The G4 Genome

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Transcription of a cis-acting, Noncoding, Small RNA Is Required for Pilin Antigenic Variation in Neisseria gonorrhoeae

(2013) Laty A. Cahoon et al.   PLoS Pathogens

G-quadruplex recognition activities of E. Coli MutS

(2012) Edward A Ehrat et al.   BMC MOLECULAR BIOLOGY

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Tandem repeat sequence variation as causative Cis-eQTLs for protein-coding gene expression variation: The case of CSTB

(2012) Christelle Borel et al.   HUMAN MUTATION

An Intramolecular G-Quadruplex Structure Is Required for Binding of Telomeric Repeat-Containing RNA to the Telomeric Protein TRF2

(2012) Giulia Biffi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs

(2012) Emilie Besnard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5′ End-Stacked Dimeric Parallel G-Quadruplexes

(2012) Vitaly Kuryavyi et al.   STRUCTURE

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

(2012) Pietro Fratta et al.   Scientific Reports

Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes SCA36, a Type of Spinocerebellar Ataxia Accompanied by Motor Neuron Involvement

(2011) Hatasu Kobayashi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

Structure of Long Human Telomeric RNA (TERRA): G-Quadruplexes Formed by Four and Eight UUAGGG Repeats Are Stable Building Blocks

(2011) Herry Martadinata et al.   BIOCHEMISTRY

A structural analysis of G-quadruplex/ligand interactions

(2011) Shozeb M. Haider et al.   BIOCHIMIE

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication

(2011) Peter Sarkies et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

G4 DNA: at risk in the genome

(2011) Luther Davis et al.   EMBO JOURNAL

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage

(2011) A. Decorsiere et al.   GENES & DEVELOPMENT

Biochemical Characterization of Warsaw Breakage Syndrome Helicase

(2011) Yuliang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA secondary structures and epigenetic determinants of cancer genome evolution

(2011) Subhajyoti De et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

(2011) J. Eddy et al.   NUCLEIC ACIDS RESEARCH

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

(2011) Eun-Ang Raiber et al.   NUCLEIC ACIDS RESEARCH

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Guanine quadruplex DNA structure restricts methylation of CpG dinucleotides genome-wide

(2010) Rashi Halder et al.   Molecular BioSystems

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination

(2010) E.-J. Uringa et al.   NUCLEIC ACIDS RESEARCH

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence

(2010) Vitaly Kuryavyi et al.   STRUCTURE

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

(2009) J. Norseen et al.   JOURNAL OF VIROLOGY

Stable G-quadruplexes are found outside nucleosome-bound regions

(2009) Han Min Wong et al.   Molecular BioSystems

Genome-wide analysis predicts DNA structural motifs as nucleosome exclusion signals

(2009) Kangkan Halder et al.   Molecular BioSystems

Selection for the G4 DNA motif at the 5′ end of human genes

(2009) Johanna Eddy et al.   MOLECULAR CARCINOGENESIS

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Genome-wide colonization of gene regulatory elements by G4 DNA motifs

(2009) Zhuo Du et al.   NUCLEIC ACIDS RESEARCH

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in Neisseria gonorrhoeae

(2009) L. A. Cahoon et al.   SCIENCE

Simian Virus 40 Large T-Antigen G-Quadruplex DNA Helicase Inhibition by G-Quadruplex DNA-Interactive Agents†

(2008) Bodin Tuesuwan et al.   BIOCHEMISTRY

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH