Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

Effect of a Dominant-Negative Form of ADAM10 in a Mouse Model of Alzheimer's Disease

(2017) Anja Schroeder et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

(2009) Qipeng Zhang et al.   ACTA NEUROPATHOLOGICA

Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

(2009) Jennifer C. Palmer et al.   AMERICAN JOURNAL OF PATHOLOGY

Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase†

(2009) Edith Winkler et al.   BIOCHEMISTRY

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain

(2009) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

ADAM9 Is Involved in Pathological Retinal Neovascularization

(2009) V. Guaiquil et al.   MOLECULAR AND CELLULAR BIOLOGY

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

(2009) Ji Zhao et al.   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Alzheimer's dementia by circulation disorders: when trees hide the forest

(2009) Carlos G. Dotti et al.   NATURE CELL BIOLOGY

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential β-secretases

(2008) Livia Böhme et al.   BIOLOGICAL CHEMISTRY

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

(2008) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Isoaspartate residues dramatically influence substrate recognition and turnover by proteases

(2008) Livia Böhme et al.   BIOLOGICAL CHEMISTRY

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promotion of BACE1 mRNA Alternative Splicing Reduces Amyloid β-Peptide Production

(2008) Karen R. Mowrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1

(2008) Vincent Boissonneault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ

(2008) Stephan Schilling et al.   JOURNAL OF NEUROCHEMISTRY

Effects of TNF -Converting Enzyme Inhibition on Amyloid   Production and APP Processing In Vitro and In Vivo

(2008) M. L. Kim et al.   JOURNAL OF NEUROSCIENCE

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of  -Site Amyloid Precursor Protein-Cleaving Enzyme 1

(2008) W.-X. Wang et al.   JOURNAL OF NEUROSCIENCE

First Demonstration of Cerebrospinal Fluid and Plasma A  Lowering with Oral Administration of a  -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

(2008) S. Sankaranarayanan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models

(2008) V. Corsetti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Serum cystatin C and the risk of Alzheimer disease in elderly men

(2008) J. Sundelof et al.   NEUROLOGY

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

(2008) T. Dejaegere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced clearance of A  in brain by sustaining the plasmin proteolysis cascade

(2008) J. S. Jacobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Structure and function of γ-secretase

(2008) Alexandra Tolia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy

(2007) Patrice Delobel et al.   AMERICAN JOURNAL OF PATHOLOGY

MMP-2, -3 and -9 levels and activity are not related to Aβ load in the frontal cortex in Alzheimer's disease

(2007) S. Baig et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY