Regulation of the alternative β-secretase meprin β by ADAM-mediated shedding

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

(2019) Lei Liu et al.   JOURNAL OF CELL BIOLOGY

Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes

(2019) Florian Peters et al.   FASEB JOURNAL

Structure of APP-C99 1–99 and implications for role of extra-membrane domains in function and oligomerization

(2018) George A. Pantelopulos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease

(2018) T. Patel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Aminoterminally Truncated and Oxidized Amyloid-β Peptides in the Cerebrospinal Fluid of Alzheimer's Disease Patients

(2018) Mirko Bibl et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

(2018) Gregory Hook et al.   JOURNAL OF ALZHEIMERS DISEASE

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation

(2018) Dagmar Schlenzig et al.   JOURNAL OF ALZHEIMERS DISEASE

Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration

(2017) Tillmann Bedau et al.   FASEB JOURNAL

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

(2017) Yan Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of Cα–H Hydrogen Bonds and van der Waals Packing Modulates the Stability of GxxxG-Mediated Dimers in Membranes

(2017) Samantha M. Anderson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro

(2017) Tillmann Bedau et al.   Oncotarget

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

(2017) Rielana Wichert et al.   Cell Reports

Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes

(2017) John E. Bylander et al.   Journal of Diabetes Research

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

(2017) Christoph Becker-Pauly et al.   Frontiers in Molecular Neuroscience

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling

(2017) Philipp Arnold et al.   Scientific Reports

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein

(2016) Laura Dominguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

(2016) Sun-Ho Han et al.   PROGRESS IN NEUROBIOLOGY

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

(2016) Simone Alidori et al.   Science Translational Medicine

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

(2016) Poomy Pandey et al.   Oncotarget

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

(2016) Marie Decock et al.   Frontiers in Aging Neuroscience

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

(2016) Florent Letronne et al.   EBioMedicine

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

(2015) Felix Jäckle et al.   BIOCHEMICAL JOURNAL

The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain

(2015) Sandra Hoefgen et al.   JOURNAL OF MOLECULAR BIOLOGY

Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways

(2015) C. Bohm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Meprin Metalloproteases Inactivate Interleukin 6

(2014) Timothy R. Keiffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A

(2014) Christian Herzog et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain

(2014) Sandra Hoefgen et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural Heterogeneity in Transmembrane Amyloid Precursor Protein Homodimer Is a Consequence of Environmental Selection

(2014) Laura Dominguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbial-induced meprin   cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

(2014) A. Schutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

(2014) Wen Chen et al.   Nature Communications

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein

(2013) Yuanli Song et al.   BIOCHEMISTRY

Metalloproteases meprin   and meprin   are C- and N-procollagen proteinases important for collagen assembly and tensile strength

(2013) C. Broder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and structural insights into astacin metallopeptidases

(2012) F. Xavier Gomis-Rüth et al.   BIOLOGICAL CHEMISTRY

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

(2012) Tamara Jefferson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment

(2012) Kirill D. Nadezhdin et al.   FEBS LETTERS

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for the sheddase function of human meprin   metalloproteinase at the plasma membrane

(2012) J. L. Arolas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Cathepsins S, B and L with aminopeptidases display β-secretase activity associated with the pathogenesis of Alzheimer’s disease

(2011) Israel Schechter et al.   BIOLOGICAL CHEMISTRY

Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein

(2011) Jun-Xia Lu et al.   BIOPHYSICAL JOURNAL

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates

(2011) Christoph Becker-Pauly et al.   MOLECULAR & CELLULAR PROTEOMICS

Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease

(2010) Sanjita Banerjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators

(2010) Anne Botev et al.   BIOCHEMISTRY

Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

(2010) Anke Ohler et al.   BIOLOGICAL CHEMISTRY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Processing of Procollagen III by Meprins: New Players in Extracellular Matrix Assembly?

(2010) Daniel Kronenberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

A helix-to-coil transition at the  -cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

(2009) T. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

(2008) Jens Radzimanowski et al.   EMBO REPORTS

Prointerleukin-18 Is Activated by Meprin βin Vitroandin Vivoin Intestinal Inflammation

(2008) Sanjita Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease Meprinβ in Rat Kidney: Glomerular Localization and Differential Expression in Glomerulonephritis

(2008) Beatrice Oneda et al.   PLoS One