KRASpromoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts

(2014) Vojč Kocman et al.   Nature Communications

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

(2013) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene

(2012) Marko Trajkovski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops

(2012) Maja Marušič et al.   NUCLEIC ACIDS RESEARCH

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE

(2011) Manikandan Paramasivam et al.   CHEMICAL COMMUNICATIONS

Formation of (3+1) G-Quadruplexes with a Long Loop by Human Telomeric DNA Spanning Five or More Repeats

(2011) Doris Jia En Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

TheKRASPromoter Responds to Myc-associated Zinc Finger and Poly(ADP-ribose) Polymerase 1 Proteins, Which Recognize a Critical Quadruplex-formingGA-element

(2010) Susanna Cogoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of a New G-Quadruplex Motif in theKRASPromoter and Design of Pyrene-Modified G4-Decoys with Antiproliferative Activity in Pancreatic Cancer Cells

(2008) Susanna Cogoi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation

(2008) Manikandan Paramasivam et al.   NUCLEIC ACIDS RESEARCH

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins

(2008) Susanna Cogoi et al.   NUCLEIC ACIDS RESEARCH

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY