Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo

(2009) Mekala Gunaratnam et al.   BIOCHEMICAL PHARMACOLOGY

Selectivity in Ligand Recognition of G-Quadruplex Loops†

(2009) Nancy H. Campbell et al.   BIOCHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

(2009) Khondaker M. Rahman et al.   CHEMICAL COMMUNICATIONS

Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand

(2009) N. Arnoult et al.   CYTOGENETIC AND GENOME RESEARCH

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

First Evidence of a Functional Interaction between DNA Quadruplexes and Poly(ADP-ribose) Polymerase-1

(2008) V. A. Soldatenkov et al.   ACS Chemical Biology

TRAP–LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules

(2008) Julie Reed et al.   ANALYTICAL BIOCHEMISTRY

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

G-quadruplex recognition by bis-indole carboxamides

(2008) Jyotirmayee Dash et al.   CHEMICAL COMMUNICATIONS

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors

(2008) C. Leonetti et al.   CLINICAL CANCER RESEARCH

Rational Design of Substituted Diarylureas: A Scaffold for Binding to G-Quadruplex Motifs

(2008) William C. Drewe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-Wide Computational and Expression Analyses Reveal G-Quadruplex DNA Motifs as Conservedcis-Regulatory Elements in Human and Related Species

(2008) Anjali Verma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates

(2008) Katrin Paeschke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fission Yeast Pot1-Tpp1 Protects Telomeres and Regulates Telomere Length

(2008) T. Miyoshi et al.   SCIENCE

Telomere instability and cancer

(2007) J. Arturo Londoño-Vallejo   BIOCHIMIE

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY