Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

(2015) Jayme L. Dahlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening-Based Translation of Public Research Encounters Painful Problems

(2015) Jonathan B. Baell   ACS Medicinal Chemistry Letters

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small Peptides Blocking Inhibition of Factor Xa and Tissue Factor-Factor VIIa by Tissue Factor Pathway Inhibitor (TFPI)

(2013) Michael Dockal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

(2013) Gustavo Basurto-Islas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Asparaginyl endopeptidase cleaves TDP-43 in brain

(2012) Jeremy H. Herskowitz et al.   PROTEOMICS

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile

(2011) Elfriede Dall et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Asparagine endopeptidase is required for normal kidney physiology and homeostasis

(2011) Gail Miller et al.   FASEB JOURNAL

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene – induced DNA damage and micronuclei in HepG2 cells

(2011) K. KOZICS et al.   NEOPLASMA

Cystatin E/M suppresses legumain activity and invasion of human melanoma

(2010) Jon J Briggs et al.   BMC CANCER

A Chloroacetamidine-Based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and In Vitro and In Vivo Evaluation

(2010) Obiamaka Obianyo et al.   CHEMBIOCHEM

The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

(2010) Krishna Mohan Bajjuri  et al.   ChemMedChem

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aza-Peptidyl Michael Acceptor and Epoxide Inhibitors—Potent and Selective Inhibitors of Schistosoma mansoni and Ixodes ricinus Legumains (Asparaginyl Endopeptidases)

(2009) Asli Ovat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis

(2008) Rong Xiang et al.   IMMUNOLOGICAL REVIEWS

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

(2008) C.-B. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA