Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular nucleic-acid-binding protein, a transcriptional enhancer of c-Myc, promotes the formation of parallel G-quadruplexes

(2010) Mariana Borgognone et al.   BIOCHEMICAL JOURNAL

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY

Structure-Based Design of Platinum(II) Complexes as c-myc Oncogene Down-Regulators and Luminescent Probes for G-Quadruplex DNA

(2010) Ping Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

(2010) C. O. Marian et al.   CLINICAL CANCER RESEARCH

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

TheKRASPromoter Responds to Myc-associated Zinc Finger and Poly(ADP-ribose) Polymerase 1 Proteins, Which Recognize a Critical Quadruplex-formingGA-element

(2010) Susanna Cogoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrospray Mass Spectrometry of Telomeric RNA (TERRA) Reveals the Formation of Stable Multimeric G-Quadruplex Structures

(2010) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

(2010) T. Shalaby et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression

(2010) Jeny Shklover et al.   NUCLEIC ACIDS RESEARCH

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence

(2010) Magdalena M. Dailey et al.   NUCLEIC ACIDS RESEARCH

Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

(2010) D. Sun et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

(2010) Anthony Bugaut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements

(2010) Samantha Kendrick et al.   PURE AND APPLIED CHEMISTRY

The c-MYC NHE III1: Function and Regulation

(2009) Verónica González et al.   Annual Review of Pharmacology and Toxicology

Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder

(2009) Hyun-Jin Kang et al.   BIOCHEMISTRY

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

(2009) R Kumar et al.   BRITISH JOURNAL OF CANCER

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

(2009) Khondaker M. Rahman et al.   CHEMICAL COMMUNICATIONS

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity

(2009) Sabrina Lusvarghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A G-Rich Sequence within thec-kitOncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

(2009) Shang-Te Danny Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stable G-quadruplexes are found outside nucleosome-bound regions

(2009) Han Min Wong et al.   Molecular BioSystems

Genome-wide analysis predicts DNA structural motifs as nucleosome exclusion signals

(2009) Kangkan Halder et al.   Molecular BioSystems

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells

(2009) W.-J. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

(2009) T. S. Dexheimer et al.   MOLECULAR CANCER THERAPEUTICS

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

(2009) Himesh Fernando et al.   NUCLEIC ACIDS RESEARCH

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

(2009) Manikandan Paramasivam et al.   NUCLEIC ACIDS RESEARCH

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

First Evidence of a Functional Interaction between DNA Quadruplexes and Poly(ADP-ribose) Polymerase-1

(2008) V. A. Soldatenkov et al.   ACS Chemical Biology

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Genome-Wide Computational and Expression Analyses Reveal G-Quadruplex DNA Motifs as Conservedcis-Regulatory Elements in Human and Related Species

(2008) Anjali Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a New G-Quadruplex Motif in theKRASPromoter and Design of Pyrene-Modified G4-Decoys with Antiproliferative Activity in Pancreatic Cancer Cells

(2008) Susanna Cogoi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The functional response of upstream DNA to dynamic supercoiling in vivo

(2008) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

(2008) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH

Role of ATM in the telomere response to the G-quadruplex ligand 360A

(2008) Gaëlle Pennarun et al.   NUCLEIC ACIDS RESEARCH

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements

(2008) A. K. Todd et al.   NUCLEIC ACIDS RESEARCH

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH

Identification of Functional Networks of Estrogen- and c-Myc-Responsive Genes and Their Relationship to Response to Tamoxifen Therapy in Breast Cancer

(2008) Elizabeth A. Musgrove et al.   PLoS One

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription

(2007) Z. Du et al.   GENOME RESEARCH

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY