G-quadruplex nucleic acids and human disease

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

(2010) Young-Hoon Kang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

Yeast as a model system to study RecQ helicase function

(2010) Thomas M. Ashton et al.   DNA REPAIR

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Structure, location and interactions of G-quadruplexes

(2010) Julian L. Huppert   FEBS Journal

Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation

(2010) Ming-Liang Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Consecutive Formation of G-Quadruplexes in Human Telomeric-Overhang DNA: A Protective Capping Structure for Telomere Ends

(2009) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Association of Insulin-like Growth Factor 2 with the Insulin-Linked Polymorphic Region in Cultured Fetal Thymus Cells,

(2009) Yuexi Wang et al.   BIOCHEMISTRY

Purification of Proteins Associated with Specific Genomic Loci

(2009) Jérôme Déjardin et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Telomeres and disease

(2009) Peter M Lansdorp   EMBO JOURNAL

Human telomeric G-quadruplex

(2009) Souvik Maiti   FEBS Journal

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

Pif1 Helicase Lengthens Some Okazaki Fragment Flaps Necessitating Dna2 Nuclease/Helicase Action in the Two-nuclease Processing Pathway

(2009) Jason E. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significance of the Dissociation of Dna2 by Flap Endonuclease 1 to Okazaki Fragment Processing inSaccharomyces cerevisiae

(2009) Jason A. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of telomere dysfunction in aging and its detection by biomarkers

(2009) Guido von Figura et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mass spectrometric determination of ILPR G-quadruplex binding sites in insulin and IGF-2

(2009) JunFeng Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

(2009) J. P. Duxin et al.   MOLECULAR AND CELLULAR BIOLOGY

G Clustering Is Important for the Initiation of Transcription-Induced R-Loops In Vitro, whereas High G Density without Clustering Is Sufficient Thereafter

(2009) D. Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

Selection for the G4 DNA motif at the 5′ end of human genes

(2009) Johanna Eddy et al.   MOLECULAR CARCINOGENESIS

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights

(2009) Larry H. Thompson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Fanconi anemia and its diagnosis

(2009) Arleen D. Auerbach   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

(2009) Himesh Fernando et al.   NUCLEIC ACIDS RESEARCH

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

(2009) Manikandan Paramasivam et al.   NUCLEIC ACIDS RESEARCH

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells

(2009) Anjali Verma et al.   NUCLEIC ACIDS RESEARCH

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

(2009) Nassima Temime-Smaali et al.   PLoS One

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Human Replication Protein A Melts a DNA Triple Helix Structure in a Potent and Specific Manner†

(2008) Yuliang Wu et al.   BIOCHEMISTRY

Hunting G-quadruplexes

(2008) J.L. Huppert   BIOCHIMIE

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

Telomere maintenance and human bone marrow failure

(2008) R. T. Calado et al.   BLOOD

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

(2008) A. J. Walne et al.   BLOOD

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Welcome the Family of FANCJ-like Helicases to the Block of Genome Stability Maintenance Proteins

(2008) Y. Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genomic Stability: FANCJ-Dependent G4 DNA Repair

(2008) Nancy Maizels   CURRENT BIOLOGY

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU

(2008) Fumiko Iwamoto et al.   EXPERIMENTAL CELL RESEARCH

Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

(2008) Taro Masuda-Sasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation Spectra in Fragile X Syndrome Induced by Deletions of CGG·CCG Repeats

(2008) Robert D. Wells   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL

The genetic and molecular basis of Fanconi anemia

(2008) Johan P. de Winter et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

(2008) T. Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY