Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
Authors
Keywords
-
Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-05-20
DOI
10.1038/s41467-019-10152-w
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Comparison of Two Analytical Platforms for the Clinical Qualification of Alzheimer's Disease Biomarkers in Pathologically-Confirmed Dementia
- (2018) Nathalie Le Bastard et al. JOURNAL OF ALZHEIMERS DISEASE
- Optimizing Patient Care and Research: The Amsterdam Dementia Cohort
- (2018) Wiesje M. van der Flier et al. JOURNAL OF ALZHEIMERS DISEASE
- Validation of the AD-CSF-Index in Autopsy-Confirmed Alzheimer's Disease Patients and Healthy Controls
- (2018) Hanne Struyfs et al. JOURNAL OF ALZHEIMERS DISEASE
- Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway
- (2017) Erik Portelius et al. Molecular Neurodegeneration
- Fibril structure of amyloid-β(1–42) by cryo–electron microscopy
- (2017) Lothar Gremer et al. SCIENCE
- BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
- (2017) Martin Weber et al. Scientific Reports
- Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
- (2016) Katherine R. Sadleir et al. ACTA NEUROPATHOLOGICA
- Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence
- (2016) Ayano Kimura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
- (2016) Bob Olsson et al. LANCET NEUROLOGY
- The BACE1 inhibitor verubecestat (MK-8931) reduces CNS -amyloid in animal models and in Alzheimers disease patients
- (2016) M. E. Kennedy et al. Science Translational Medicine
- Age and amyloid effects on human central nervous system amyloid-beta kinetics
- (2015) Bruce W. Patterson et al. ANNALS OF NEUROLOGY
- Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9
- (2015) Mar Hernandez-Guillamon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans
- (2015) Donald L. Elbert et al. MATHEMATICAL BIOSCIENCES
- Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
- (2015) Katherine R Sadleir et al. Molecular Neurodegeneration
- Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age
- (2015) Courtney L. Sutphen et al. JAMA Neurology
- Facilitating the Validation of Novel Protein Biomarkers for Dementia: An Optimal Workflow for the Development of Sandwich Immunoassays
- (2015) Marta del Campo et al. Frontiers in Neurology
- The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation
- (2014) Iryna Benilova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS
- (2014) Biljana Georgievska et al. JOURNAL OF NEUROCHEMISTRY
- Study on Aβ34 biology and detection in transgenic mice brains
- (2014) Céline Caillava et al. NEUROBIOLOGY OF AGING
- The amyloid-β degradation pattern in plasma—A possible tool for clinical trials in Alzheimer's disease
- (2014) Josef Pannee et al. NEUROSCIENCE LETTERS
- Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
- (2014) Katherine R. Sadleir et al. PLoS One
- Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease
- (2014) A. M. Fagan et al. Science Translational Medicine
- β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
- (2014) Erik Portelius et al. Alzheimers Research & Therapy
- Accuracy of Brain Amyloid Detection in Clinical Practice Using Cerebrospinal Fluid β-Amyloid 42
- (2014) Sebastian Palmqvist et al. JAMA Neurology
- The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
- (2013) Patty C. Kandalepas et al. ACTA NEUROPATHOLOGICA
- CSF biomarker variability in the Alzheimer's Association quality control program
- (2013) Niklas Mattsson et al. Alzheimers & Dementia
- Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions
- (2013) Fredrik Olsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers
- (2013) R. Potter et al. Science Translational Medicine
- Proteolytic Degradation of Amyloid -Protein
- (2013) T. Saido et al. Cold Spring Harbor Perspectives in Medicine
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System
- (2012) Niklas Mattsson et al. PLoS One
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
- (2011) Clifford R. Jack et al. ANNALS OF NEUROLOGY
- The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing
- (2011) Sabine Rabe et al. JOURNAL OF NEUROCHEMISTRY
- β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins
- (2010) Carlo Sala Frigerio et al. FEBS Journal
- The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway
- (2010) Nikolai D. Belyaev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- β-Secretase-1 elevation in transgenic mouse models of Alzheimerâs disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
- (2009) Xue-Mei Zhang et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease
- (2008) R. Deane et al. CURRENT PHARMACEUTICAL DESIGN
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More