G-quadruplex structures are stable and detectable in human genomic DNA

(2013) Enid Yi Ni Lam et al.   Nature Communications

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

(2012) Marco Di Antonio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stability and Structure of Long Intramolecular G-Quadruplexes

(2012) Linda Payet et al.   BIOCHEMISTRY

The abasic site lesions in the human telomeric sequence d[TA(G3T2A)3G3]: A thermodynamic point of view

(2012) Antonella Virgilio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

G-ruption: The third international meeting on G-quadruplex and G-assembly

(2012) Liliya A. Yatsunyk et al.   BIOCHIMIE

G-Quadruplex and i-Motif Are Mutually Exclusive in ILPR Double-Stranded DNA

(2012) Soma Dhakal et al.   BIOPHYSICAL JOURNAL

New insights into replication origin characteristics in metazoans

(2012) Christelle Cayrou et al.   CELL CYCLE

Conformations of individual quadruplex units studied in the context of extended human telomeric DNA

(2012) Vijay Singh et al.   CHEMICAL COMMUNICATIONS

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

(2012) John A. Brazier et al.   CHEMICAL COMMUNICATIONS

Targeting DNA G-Quadruplex Structures with Peptide Nucleic Acids

(2012) Igor G. Panyutin et al.   CURRENT PHARMACEUTICAL DESIGN

The Polymorphisms of DNA G-Quadruplex Investigated by Docking Experiments with Telomestatin Enantiomers

(2012) Stefano Alcaro et al.   CURRENT PHARMACEUTICAL DESIGN

G-Quadruplex Binding Ligands: from Naturally Occurring to Rationally Designed Molecules

(2012) Tuong Vy Thi Le et al.   CURRENT PHARMACEUTICAL DESIGN

‘Intelligent’ ribozyme whose activity is altered in response to K+ as a result of quadruplex formation

(2012) Takashi Nagata et al.   FEBS Journal

Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility

(2012) Vijeth K. Katapadi et al.   GENOMICS

Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres

(2012) Yan Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYCPromoter

(2012) Angelo Gallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coexistence of G-quadruplex and duplex domains within the secondary structure of 31-mer DNA thrombin-binding aptamer

(2012) N.G. Dolinnaya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

G-Quadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?

(2012) Luigi Petraccone et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Replication Protein A Unfolds G-Quadruplex Structures with Varying Degrees of Efficiency

(2012) Mohammad H. Qureshi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Human Telomere Sequence DNA in Water-Free and High-Viscosity Solvents: G-Quadruplex Folding Governed by Kramers Rate Theory

(2012) Ford M. Lannan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beads-on-a-String Structure of Long Telomeric DNAs under Molecular Crowding Conditions

(2012) Haiqing Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Energetic Basis of Human Telomeric DNA Folding into G-Quadruplex Structures

(2012) Matjaž Bončina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An RNA Hairpin to G-Quadruplex Conformational Transition

(2012) Anthony Bugaut et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids

(2012) Amy Y. Q. Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation of Pearl-Necklace Monomorphic G-Quadruplexes in the Human CEB25 Minisatellite

(2012) Samir Amrane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tertiary DNA Structure in the Single-Stranded hTERT Promoter Fragment Unfolds and Refolds by Parallel Pathways via Cooperative or Sequential Events

(2012) Zhongbo Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

(2012) Giulia Biffi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Model of Smart G-Quadruplex Ligand

(2012) Romain Haudecoeur et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circular dichroism and guanine quadruplexes

(2012) Michaela Vorlíčková et al.   METHODS

Experimental approaches to identify cellular G-quadruplex structures and functions

(2012) Marco Di Antonio et al.   METHODS

Methods of studying telomere damage induced by quadruplex-ligand complexes

(2012) Angela Rizzo et al.   METHODS

NMR spectroscopy of G-quadruplexes

(2012) Michael Adrian et al.   METHODS

Functional complexity and regulation through RNA dynamics

(2012) Elizabeth A. Dethoff et al.   NATURE

G4 DNA in cells: itae missa est?

(2012) Jean-Louis Mergny   Nature Chemical Biology

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Engineering of interlocked DNA G-quadruplexes as a robust scaffold

(2012) Anh Tuân Phan et al.   NUCLEIC ACIDS RESEARCH

Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol

(2012) Zi-Fu Wang et al.   NUCLEIC ACIDS RESEARCH

Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals

(2012) Aradhita Baral et al.   NUCLEIC ACIDS RESEARCH

Kinetics and mechanism of G-quadruplex formation and conformational switch in a G-quadruplex of PS2.M induced by Pb2+

(2012) W. Liu et al.   NUCLEIC ACIDS RESEARCH

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

Strand directionality affects cation binding and movement within tetramolecular G-quadruplexes

(2012) Primož Šket et al.   NUCLEIC ACIDS RESEARCH

Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study

(2012) Jan Palacký et al.   NUCLEIC ACIDS RESEARCH

The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

(2012) Mark J. Morris et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation

(2012) Nicolas Beaume et al.   NUCLEIC ACIDS RESEARCH

A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex [d(TGGGGT)] 4 and cyanine dye 2,2′-diethyl-9-methyl-selenacarbocyanine bromide

(2012) Wei Gai et al.   NUCLEIC ACIDS RESEARCH

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

(2012) George R. Clark et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

(2012) D. Wei et al.   NUCLEIC ACIDS RESEARCH

Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

(2012) Filippo Doria et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Single-Molecule Study ofG-Quadruplex Disruption Using Dynamic Force Spectroscopy

(2012) Michel de Messieres et al.   PHYSICAL REVIEW LETTERS

Chiral Ruthenium(II) Polypyridyl Complexes: Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity and Cellular Uptake

(2012) Qianqian Yu et al.   PLoS One

Potential G-quadruplexes in the human long non-coding transcriptome

(2012) Gopal Gunanathan Jayaraj et al.   RNA Biology

RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes

(2012) Vitaly Kuryavyi et al.   STRUCTURE

Theoretical Analysis of Competing Conformational Transitions in Superhelical DNA

(2012) Dina Zhabinskaya et al.   PLoS Computational Biology

G-quadruplexes in RNA biology

(2012) Stefania Millevoi et al.   Wiley Interdisciplinary Reviews-RNA

An Acyclic Oligoheteroaryle That Discriminates Strongly between Diverse G-Quadruplex Topologies

(2011) Florian Hamon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Topological Characterization of Nucleic Acid G-Quadruplexes by UV Absorption and Circular Dichroism

(2011) Andreas Ioannis Karsisiotis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G-Quadruplex Motifs Arranged in Tandem Occurring in Telomeric Repeats and the Insulin-Linked Polymorphic Region

(2011) Luboš Bauer et al.   BIOCHEMISTRY

Structure of Long Human Telomeric RNA (TERRA): G-Quadruplexes Formed by Four and Eight UUAGGG Repeats Are Stable Building Blocks

(2011) Herry Martadinata et al.   BIOCHEMISTRY

A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology

(2011) Amy Y. Q. Zhang et al.   BIOCHEMISTRY

The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective

(2011) Claudia Sissi et al.   BIOCHIMIE

A structural analysis of G-quadruplex/ligand interactions

(2011) Shozeb M. Haider et al.   BIOCHIMIE

Binding properties of human telomeric quadruplex multimers: A new route for drug design

(2011) Annunziata Cummaro et al.   BIOCHIMIE

The stability of intramolecular DNA G-quadruplexes compared with other macromolecules

(2011) Andrew N. Lane   BIOCHIMIE

Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands

(2011) Akash K. Jain et al.   BIOCONJUGATE CHEMISTRY

Linkage of cation binding and folding in human telomeric quadruplex DNA

(2011) Robert D. Gray et al.   BIOPHYSICAL CHEMISTRY

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Efficient Suppression of Gene Expression by Targeting 5′-UTR-Based RNA Quadruplexes with Bisquinolinium Compounds

(2011) Kangkan Halder et al.   CHEMBIOCHEM

Hydration is Required in DNA G-Quadruplex-Protein Binding

(2011) Satoru Nagatoishi et al.   CHEMBIOCHEM

Metallo-responsive switching between hexadecameric and octameric supramolecular G-quadruplexes

(2011) Mariana Martín-Hidalgo et al.   CHEMICAL COMMUNICATIONS

Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation

(2011) Mariangela Faudale et al.   CHEMICAL COMMUNICATIONS

Quadruplex DNA: A Promising Drug Target for the Medicinal Inorganic Chemist

(2011) Stephen F. Ralph   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Human DHX9 helicase preferentially unwinds RNA-containing displacement loops (R-loops) and G-quadruplexes

(2011) Prasun Chakraborty et al.   DNA REPAIR

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

G4 DNA: at risk in the genome

(2011) Luther Davis et al.   EMBO JOURNAL

HIV-1 Nucleocapsid Protein Increases Strand Transfer Recombination by Promoting Dimeric G-quartet Formation

(2011) Wen Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Stability of Higher-Order Human Telomeric Quadruplexes

(2011) Luigi Petraccone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward a Digital Gene Response: RNA G-Quadruplexes with Fewer Quartets Fold with Higher Cooperativity

(2011) Melissa A. Mullen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced Photocleavage Footprinting

(2011) Ke-wei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-Quadruplexes: From Guanine Gels to Chemotherapeutics

(2011) Tracy M. Bryan et al.   MOLECULAR BIOTECHNOLOGY

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

(2011) Deepak Koirala et al.   Nature Chemistry

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

(2011) Anh Tuân Phan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity†

(2011) Ngoc Quang Do et al.   NUCLEIC ACIDS RESEARCH

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads

(2011) Nicola Borbone et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence

(2011) Xiaotian Tong et al.   NUCLEIC ACIDS RESEARCH

Cation binding to 15-TBA quadruplex DNA is a multiple-pathway cation-dependent process

(2011) Roman V. Reshetnikov et al.   NUCLEIC ACIDS RESEARCH

Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

(2011) Xiaohui Cang et al.   NUCLEIC ACIDS RESEARCH

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

(2011) J. Eddy et al.   NUCLEIC ACIDS RESEARCH

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability

(2011) Raveendra I. Mathad et al.   NUCLEIC ACIDS RESEARCH

HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges

(2011) Vineeth Thachappilly Mukundan et al.   NUCLEIC ACIDS RESEARCH

Mapping the sequences of potential guanine quadruplex motifs

(2011) Alan K. Todd et al.   NUCLEIC ACIDS RESEARCH

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

(2011) Eun-Ang Raiber et al.   NUCLEIC ACIDS RESEARCH

Disordering of Human Telomeric G-Quadruplex with Novel Antiproliferative Anthrathiophenedione

(2011) Dmitry Kaluzhny et al.   PLoS One

An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation

(2011) Amit Arora et al.   RNA Biology

Research Progress of RNA Quadruplex

(2011) Xiaohui Ji et al.   Nucleic Acid Therapeutics

Self-dissociative primers for nucleic acid amplification and detection based on DNA quadruplexes with intrinsic fluorescence

(2010) Besik I. Kankia   ANALYTICAL BIOCHEMISTRY

Interaction of Metal Complexes with G-Quadruplex DNA

(2010) Savvas N. Georgiades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH-Mediated Fluorescence and G-Quadruplex Binding of Amido Phthalocyanines

(2010) Jawad Alzeer et al.   BIOCHEMISTRY

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY

Thermodynamic Stability and Folding Kinetics of the Major G-Quadruplex and Its Loop Isomers Formed in the Nuclease Hypersensitive Element in the Human c-Myc Promoter: Effect of Loops and Flanking Segments on the Stability of Parallel-Stranded Intramolecular G-Quadruplexes

(2010) Emmanuel Hatzakis et al.   BIOCHEMISTRY

Monomorphic RNA G-Quadruplex and Polymorphic DNA G-Quadruplex Structures Responding to Cellular Environmental Factors

(2010) Dong-Hao Zhang et al.   BIOCHEMISTRY

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

(2010) Sonja M. Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

(2010) Arivazhagan Rajendran et al.   CHEMICAL COMMUNICATIONS

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

Structure, location and interactions of G-quadruplexes

(2010) Julian L. Huppert   FEBS Journal

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding

(2010) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An RNA G-Quadruplex Is Essential for Cap-Independent Translation Initiation in Human VEGF IRES

(2010) Mark J. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures

(2010) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coexistence of Two Distinct G-Quadruplex Conformations in the hTERT Promoter

(2010) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3)

(2010) M. Clarke Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence

(2010) Magdalena M. Dailey et al.   NUCLEIC ACIDS RESEARCH

Kinetically governed polymorphism of d(G 4 T 4 G 3 ) quadruplexes in K + solutions

(2010) Iztok Prislan et al.   NUCLEIC ACIDS RESEARCH

Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

(2010) D. Sun et al.   NUCLEIC ACIDS RESEARCH

Stability of telomeric G-quadruplexes

(2010) Phong Lan Thao Tran et al.   NUCLEIC ACIDS RESEARCH

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

Quadruplex-Duplex Motifs as New Topoisomerase I Inhibitors

(2010) Li Shuai et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence

(2010) Vitaly Kuryavyi et al.   STRUCTURE

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Selectivity in Ligand Recognition of G-Quadruplex Loops†

(2009) Nancy H. Campbell et al.   BIOCHEMISTRY

Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves

(2009) Qian Li et al.   BIOCHIMIE

Predicting and understanding the stability of G-quadruplexes

(2009) Oliver Stegle et al.   BIOINFORMATICS

A comparison of DNA and RNA quadruplex structures and stabilities

(2009) Astrid Joachimi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

Effect of flanking bases on quadruplex stability and Watson-Crick duplex competition

(2009) Amit Arora et al.   FEBS Journal

Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability

(2009) Jonathan B. Chaires   FEBS Journal

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Energetics and Kinetics of a Conformational Switch in G-Quadruplex DNA†

(2009) Robert D. Gray et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition

(2009) Zhao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A G-Rich Sequence within thec-kitOncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

(2009) Shang-Te Danny Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

(2009) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

(2009) J. Norseen et al.   JOURNAL OF VIROLOGY

Direct experimental evidence for quadruplex–quadruplex interaction within the human ILPR

(2009) Joseph D. Schonhoft et al.   NUCLEIC ACIDS RESEARCH

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

(2009) Himesh Fernando et al.   NUCLEIC ACIDS RESEARCH

Genome-wide colonization of gene regulatory elements by G4 DNA motifs

(2009) Zhuo Du et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Analyses of Recombination Prone Regions Predict Role of DNA Structural Motif in Recombination

(2009) Prithvi Mani et al.   PLoS One

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in Neisseria gonorrhoeae

(2009) L. A. Cahoon et al.   SCIENCE

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

(2009) Jinzhi Tan et al.   PLoS Pathogens

Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody†

(2008) Himesh Fernando et al.   BIOCHEMISTRY

G-Quadruplex structure: a target for anticancer therapy and a probe for detection of potassium

(2008) Bo Chen et al.   BIOCHEMISTRY-MOSCOW

Hunting G-quadruplexes

(2008) J.L. Huppert   BIOCHIMIE

Sequence effects in single-base loops for quadruplexes

(2008) Aurore Guédin et al.   BIOCHIMIE

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

Cell cycle-dependent regulation of telomere tethering in the nucleus

(2008) Katrin Paeschke et al.   CHROMOSOME RESEARCH

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes

(2008) Viktor Viglasky   FEBS Journal

Unfolding Thermodynamics of Intramolecular G-Quadruplexes: Base Sequence Contributions of the Loops†

(2008) Chris M. Olsen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Stacking and Not Solely Topology of T3Loops Controls Rigidity and Ammonium Ion Movement within d(G4T3G4)2G-Quadruplex

(2008) Peter Podbevšek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates

(2008) Katrin Paeschke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences

(2008) T. I. Gaynutdinov et al.   NUCLEIC ACIDS RESEARCH

Kinetics and mechanism of K+- and Na+-induced folding of models of human telomeric DNA into G-quadruplex structures

(2008) Robert D. Gray et al.   NUCLEIC ACIDS RESEARCH

The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements

(2008) A. K. Todd et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH

A Sequence-Independent Study of the Influence of Short Loop Lengths on the Stability and Topology of Intramolecular DNA G-Quadruplexes†

(2007) Anthony Bugaut et al.   BIOCHEMISTRY

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription

(2007) Z. Du et al.   GENOME RESEARCH

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY