Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

(2016) Chengyu Zou et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2

(2016) Magnus C. Mayer et al.   JOURNAL OF NEUROCHEMISTRY

Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA

(2015) Christian Dienemann et al.   BIOCHEMISTRY

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase

(2015) Edith Winkler et al.   BIOCHEMISTRY

Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms

(2015) Virgil Muresan et al.   EXPERIMENTAL CELL RESEARCH

The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain

(2015) Sandra Hoefgen et al.   JOURNAL OF MOLECULAR BIOLOGY

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

(2015) Sven O. Dahms et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structural biology of the amyloid precursor protein APP – a complex puzzle reveals its multi-domain architecture

(2014) Ina Coburger et al.   BIOLOGICAL CHEMISTRY

The main cost drivers in dementia: a systematic review

(2014) Sandra Schaller et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells

(2014) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Zinc-binding Site in the E2 Domain Regulates Amyloid Precursor-like Protein 1 (APLP1) Oligomerization

(2014) Magnus C. Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions

(2013) Ann Tiiman et al.   NEUROCHEMISTRY INTERNATIONAL

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Visualizing metal ions in cells: An overview of analytical techniques, approaches, and probes

(2012) Kevin M. Dean et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism

(2012) Loredana Spoerri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Copper signaling in the mammalian nervous system: Synaptic effects

(2012) E.D. Gaier et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Roles of the amyloid precursor protein family in the peripheral nervous system

(2012) John H. Caldwell et al.   MECHANISMS OF DEVELOPMENT

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function

(2012) Brea Midthune et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

(2011) Sangwon Lee et al.   BIOCHEMISTRY

Alzheimer's disease & metals: therapeutic opportunities

(2011) Vijaya B Kenche et al.   BRITISH JOURNAL OF PHARMACOLOGY

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

(2011) Simone Isbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biphasic effects of copper on neurotransmission in rat hippocampal neurons

(2011) Christian Peters et al.   JOURNAL OF NEUROCHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Dynamic action of neurometals at the synapse

(2011) Haruna Tamano et al.   Metallomics

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

ATP7A-related copper transport diseases—emerging concepts and future trends

(2011) Stephen G. Kaler   Nature Reviews Neurology

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

(2011) Silke Brunholz et al.   EXPERIMENTAL BRAIN RESEARCH

Structural aspects and physiological consequences of APP/APLP trans-dimerization

(2011) Frederik Baumkötter et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Synaptic organizing complexes

(2010) Tabrez J Siddiqui et al.   CURRENT OPINION IN NEUROBIOLOGY

Copper Promotes the Trafficking of the Amyloid Precursor Protein

(2010) Karla M. Acevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper handling machinery of the brain

(2010) Svetlana Lutsenko et al.   Metallomics

Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization

(2010) L. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metal Loading Capacity of Aβ N-Terminus: a Combined Potentiometric and Spectroscopic Study of Zinc(II) Complexes with Aβ(1−16), Its Short or Mutated Peptide Fragments and Its Polyethylene Glycol−ylated Analogue

(2009) Chiara A. Damante et al.   INORGANIC CHEMISTRY

Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

(2009) Simone Eggert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper in the brain and Alzheimer’s disease

(2009) Ya Hui Hung et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease

(2009) Andreana C. Leskovjan et al.   NEUROIMAGE

Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms

(2008) Michael A. Cater et al.   BIOCHEMICAL JOURNAL

Intramembrane Proteolysis by γ-Secretase

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

(2008) Pascal Kienlen-Campard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease

(2008) Michelle L. Turski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

ADAM-10 over-expression increases cortical synaptogenesis

(2006) Karen F.S. Bell et al.   NEUROBIOLOGY OF AGING