Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

(2019) Lei Liu et al.   JOURNAL OF CELL BIOLOGY

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases

(2019) Konstantin Karmilin et al.   Scientific Reports

Glutamate receptor trafficking and protein synthesis mediate the facilitation of ltp by secreted amyloid precursor protein-alpha

(2019) Bruce G. Mockett et al.   JOURNAL OF NEUROSCIENCE

Mammalian legumain – A lysosomal cysteine protease with extracellular functions?

(2019) Ngoc Nguyen Lunde et al.   BIOCHIMIE

Matrix metalloproteinases in the CNS: interferons get nervous

(2019) Sameeksha Chopra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Matrix metalloproteinases and ADAMs in stroke

(2019) Joan Montaner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Matrix metalloproteinase signals following neurotrauma are right on cue

(2019) Alpa Trivedi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MMPs and ADAMs in neurological infectious diseases and multiple sclerosis

(2019) Lukas Muri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders

(2019) Santiago Rivera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MMPs in learning and memory and neuropsychiatric disorders

(2019) Anna Beroun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

(2019) Zoë P. Van Acker et al.   Molecular Neurodegeneration

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

(2019) Filip Liebsch et al.   Nature Communications

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain

(2018) Wei Hong et al.   ACTA NEUROPATHOLOGICA

Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia

(2018) Gustavo Basurto-Islas et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes

(2018) Lauren K. Fong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient increase in sAPPα secretion in response to Aβ1–42 oligomers: an attempt of neuronal self-defense?

(2018) Christiane Rose et al.   NEUROBIOLOGY OF AGING

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3xTgAD and 2xTgAD mice

(2018) Alexandre Bourgeois et al.   NEUROBIOLOGY OF AGING

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

(2018) Valerie T. Y. Tan et al.   Molecular Brain

The discovery of proteases and intramembrane proteolysis

(2018) Sandra Paschkowsky et al.   Biochemistry and Cell Biology

Plasma Fetuin-A is Associated with the Severity of Cognitive Impairment in Mild-to-Moderate Alzheimer's Disease

(2018) Edward R. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Concentrations of Matrix Metalloproteinases and their Tissue Inhibitors in the Cerebrospinal Fluid of Patients with Alzheimer's Disease

(2018) Barbara Mroczko et al.   JOURNAL OF ALZHEIMERS DISEASE

Membrane cholesterol as regulator of human rhomboid protease RHBDL4.

(2018) Sandra Paschkowsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

(2018) Jean-Michel Paumier et al.   FASEB JOURNAL

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

(2018) Jichao Sun et al.   Nature Communications

Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia

(2017) Alina Aguirre et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Chronic treatments with a 5-HT 4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

(2017) Kevin Baranger et al.   NEUROPHARMACOLOGY

Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s disease

(2017) Hassan Bukhari et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

(2017) Zhentao Zhang et al.   Nature Communications

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

(2017) Riqiang Yan   Frontiers in Molecular Neuroscience

The Role of APP in Structural Spine Plasticity

(2017) Elena Montagna et al.   Frontiers in Molecular Neuroscience

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

(2017) Klemens Wild et al.   Frontiers in Molecular Neuroscience

Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease

(2017) Xin Wang et al.   Frontiers in Molecular Neuroscience

MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

(2017) Kévin Baranger et al.   Frontiers in Molecular Neuroscience

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

(2017) Christoph Becker-Pauly et al.   Frontiers in Molecular Neuroscience

C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease

(2017) María-Salud García-Ayllón et al.   Scientific Reports

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies

(2016) Masuo Ohno   BRAIN RESEARCH BULLETIN

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer’s Disease

(2016) Patricia R. Spilman et al.   JOURNAL OF ALZHEIMERS DISEASE

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence

(2016) Ayano Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4

(2016) Sandra Paschkowsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?

(2016) Kévin Baranger et al.   Journal of Neuroinflammation

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Cerebrovascular pathology during the progression of experimental Alzheimer's disease

(2016) Patrizia Giannoni et al.   NEUROBIOLOGY OF DISEASE

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

Membrane-type matrix metalloproteinases: Their functions and regulations

(2015) Yoshifumi Itoh   MATRIX BIOLOGY

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

(2014) Stéphane D. Girard et al.   HIPPOCAMPUS

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models

(2014) D. Y. Kallop et al.   JOURNAL OF NEUROSCIENCE

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin

(2014) Eva Porlan et al.   NATURE CELL BIOLOGY

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer’s disease: evidence for a pro-amyloidogenic role of MT1-MMP

(2014) Nathalie A. Py et al.   Frontiers in Aging Neuroscience

Role of Matrix Metalloproteinases in Migration and Neurotrophic Properties of Nasal Olfactory Stem and Ensheathing Cells

(2013) Adlane Ould-Yahoui et al.   CELL TRANSPLANTATION

Recruitment of the Mint3 Adaptor Is Necessary for Export of the Amyloid Precursor Protein (APP) from the Golgi Complex

(2013) Amanda H. Caster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

(2013) W. Gibson Wood et al.   JOURNAL OF NEUROCHEMISTRY

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases

(2013) Anika Langenfurth et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Area-Specific Alterations of Synaptic Plasticity in the 5XFAD Mouse Model of Alzheimer’s Disease: Dissociation between Somatosensory Cortex and Hippocampus

(2013) Nadine Crouzin et al.   PLoS One

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

(2012) Marta Pera et al.   ACTA NEUROPATHOLOGICA

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes

(2012) Thomas Vogl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo

(2012) Lujia Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

MT5-MMP, ADAM-10, and N-Cadherin Act in Concert To Facilitate Synapse Reorganization after Traumatic Brain Injury

(2012) Kelly M. Warren et al.   JOURNAL OF NEUROTRAUMA

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

(2012) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

(2012) Keun-A Chang et al.   Neurodegenerative Diseases

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development

(2011) Guoxiang Jin et al.   EMBO JOURNAL

Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16

(2011) Amanda E. Starr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic Autoregulation by Metalloproteases and  -Secretase

(2011) S. Restituito et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Fetuin-A and Cystatin C Are Endogenous Inhibitors of Human Meprin Metalloproteases

(2010) Jana Hedrich et al.   BIOCHEMISTRY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production

(2010) Yuan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

(2010) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer’s disease transgenic mice

(2010) Ryoichi Kimura et al.   JOURNAL OF NEUROCHEMISTRY

Metzincin Proteases and Their Inhibitors: Foes or Friends in Nervous System Physiology?

(2010) S. Rivera et al.   JOURNAL OF NEUROSCIENCE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Cholesterol and statins in Alzheimer's disease: Current controversies

(2009) Ana Catarina R.G. Fonseca et al.   EXPERIMENTAL NEUROLOGY

Cytoplasmic tail of MT1-MMP regulates macrophage motility independently from its protease activity

(2009) Takeharu Sakamoto et al.   GENES TO CELLS

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by β-amyloid 25-35 fragment

(2009) Mar Hernández-Guillamon et al.   JOURNAL OF NEUROSCIENCE RESEARCH

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons

(2009) Adlane Ould-yahoui et al.   PLoS One

Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation

(2009) A. R. Folgueras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition

(2008) Magdalini Rapti et al.   BIOCHEMICAL JOURNAL

Identification of Amino Acid Residues of the Matrix Metalloproteinase-2 Essential for Its Selective Inhibition by β-Amyloid Precursor Protein-derived Inhibitor

(2008) Shouichi Higashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY