Duplex–quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer

An Overview of Biological Macromolecule Crystallization

(2013) Irene Russo Krauss et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Folding Versus Charge: Understanding Selective Target Recognition by the Thrombin Aptamers

(2012) Giuseppe Marson et al.   CURRENT PHARMACEUTICAL DESIGN

Coexistence of G-quadruplex and duplex domains within the secondary structure of 31-mer DNA thrombin-binding aptamer

(2012) N.G. Dolinnaya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

(2012) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

(2012) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding

(2011) Satoru Nagatoishi et al.   BIOCHIMIE

Studies of the binding mechanism between aptamers and thrombin by circular dichroism, surface plasmon resonance and isothermal titration calorimetry

(2011) Po-Hsun Lin et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Novel Modular DNA Aptamer for Human Thrombin with High Anticoagulant Activity

(2011) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

Increased anticoagulant activity of thrombin-binding DNA aptamers by nanoscale organization on DNA nanostructures

(2011) Abhijit Rangnekar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

(2011) Anh Tuân Phan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thrombin–aptamer recognition: a revealed ambiguity

(2011) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Molecular aptamers for drug delivery

(2011) Weihong Tan et al.   TRENDS IN BIOTECHNOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and preliminary X-ray analysis of the complex of human α-thrombin with a modified thrombin-binding aptamer

(2010) Irene Russo Krauss et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The binding effect of aptamers on thrombin

(2010) Guiping Zhou et al.   BIOCHEMICAL ENGINEERING JOURNAL

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

Differential Regulation of Protein Subdomain Activity with Caged Bivalent Ligands

(2009) Günter Mayer et al.   CHEMBIOCHEM

Nucleic Acid Aptamers Based on the G-Quadruplex Structure: Therapeutic and Diagnostic Potential

(2009) B. Gatto et al.   CURRENT MEDICINAL CHEMISTRY

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression

(2009) Himesh Fernando et al.   NUCLEIC ACIDS RESEARCH

A Grafting Strategy for the Design of Improved G-Quadruplex Aptamers and High-Activity DNAzymes

(2009) Tao Li et al.   PLoS One

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase

(2008) J. MÜLLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

Improvement of Aptamer Affinity by Dimerization

(2008) Hijiri Hasegawa et al.   SENSORS