Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

G-quadruplex structures are stable and detectable in human genomic DNA

(2013) Enid Yi Ni Lam et al.   Nature Communications

A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines

(2012) Caterina M. Lombardo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Aromatic Core Extension in the Series of N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells

(2012) Marco Franceschin et al.   ChemMedChem

State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders

(2012) Bruno Pagano et al.   CURRENT PHARMACEUTICAL DESIGN

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topological Characterization of Nucleic Acid G-Quadruplexes by UV Absorption and Circular Dichroism

(2011) Andreas Ioannis Karsisiotis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Down-regulation of the human VEGF gene expression by perylene monoimide derivatives

(2011) Thanachai Taka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage

(2011) Valentina Casagrande et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY

Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene

(2010) D. Sun et al.   NUCLEIC ACIDS RESEARCH

A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures

(2010) Stefano Masiero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors

(2008) C. Leonetti et al.   CLINICAL CANCER RESEARCH

Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes

(2008) Viktor Viglasky   FEBS Journal

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY