Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production

Characterization of an Atypical γ-Secretase Complex from Hematopoietic Origin

(2010) Lisa Placanica et al.   BIOCHEMISTRY

 -Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin

(2010) G. Zhao et al.   JOURNAL OF NEUROSCIENCE

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Miniaturized 1536-Well Format γ-Secretase Assay

(2009) Christopher C. Shelton et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity

(2009) Daniel R. Dries et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An exo-cell assay for examining real-time γ-secretase activity and inhibition

(2009) Christopher C Shelton et al.   Molecular Neurodegeneration

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

(2009) Lisa Placanica et al.   PLoS One

Modulation of  -secretase specificity using small molecule allosteric inhibitors

(2009) C. C. Shelton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY