Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules

(2015) Bruno Pagano et al.   ChemMedChem

The G-quadruplex-stabilising agent RHPS4 induces telomeric dysfunction and enhances radiosensitivity in glioblastoma cells

(2015) F. Berardinelli et al.   DNA REPAIR

Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites

(2015) A. Piazza et al.   EMBO JOURNAL

High-throughput sequencing of DNA G-quadruplex structures in the human genome

(2015) Vicki S Chambers et al.   NATURE BIOTECHNOLOGY

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

(2015) Erica Salvati et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Small-molecule quadruplex-targeted drug discovery

(2014) Stephan A. Ohnmacht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

(2014) Ann Zeuner et al.   Cell Stem Cell

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

(2014) Angela Rizzo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation

(2014) O Shimozato et al.   ONCOGENE

RHPS4 G-Quadruplex Ligand Induces Anti-Proliferative Effects in Brain Tumor Cells

(2014) Sunil Lagah et al.   PLoS One

Hepatocellular carcinoma: Surgical perspectives beyond the barcelona clinic liver cancer recommendations

(2014) Alfredo Guglielmi   WORLD JOURNAL OF GASTROENTEROLOGY

G-quadruplex interacting small molecules and drugs: from bench toward bedside

(2014) Sebastian Müller et al.   Expert Review of Clinical Pharmacology

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

(2013) Sara Iachettini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

(2013) E. Salvati et al.   NUCLEIC ACIDS RESEARCH

G4 motifs in human genes

(2012) Nancy Maizels   Annals of the New York Academy of Sciences

Aromatic Core Extension in the Series of N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells

(2012) Marco Franceschin et al.   ChemMedChem

State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders

(2012) Bruno Pagano et al.   CURRENT PHARMACEUTICAL DESIGN

CD133 as a target for colon cancer

(2012) Veronica Catalano et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

(2012) Anthony B. Mak et al.   Cell Reports

DNA acting like RNA

(2011) Robert V. Brown et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

(2011) A. Biroccio et al.   CLINICAL CANCER RESEARCH

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron

(2010) W. C. Reinhold et al.   CANCER RESEARCH

The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

(2010) K. Kemper et al.   CANCER RESEARCH

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

How long is too long? Effects of loop size on G-quadruplex stability

(2010) Aurore Guédin et al.   NUCLEIC ACIDS RESEARCH

A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

(2010) Dennis Gomez et al.   NUCLEIC ACIDS RESEARCH

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer

(2010) Tarek M. A. Elsaba et al.   PLoS One

Prognostic Significance of the Cancer Stem Cell Markers CD133, CD44, and CD166 in Colorectal Cancer

(2009) David Horst et al.   CANCER INVESTIGATION

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors

(2008) C. Leonetti et al.   CLINICAL CANCER RESEARCH

The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer

(2008) Marie-Cécile Didiot et al.   NUCLEIC ACIDS RESEARCH

Cancer stem cell markers in common cancers – therapeutic implications

(2008) Thomas Klonisch et al.   TRENDS IN MOLECULAR MEDICINE